Guest guest Posted April 18, 2005 Report Share Posted April 18, 2005 <jenbooks13@h...> wrote: > Has anyone thought about the fact that metrodinAZOLE and tinidAZOLE > work in lyme, and this is fluconAZOLE? They may be different and yet > they are all azoles. Would be a good point, but are you sure? I have no idea whether they bear chemical relation. To my knowledge, which is limited, they bear no relation in biochemical action. Antifungal triazoles inhibit CYP 450 enzymes and block fungal ergosterol synth; nitromidazoles (flagyl, tini), i understand, are metabolized into DNA-damaging species. That may not be the *whole* story tho - chemicals dont necessarily have just one action; they do exactly whatever nature may bid them to do, and there could easily be a well-known relation I'm unaware of. I do know tini has some anti-fungal power according to the Brorson group. Quote Link to comment Share on other sites More sharing options...
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