Nelly- HCQ/Mino

[Guest guest]

Nelly:

Yes, I've read that paper on HCQ/Doxy (and Donta's stuff on

HCQ/Tetracycline)... and as you know I've combined HCQ with alot of

abx based on Donta's original theory (and I think I have had

excellent abx response).

Maybe I'm just more sensitive to HCQ/Mino combo than HCQ/Doxy...

I just wondered if anyone else had to reduce the dosages of HCQ/Mino

(other than me that is).

Barb

____________________________________________________________

Barb,

I am quite sure you have read this already and it is not using mino +

HCQ but doxy +HCQ

" CONCLUSION: Prescription of the doxycycline and hydroxychloroquine

combination for at least 18 months allows shortening of the duration

of therapy and reduction in the number of relapses. "

Nelly

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=9927100

Arch Intern Med. 1999 Jan 25;159(2):167-73.

Treatment of Q fever endocarditis: comparison of 2 regimens

containing doxycycline and ofloxacin or hydroxychloroquine.

Raoult D, Houpikian P, Tissot Dupont H, Riss JM, Arditi-Djiane J,

Brouqui P.

Unite des Rickettsies, Faculte de Medecine, Universite de la

Mediterranee CNRS, Marseille, France. Didier.Raoult@...-

mrs.fr

BACKGROUND: Q fever endocarditis, caused by iella burnetii, is

fatal in 25% to 60% of patients. Currently, treatment with a long-

term tetracycline and quinolone regimen for at least 4 years is

recommended, although relapses are frequent. METHODS: Between January

1987 and December 1997, the reference treatment of Q fever

endocarditis was compared with one of doxycycline and

hydroxychloroquine sulfate. Patients were treated by conventional

therapy until May 1991 and then by the new regimen.

Microimmunofluorescence was used for antibody-level determination for

diagnosis and follow-up. RESULTS: Thirty-five patients were included

in the study, 26 males and 9 females. Of 14 patients treated with a

doxycycline and quinolone combination, 1 died, 7 relapsed (3 were re-

treated and 4 switched to the new regimen), 1 is still being treated,

and 5 were considered cured using this regimen only. The mean

duration of therapy for cure in this group was 55 months (median, 60

months). Twenty-one patients received the doxycycline and

hydroxychloroquine regimen: 1 patient died of a surgical

complication, 2 are still being treated, 17 were cured, and 1 is

currently being evaluated. Two patients treated for 12 months but

none of the patients treated for longer than 18 months relapsed. The

mean duration of treatment in this group was 31 months (median, 26

months). No significant differences were observed between the 2

regimens in terms of death, valve surgery, or tolerance. The

mortality rate for both regimens in this study was 5%. CONCLUSION:

Prescription of the doxycycline and hydroxychloroquine combination

for at least 18 months allows shortening of the duration of therapy

and reduction in the number of relapses.

PMID: 9927100 [PubMed - indexed for MEDLINE]