Re: Alzheimer's Gene - Crohns gene

[Guest guest]

Interesting. Theres this allele in Crohn's disease (see ~100 papers

in pubmed) where your NOD-2 protein is messed up. NOD-2 is a

bacterial pattern recognition receptor, like the TLR family, and it

is intracellular. Very roughly, the frequency of the mutated alleles

is something like 25% in Crohn's and 1% in healthies, so its not the

" cause " of Crohns, but a serious contributer. Its frequency is

normal in ulcerative colitis, which is restricted to the large bowel

and is non-granulomatous I think.

The precise nature of the mutation is, if I recall, a single

nucleotide deletion resulting in frameshift - these usually result

in a termination codon being read not far downstream, so basically a

big chunk is missing off the end of the protein and it doesnt do its

thing well or at all.

>

> I read both papers, and this gene seems to

> heighten the inflammatory response.

>

> So .. the way I interpret it, it's just another

> genetic variant in the host about how a disease will present.

>

> I can connect the dots and say.. if the gene is present, and you

> have untreated un diagnosed Lyme for 30 years, you may develope

> symptoms that end up being diagnosed as Alzheimers.

>

> Remember Alzheimners is just another 'syndrom' becuase they

> do not know the cause.

>

> Barb