Re: Is metformin one of the better choices re: in...

[Guest guest]

I am wondering how Dr. Shoemaker's work, more specifically his recommendation that Actos be used to quell a herx, might fit in to this picture. Does anyone have a handle on this?

> If your abx regimen is triggering a herx reaction (inflammation) > then that can increase insulin resistance that can be seen as > elevated blood sugars. Elevated blood sugars will trigger the > inflammatory cascade in a very similar fashion that microbial > pathogens do. So, in the case of diabetes, the body responds as > though it is infected. The reciprocal of that is that an acquired > chronic inflammatory disease (A-CID) will cause insulin resistance > and can lead to diabetes.> >> > It's important to keep inflammation under control while trying to > kill the pathogens triggering it.> > and everyone:Is Glucophage/metformin one of the best or better choices in protecting our body while killing bugs? I know that some insulin resistance is inability to get meaningful exercise, but I am hoping that the metformin will help to keep some of the insulin peaks contributing to inflammation down while we are killing pathogens.I know that there are lots of diabetes meds. My main interest is learning which of these are best for us patients with lyme, mycoplasma, and other chronic infections not necessarily for diabetes.thank youTonkinese>

[Guest guest]

IMO, pioglitazone (Actos) would be a better choice than metformin

(Glucophage).

Actos is a potent and highly selective agonist for peroxisome

proliferator-activated receptor-gamma (PPARg). PPARg receptors are

found in tissues important for insulin action such as adipose

tissue, skeletal muscle, and liver. Activation of PPARg nuclear

receptors modulates the transcription of a number of insulin

responsive genes involved in the control of glucose and lipid

metabolism. PPARg are also significantly involved in the

inflammatory cascade. Actos is know to inhibit TNF-alpha.

There are several things you can do to help normalize blood sugars

and reduce inflammation...

> I am wondering how Dr. Shoemaker's work, more specifically his

recommendation

> that Actos be used to quell a herx, might fit in to this picture.

Does anyone

> have a handle on this?

>

>

>

> > If your abx regimen is triggering a herx reaction (inflammation)

> > then that can increase insulin resistance that can be seen as

> > elevated blood sugars. Elevated blood sugars will trigger the

> > inflammatory cascade in a very similar fashion that microbial

> > pathogens do. So, in the case of diabetes, the body responds as

> > though it is infected. The reciprocal of that is that an

acquired

> > chronic inflammatory disease (A-CID) will cause insulin

resistance

> > and can lead to diabetes.

> > >>

> > It's important to keep inflammation under control while trying

to

> > kill the pathogens triggering it.

> >

> >

>

> and everyone:

>

> Is Glucophage/metformin one of the best or better choices in

> protecting our body while killing bugs? I know that some insulin

> resistance is inability to get meaningful exercise, but I am

hoping

> that the metformin will help to keep some of the insulin peaks

> contributing to inflammation down while we are killing pathogens.

>

> I know that there are lots of diabetes meds. My main interest is

> learning which of these are best for us patients with lyme,

> mycoplasma, and other chronic infections not necessarily for

> diabetes.

>

> thank you

>

> Tonkinese

> >