Clinical potential of Minocycline for Neurogegerative disorders

[Guest guest]

This is the paper I promised to post (and then didn't).

The full paper is impressive - but I can't find the addy for that

right now.

Barb

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15571972

Neurobiol Dis. 2004 Dec;17(3):359-66. Related Articles, Links

Clinical potential of minocycline for neurodegenerative disorders.

Blum D, Chtarto A, Tenenbaum L, Brotchi J, Levivier M.

Laboratory of Experimental Neurosurgery, ULB-Erasme, 1070 Brussels,

Belgium. .Blum@...

Minocycline, an antibiotic of the tetracycline family, has been shown

to display neurorestorative or neuroprotective properties in various

models of neurodegenerative diseases. In particular, it has been

shown to delay motor alterations, inflammation and apoptosis in

models of Huntington's disease, amyotrophic lateral sclerosis and

Parkinson's disease. Despite controversies about its efficacy, the

relative safety and tolerability of minocycline have led to the

launching of various clinical trials. The present review summarizes

the available data supporting the clinical testing of minocycline for

these neurodegenerative disorders. In addition, we extend our

discussion to the potential applications of minocycline for combining

this treatment with cellular and molecular therapy.

Publication Types:

Review

PMID: 15571972 [PubMed - indexed for MEDLINE]