Re: OK smarties! Optimal serum levels of Abx for Bb?

[Guest guest]

Working on answering my own question here. Are the MIC/MBC values

found in the literature (in vitro) equivalent to the minimum serum

concentration values one would hope to achieve in vivo? Is that the

basic value of determining MIC/MBC values?

> OK, see if this is a stumper for you research afficianados.

>

> My doc & I are trying to determine the optimal serum levels for

> minocycline and azithromycin agains Bb. Anyone seen any papers on

> this?

>

> The reason behind my query is that I'm going to try transdermal

> versions of these drugs (GI problems aplenty and IV is too brutal

> and expensive for me currently) and we know the absorption to be

> highly variable. We can probably get serum concentrations

measured,

> but need a metric against which to assess it.

>

> Thanks for any info or pointers...

>

> PS to Pope isimus: I've been on IV rocephin, claforan,

> (developed allergies to these two) vancomycin, and primaxin (moved

> to these to complete treatment) at various times (I think my max

> time was 12 weeks total). Anyway, I got SO MUCH BETTER on them.

I

> had remissions from 1.5-5 years after a nice solid treatment

> period. Each time I went from bedridden (and twice needing to re-

> learn to read and walk after meningitis) to able to work at least

> part time. All this to say, I hope you get some relief from your

> pending Rocephin treatment.

[Guest guest]

that's what i was thinkin', sort of glad you asked since i don't

feel sure.

> > OK, see if this is a stumper for you research afficianados.

> >

> > My doc & I are trying to determine the optimal serum levels for

> > minocycline and azithromycin agains Bb. Anyone seen any papers

on

> > this?

> >

> > The reason behind my query is that I'm going to try transdermal

> > versions of these drugs (GI problems aplenty and IV is too

brutal

> > and expensive for me currently) and we know the absorption to be

> > highly variable. We can probably get serum concentrations

> measured,

> > but need a metric against which to assess it.

> >

> > Thanks for any info or pointers...

> >

> > PS to Pope isimus: I've been on IV rocephin, claforan,

> > (developed allergies to these two) vancomycin, and primaxin

(moved

> > to these to complete treatment) at various times (I think my max

> > time was 12 weeks total). Anyway, I got SO MUCH BETTER on

them.

> I

> > had remissions from 1.5-5 years after a nice solid treatment

> > period. Each time I went from bedridden (and twice needing to

re-

> > learn to read and walk after meningitis) to able to work at

least

> > part time. All this to say, I hope you get some relief from

your

> > pending Rocephin treatment.

[Guest guest]

No... for example the Bb in vitro MBC for zith is very very low; one

takes lots more than the amount needed to produce that concentration

in serum.

You can find experiments out there that give the peak serum levels for

a given oral dose with/without food in healthy normals, with standard

deviations, etc. IME it takes some long tedious digging on google to

find them for some drugs.

> > OK, see if this is a stumper for you research afficianados.

> >

> > My doc & I are trying to determine the optimal serum levels for

> > minocycline and azithromycin agains Bb. Anyone seen any papers on

> > this?

> >

> > The reason behind my query is that I'm going to try transdermal

> > versions of these drugs (GI problems aplenty and IV is too brutal

> > and expensive for me currently) and we know the absorption to be

> > highly variable. We can probably get serum concentrations

> measured,

> > but need a metric against which to assess it.

> >

> > Thanks for any info or pointers...

> >

> > PS to Pope isimus: I've been on IV rocephin, claforan,

> > (developed allergies to these two) vancomycin, and primaxin (moved

> > to these to complete treatment) at various times (I think my max

> > time was 12 weeks total). Anyway, I got SO MUCH BETTER on them.

> I

> > had remissions from 1.5-5 years after a nice solid treatment

> > period. Each time I went from bedridden (and twice needing to re-

> > learn to read and walk after meningitis) to able to work at least

> > part time. All this to say, I hope you get some relief from your

> > pending Rocephin treatment.

[Guest guest]

Dura:

Everything your DOc will need is in these drug papers.:

Mino:

http://www.blackwell-synergy.com/links/doi/10.1046/j.1365-

2230.1997.1730619.x/abs/

Everything you wanted to know about Zith:

http://www.facm.ucl.ac.be/theses-facm/tyteca/Tyteca-PhD-Thesis-LR.pdf

and

http://www.fda.gov/medwatch/SAFETY/2003/03DEC_PI/Zithromax_PI.pdf

Barb

> OK, see if this is a stumper for you research afficianados.

>

> My doc & I are trying to determine the optimal serum levels for

> minocycline and azithromycin agains Bb. Anyone seen any papers on

> this?

>

> The reason behind my query is that I'm going to try transdermal

> versions of these drugs (GI problems aplenty and IV is too brutal

> and expensive for me currently) and we know the absorption to be

> highly variable. We can probably get serum concentrations

measured,

> but need a metric against which to assess it.

>

> Thanks for any info or pointers...

>

> PS to Pope isimus: I've been on IV rocephin, claforan,

> (developed allergies to these two) vancomycin, and primaxin (moved

> to these to complete treatment) at various times (I think my max

> time was 12 weeks total). Anyway, I got SO MUCH BETTER on them. I

> had remissions from 1.5-5 years after a nice solid treatment

> period. Each time I went from bedridden (and twice needing to re-

> learn to read and walk after meningitis) to able to work at least

> part time. All this to say, I hope you get some relief from your

> pending Rocephin treatment.