Minocycline vs Pain Hypersensitivity

[Guest guest]

Oooooh, this little paragraph from the pain article in Science got my

attention:

" Rather than inhibiting signal transduction, DeLeo inhibits microglial

activation with the antibiotic minocycline. Its mechanism is not

entirely clear, but the inhibition is specific to microglia, leaving

astrocytes and neurons unaffected. Not only does minocycline block the

development of pain hypersensitivity, a related suppression of

proinflammatory cytokines is observed.4 "

It's from the first of the links provided by Minoucat:

http://www.the-scientist.com/2005/03/28/S24/1