Re: Re: Minocycline vs Pain Hypersensitivity - Kate &

[Guest guest]

Yes, good to look at all the possibilities, although most people go on

the Benicar first, and many have gotten some relief before starting the

mino.

- Kate

On Sunday, April 10, 2005, at 07:26 PM, duramater27 wrote:

>

> Of course, another plausible alternative hypothesis is that its the

> minocycline acting as the anti-inflammatory and the benicar isn't

> doing bupkis.  [i have no experience or assessment of mino/benicar

> combo, just stating a plausible hypothesis]

[Guest guest]

0 l00ks like y0u have the hiccups...l0l

>

> Of course, another plausible alternative hypothesis is that its the

> minocycline acting as the anti-inflammatory and the benicar isn't

> doing bupkis.  [i have no experience or assessment of mino/benicar

> combo, just stating a plausible hypothesis]

>

> The link for the original article (full text) on minocycline/pain is:

> http://jpet.aspetjournals.org/cgi/content/full/306/2/624

>

> Take a gander at tables 3 & 4 in particular looking at reduction of

> IL-1 & TNF-a with mino.  Now, of note, the dosages used in rats

> aren't something I'd be using (40 mg/kg! hey,that would be 1880 mgs

> a day for me, no thank you!) so I don't know what the implications

> are for humans, so....

>

> In addition, if 0ne d0es a search 0n min0cycline (s0rry, have t0

> use " zer0 " as an 0 as my 0 key seems t0 have died suddenly!) and

> anti-inflammat0ry, y0u see s0me interesting uses/investigati0ns 0f

> min0 in dementia, ALS, str0ke, etc b/c 0f neur0immune m0dulating

> pr0perties, etc.  At least 0ne study l00ks at n0n-antibi0tic

> anal0gues t0 be sure it is an anti-inflammat0ry resp0nse and n0t an

> antibi0tic 0ne...

>

>

> > >

> > > > " Not only does minocycline block the

> > > > development of pain hypersensitivity, a related suppression of

> > > > proinflammatory cytokines is observed.4 "

> > > >

> > > > It's from the first of the links provided by Minoucat:

> > > >

> > > > http://www.the-scientist.com/2005/03/28/S24/1

>

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