Guest guest Posted May 4, 2005 Report Share Posted May 4, 2005 how much nicotinamide and how is it working any feedback on this yet? bleu > Re:Message: 9 > - Thanks for the references and Matts original > post. I think I'll email this to Wheldon, who has > kindly responded to other questions in the past, and > see what he says. As a medical microbiologist and MD > treating actual cases (in Cpn) he may have a more > complex take on this. If he replies I'll post it. I'll > also ask his opinion on the " metro wall " phenomenon-- > herx or sensitization, that is the question. > > Wheldon, in my read, is referring to what Stratton > calls the " cryptic " form (Stratton actually referrs to > two cryptic stages, one of which is especially > sensitive to nicotinamide related agents- it took me a > third read of his patent papers to register this) as > the non-replicating phase. > A good puzzle to follow! > Jim > > Date: Tue, 03 May 2005 21:31:44 -0000 > From: " Hodologica " <usenethod@...> > Subject: Jim - metronidazole > > Jim, > > Here are the papers: > > http://www.ub.rug.nl/eldoc/dis/medicine/e.j.van.der.wouden/c8.pdf > > http://tinyurl.com/62tz2 > > And if those dont work, here is Matts earlier post > #92, from which I > got both papers: > > infections/messag > e/92 > > Your idea about the metro-wall could be right, but I > cant really > say. I dont know if the reduced (active) form > circulates - I kinda > suspect not - in the 2nd paper there they found that > non-metro- > reducing cells were unharmed when mixed with metro and > metro- > reducing cells. The reduced form may be so reactive > that it exists > only something very roughly like one second or less, > before being re- > oxidized in a reaction that damages some other > molecule. Also, > enzymes are not depleted or worn out by use; they are > just molecular > machines that basically stay in good shape, re-usably. > Saturation > occurs if there is too much substrate present, > relative to the > number of copies of the enzyme - the enzymes get > " backed up " , at > which point the enzymatic reaction does not stop, but > its rate has > maxed out and substrate may continue to accumulate. > But some enzymes > in the liver (and elsewhere?) are inducible, meaning > the body can > sense their saturation and respond by synthesizing > extra enzyme > copies. All my knowledge is pretty vague since I'm > just taking early > college bio classes now. > > I think I see what you mean about what Wheldon's > saying. By non- > replicating form, do you know if he means the > elementary body, or > something else? > > > > > - > > Quote Link to comment Share on other sites More sharing options...
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