OK smarties! Optimal serum levels of Abx for Bb?

[Guest guest]

OK, see if this is a stumper for you research afficianados.

My doc & I are trying to determine the optimal serum levels for

minocycline and azithromycin agains Bb. Anyone seen any papers on

this?

The reason behind my query is that I'm going to try transdermal

versions of these drugs (GI problems aplenty and IV is too brutal

and expensive for me currently) and we know the absorption to be

highly variable. We can probably get serum concentrations measured,

but need a metric against which to assess it.

Thanks for any info or pointers...

PS to Pope isimus: I've been on IV rocephin, claforan,

(developed allergies to these two) vancomycin, and primaxin (moved

to these to complete treatment) at various times (I think my max

time was 12 weeks total). Anyway, I got SO MUCH BETTER on them. I

had remissions from 1.5-5 years after a nice solid treatment

period. Each time I went from bedridden (and twice needing to re-

learn to read and walk after meningitis) to able to work at least

part time. All this to say, I hope you get some relief from your

pending Rocephin treatment.