Re: More from Dr. Schardt/nystatin (antifungals- Duramater)

[Guest guest]

Dura:

I think most people on this list realize Nystatin isn't a systemic

drug, and only works in the gut. It's really sonsidered a topical

drug. ... alot of activity goes on in the intestines- and who knows?

It's possible the action of Nystatin in the gut changes the way alot

of other things get absorbed (or not).

Since J brought up Lamisil, and we're talking about

anti-fungals, antibacterials and " Matrial Law " .... maybe some people

didn't realize that NYSTATIN (which is from a soil fungal species)

binds to ERGOSTEROL

and ergosterol is:

QUOTE FROM REFERENCE:

Ergosterol is the biological precursor to Vitamin D2. It is turned

into viosterol by ultraviolet light, and is then converted into

ergocalciferol, which is a form of Vitamin D. END QUOTE

Back before the The members of the 'group that shall remain

nameless' went public, they were using KETOCONAZOLE cream on their

skin extolling it' virtues about the cream inhibiting VIT D

production in the skin.. and if you search on VitD/ketonazole you'll

see their discussion. I think I was the one that actually did the

research for them and explained why the cream worked-

giving them REF. #1)

( I don't read their crap anymore because you can't separate the

wheat from the chaff anymore )...

Antifungals have alot more than one mode of action in the body -

and probably like alot of drugs (as Penny points out) most of them

are not well understood. (see ref # 2)

ALot of the antifungals act on the P450 enzymes-

Ketoconazole inhibits the CYP3A4 P450 enzyme so therefore can

INCREASE the concentration of other drugs (or substances) that use

that particular pathway. Theres always a cause and effect for

tampering with these enzymes - it's not just like turning on or off a

faucet. (see Ref 3)

And I tend to agree with Tony on alot of points- including that

antifungals can proabablt work against bacteria- hell they all

originated in the soil at one time- and had to live together, so it's

not all that far fetched in my mind.

Barb

REF1)

http://www.blackwell-synergy.com/links/doi/10.1034/j.1600-

0625.2000.009002097.x/abs/

REF 2

http://www.nizoral2percent.com/hairloss.php

CYP3A4 Enzyme (of the P450 group):

REF 3

http://jpet.aspetjournals.org/cgi/content/full/292/1/310

> > > Penny you write

> > > " Tony's been saying forever that antifungals (like Nystatin)

> will

> > > actually kill the bacteria as well. He's been ridiculed

> endlessly

> > > for it, and here's this doctor doing the same basic thing.

> > >

> > > Not the same basic thing , many antibiotics both fungal &

> > bacterial are

> > > duel to some extent .....Nysatin is a completely different

class

> > of drug

> > > working against fungi in a completely different way to

> Fluconazole

> > &