Guest guest Posted May 1, 2005 Report Share Posted May 1, 2005 I finally got around to looking into the fungal angle some, and really appreciate your web site. I've read several of the papers on the antifungal properties of amiodarone. They are fascinating. This paper: http://tinyurl.com/a8zyb PMID: 12754197 shows impressive synergy of 2 to 4 uM amiodarone when combined with azoles. It says that this is " low, micromolar doses " . That's important because this drug is, frankly, a bit scary. Can have serious side-effects, interactions with antimycotics and antibiotics (and ARBs?) and has a very long half-life. But this paper: http://tinyurl.com/bvkzw PMID: 11752116 says, " The plasma concentration of amiodarone that are used clinically for treatment of arrhythmia can be in the range of 1 to 4 uM during loading periods. " That makes me think that 2 to 4 uM isn't so low. What is your take on this? Have you come across any testimony on the use of amiodarone to potentiate the azoles? Was it successful and were there adverse reactions? Are there any forums out there where people are discussing this? Thanks, Matt Quote Link to comment Share on other sites More sharing options...
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