multiple sclerosis: the new finding in very simple terms

[Guest guest]

As I understand it:

" Adaptive immunity " is the very powerful, focused immune response to

the presence of particular molecules.

" Autoimmunity " is generally understood to refer to activation of this

powerful focused adaptive immunity against SELF molecules - exceptions

below (*)

There just aint no adaptive immunity without local presence of

antibody or T cells, so if something ( " suicide " of myelin-cells) is

happening in early MS lesions before any sort of white cells arrive,

either anti-self antibody is getting things started or else things are

getting started *without* an anti-self reaction by the adaptive immune

system. Which is the big news.

* It also looks possible that sterile inflammation could come from

profound dysregulation of the life cycle of immune cells which cause

there to be too many of them. And there is also the possibility that

apoptotic cleavage or other irregular tranformations of self molecules

and/or abnormalities in their pattern of exposure to the immune system

could lead to autoimmunity against such " semi-self " molecules. The

latter possibility is theoretical as far as I know.

[Guest guest]

man. They just try so hard to prove a flawed immune system, and to

promote auto-immune theories.

B.

>

> As I understand it:

>

> " Adaptive immunity " is the very powerful, focused immune response to

> the presence of particular molecules.

>

> " Autoimmunity " is generally understood to refer to activation of

this

> powerful focused adaptive immunity against SELF molecules -

exceptions

> below (*)

>

> There just aint no adaptive immunity without local presence of

> antibody or T cells, so if something ( " suicide " of myelin-cells) is

> happening in early MS lesions before any sort of white cells arrive,

> either anti-self antibody is getting things started or else things

are

> getting started *without* an anti-self reaction by the adaptive

immune

> system. Which is the big news.

>

>

> * It also looks possible that sterile inflammation could come from

> profound dysregulation of the life cycle of immune cells which cause

> there to be too many of them. And there is also the possibility that

> apoptotic cleavage or other irregular tranformations of self

molecules

> and/or abnormalities in their pattern of exposure to the immune

system

> could lead to autoimmunity against such " semi-self " molecules. The

> latter possibility is theoretical as far as I know.