Re: Minocycline - Barb, Dura Mater

[Guest guest]

I wonder if all these effects procede from the " mitoribosome "

(mitochondrial ribososme) inhibition brought up by Matt. Dura Mater

mentioned that some non-antibacterial cyclines are also

anti-inflammatory; I once saw a similar finding on the web somewhere.

I wonder whether those drugs are able to bind the human mitoribosome.

Personally, I didnt find the anti-inflammatory effect to be all that

large, perhaps comparable to a couple advils or less, but I did

experience it immediately when I first started doxy 100 mg tid. I felt

a little crack in my anhedonia and body malaise, which stuck out cause

I never took advil or the like in those days.

<egroups1bp@y...> wrote:

>

> That's a possibility.

> At low dose it could work like a low dose NSAID (as a pain releiver)

> especially on the microglia, which product cytokines.

> I have a very good paper somewhere that lists all of Mino's non-

> microbial mechanisms. Anti-microbial effects aside - Mino's pretty

> impressive as far as it's supressive qualities go.

> Barb

[Guest guest]

Mino has excellent anti-microbial qualities at therapeutic doses,

especially for intracellular patogens, and it penetrates the brain 10

times better than DOxy..

It also has many supressive qulities that have been exstensively

studied.. so those qualities cannot be dismissed.

My suspicians are that if symptoms come back a few days after

stopping Mino.. then it's been acting as a pain releiver.

I'll find that paper I talked about earlier and post it.

It lists an impressive array of (supressive) mechanisms for Mino

Barb

> >

> > That's a possibility.

> > At low dose it could work like a low dose NSAID (as a pain

releiver)

> > especially on the microglia, which product cytokines.

> > I have a very good paper somewhere that lists all of Mino's non-

> > microbial mechanisms. Anti-microbial effects aside - Mino's

pretty

> > impressive as far as it's supressive qualities go.

> > Barb

[Guest guest]

Barb,

What, in your opinion, can be made of incredibly INCREASED inflammation (especially head and eyes) when on minocycline?

I never experienced any reduction in pain, do you think this might indicate that my eye/head/brain pain might not be inflammatory in nature (sure feels like it is)?

Initially when I first took doxy I experienced a brief (a couple of days) feeling of things coming untight then massive inflammation (absolutely unbearable).

I now can take 200 or 300 mg of doxy without the punishment ("herx?") but still have this major inflammation with minocycline (even every other day), even small doses (never went into the low-low doses, min 100 mg EOD).

I am at present combining an older macrolide (spiramycine) + doxy 200 mg cycling in tini 1g for 5-6 days every 3 weeks (more or less Wheldon's protocol). Seeing some improvements especially in sleep patterns which appear to have improved (I sleep earlier, with less sleeping aids and better), it made me very tired early on (been on it for about 6 weeks about to go on my second cycle of tini, as you know I have used tini before but second time as a part of the Wheldon protocol). I was thinking of substituting mino 100mg for the doxy 200 mg used in the protocol for better brain penetration but balking at the probable unbelievable, unbearable and worrying brain pain that it will probably trigger.

BTW I have stopped the lariam (after having been on it for about 2 years!) and I have resumed taking artemisinin (Allergy research 200 mg BID, with grapefruit juice). I seem to be tolerating it a lot better than when I first tried it 2 years ago, when it caused my brain to overheat so much you could've cooked an egg on top of my head and spinal area, the atovaquone and the lariam both caused exactly the same symptoms/herx.

BBTTWW, Bleu (and others interested) I am seeing my ID doctor next friday and I am reviewing my diary in preparation for the consultation: I took 2 weeks of pristinamycine 2g with tini 1g for 2 weeks (before I started on the Wheldon regimen) and the first week was honeymoonish, I was able to do things outside every day culminating in a visit to an endocrinologist followed by a whole afternoon at ....IKEA of all places! (can anyone think of a heavier afternoon of activity?) The next day I nearly died of one of THEM headaches! Continued the tini + pristinamycin for another week but had to give up due to persisting headache.

Nelly

[infections] Re: Minocycline - Barb, Dura Mater

Mino has excellent anti-microbial qualities at therapeutic doses, especially for intracellular patogens, and it penetrates the brain 10 times better than DOxy.. It also has many supressive qulities that have been exstensively studied.. so those qualities cannot be dismissed. My suspicians are that if symptoms come back a few days after stopping Mino.. then it's been acting as a pain releiver.I'll find that paper I talked about earlier and post it.It lists an impressive array of (supressive) mechanisms for MinoBarb

[Guest guest]

Hi Nelly:

To your question about the increase in head/eye symptoms

while on Mino and my paradoxically statement

about Mino having anti-imflammatory properties:

Yes .. I know it sounds like a contradiction - but think of it as

Mino causing a " localized' herx, but the additional properties of

Mino supress some of the release of certain chemicals that would

actually make the localized inflammation much worse than what's

experienced.

IMO,

I would not of been able to handle Mino if I hadn't taken a ton of

DOxy (and other abx) first. Mino has 10 X the tissue penetration

Doxy. 10 X- that's alot... and I know most of my Lymecolonies were in

tissue - probably lining my brain, etc..since almost all my pain was

neuro.

I did have have problems with my eyes when I first introduced Mino..

(that's why I pulsed) but I don't have the problem now when I take

Mino.

Barb

PS-

I'll post that paper tomorrow.

> Barb,

>

> What, in your opinion, can be made of incredibly INCREASED

inflammation (especially head and eyes) when on minocycline?

>

> I never experienced any reduction in pain, do you think this might

indicate that my eye/head/brain pain might not be inflammatory in

nature (sure feels like it is)?

>

> Initially when I first took doxy I experienced a brief (a couple of

days) feeling of things coming untight then massive inflammation

(absolutely unbearable).

>

> I now can take 200 or 300 mg of doxy without the punishment

( " herx? " ) but still have this major inflammation with minocycline

(even every other day), even small doses (never went into the low-low

doses, min 100 mg EOD).

>

> I am at present combining an older macrolide (spiramycine) + doxy

200 mg cycling in tini 1g for 5-6 days every 3 weeks (more or less

Wheldon's protocol). Seeing some improvements especially in sleep

patterns which appear to have improved (I sleep earlier, with less

sleeping aids and better), it made me very tired early on (been on it

for about 6 weeks about to go on my second cycle of tini, as you know

I have used tini before but second time as a part of the Wheldon

protocol). I was thinking of substituting mino 100mg for the doxy 200

mg used in the protocol for better brain penetration but balking at

the probable unbelievable, unbearable and worrying brain pain that it

will probably trigger.

>

> BTW I have stopped the lariam (after having been on it for about 2

years!) and I have resumed taking artemisinin (Allergy research 200

mg BID, with grapefruit juice). I seem to be tolerating it a lot

better than when I first tried it 2 years ago, when it caused my

brain to overheat so much you could've cooked an egg on top of my

head and spinal area, the atovaquone and the lariam both caused

exactly the same symptoms/herx.

>

>

> BBTTWW, Bleu (and others interested) I am seeing my ID doctor next

friday and I am reviewing my diary in preparation for the

consultation: I took 2 weeks of pristinamycine 2g with tini 1g for 2

weeks (before I started on the Wheldon regimen) and the first week

was honeymoonish, I was able to do things outside every day

culminating in a visit to an endocrinologist followed by a whole

afternoon at ....IKEA of all places! (can anyone think of a heavier

afternoon of activity?) The next day I nearly died of one of THEM

headaches! Continued the tini + pristinamycin for another week but

had to give up due to persisting headache.

>

> Nelly

> [infections] Re: Minocycline - Barb, Dura

Mater

>

>

>

>

> Mino has excellent anti-microbial qualities at therapeutic doses,

> especially for intracellular patogens, and it penetrates the

brain 10

> times better than DOxy..

> It also has many supressive qulities that have been

exstensively

> studied.. so those qualities cannot be dismissed.

>

> My suspicians are that if symptoms come back a few days after

> stopping Mino.. then it's been acting as a pain releiver.

>

> I'll find that paper I talked about earlier and post it.

> It lists an impressive array of (supressive) mechanisms for Mino

>

> Barb