Re: HCQ/Macrolide/Brorsons/Donta - Nelly

March 22, 2005

True.

Dontas experiment has a control: he says HCQ does not add anything

to tetracycline therapy. But he doesnt give the data.

Nelly reports having heard Donta only takes " classic " cases in which

there isnt cause to suspect co-infections - any more info on that,

Nelly? I wonder if that may apply to his studies, which apparently

were done in his clinic, but dont mention those inclusion criteria?

An interesting question is whether HCQ action on cysts shows O2

dependance as tini does:

And whether those O2 dependances are relevant over physiological

concentrations....

And whether one of the two is superiorly active at achievable

doses...

And which can traverse BBB better...

I think I want to take one of these drugs soon so I'll be shakin

these questions.

Its interesting to consider Donta theory in light of the lyme TEM.

Almost all TEM authors agree that very few borrelia can be found. I

cannot speak to the true nitty gritty of whether reliance on

techniques like needle biopsy, etc, may limit success in finding the

organism. But - if there IS a " missing biomass " , and it were inside

a vacuole, in whatever form, it should be alot easier to see, as far

as I know, than if it were free in cytoplasm. What I'm driving at is

that if there are in fact alot of borrelia present in lyme, and they

were largely envacuolated, I would sorta expect them to have been

discovered, but I definitely cant say I understand everything that

might be relevant to making that judgement.

I do know, firmly, that small variants in cytoplasm can be virtually

impossible to positively identify visually even with excellent TEM.

Im talkin about the Wirostko/ uveitis L-forms here. You

cannot confidently pick them out of a lineup of innocent eucaryote

organelles like mitochondria and leukocyte granules. Its the

occasional associated severe cytopathy and walled forms - but even

moreso the excellent supporting experiments executed by that group -

that showed what they had were bacteria for certain. I have the

impression that a TEM observer lacking certain knowledge could have

totally missed what that group found.

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