Re: Re: high homocysteine = low glutathione

[Guest guest]

Fascinating.

What is the connection to sleep and how to fix it. Why do people with

high homocysteine, not sleep at all, and what's the cure?

Bleu

>

> Hi, Colorbleu.

>

> Yes, this is correct.  The methionine (or methylation) cycle is

> coupled to the transsulfuration pathway.  Homocysteine (in the

> methionine cycle) can either be converted back to methionine,

> closing the cycle, by means of vitamin B12 together with folic acid

> or by means of trimethylglycine (betaine), or it can be converted to

> cysteine (in the transsulfuration pathway), by means of vitamin B6,

> and from there can either go into making glutathione or can proceed

> to taurine or to sulfate.  The sulfur in the original homocysteine

> is excreted from the body either as taurine or as sulfate.  The

> amounts that go in each direction are controlled by various

> parameters.  In people who have a genetic defect involving MTHFR,

> the pathway from homocysteine to methionine is inhibited.  In people

> who have mercury toxicity, both the methionine cycle and the pathway

> to glutathione can be inhibited.  Some people also have the pathway

> to sulfate inhibited at the enzyme sulfite oxidase, sometimes

> because of a molybdenum deficiency.  This causes them to be

> sensitive to essentially all foods or supplements containing sulfur,

> because sulfite builds up and produces symptoms.

>

> Rich

>

>

> > Rich Please respond to this statement:

> >

> > The second pathway to lower homocysteine involves converting it

> into

> > cysteine (an very important amino acid), which then through a

> cascade

> > of chemistry becomes glutathione.

> >

> >

> > http://www.y2khealthanddetox.com/truthchol.html

>

>

>

>

>

>

>

[Guest guest]

In people who have a genetic defect involving MTHFR, the pathway from homocysteine to methionine is inhibited. In people who have mercury toxicity, both the methionine cycle and the pathway to glutathione can be inhibited. Some people also have the pathway to sulfate inhibited at the enzyme sulfite oxidase, sometimes because of a molybdenum deficiency. This causes them to be sensitive to essentially all foods or supplements containing sulfur, because sulfite builds up and produces symptoms.

Rich,

How can we determine whether we have these genetic defects?

Nelly

[Guest guest]

would the treatment still be b12, folic acid, and b6?

>

> Nelly,

>

> I think there must be quite a few labs characterizing the MTHFR

> genetic polymorphisms now, because it is turning out to be important

> in several disorders.  One of them in the U.S. is the Great Smokies

> Diagnostic Lab, as part of their Genovations testing.  Check

> http://www.gsdl.com

>

> Another lab in the U.S. is the ARUP lab in Salt Lake City, Utah. 

> The url is http://www.aruplab.com/guides/ug/tests/0055655.jsp

>

> There must be a lab in Paris that does these characterizations as

> well.

>

> Rich

>

>

> >  In people who have a genetic defect involving MTHFR,

> > the pathway from homocysteine to methionine is inhibited.  In

> people

> > who have mercury toxicity, both the methionine cycle and the

> pathway

> > to glutathione can be inhibited.  Some people also have the

> pathway

> > to sulfate inhibited at the enzyme sulfite oxidase, sometimes

> > because of a molybdenum deficiency.  This causes them to be

> > sensitive to essentially all foods or supplements containing

> sulfur,

> > because sulfite builds up and produces symptoms.

> >

> > Rich,

> >

> > How can we determine whether we have these genetic defects?

> >

> > Nelly

>

>

>

>

>

>

>

[Guest guest]

Thanks Rich, I might look into it later when I feel a bit better (eyes so sore I can't stay in front of the screen) but in France molecular tests are almost impossible to get, so I'm almost sure it's not something I would get easily.

Nelly

[infections] Re: high homocysteine = low glutathione

Nelly,I think there must be quite a few labs characterizing the MTHFR genetic polymorphisms now, because it is turning out to be important in several disorders. One of them in the U.S. is the Great Smokies Diagnostic Lab, as part of their Genovations testing. Check http://www.gsdl.comAnother lab in the U.S. is the ARUP lab in Salt Lake City, Utah. The url is http://www.aruplab.com/guides/ug/tests/0055655.jspThere must be a lab in Paris that does these characterizations as well.Rich > In people who have a genetic defect involving MTHFR, > the pathway from homocysteine to methionine is inhibited. In people > who have mercury toxicity, both the methionine cycle and the pathway > to glutathione can be inhibited. Some people also have the pathway > to sulfate inhibited at the enzyme sulfite oxidase, sometimes > because of a molybdenum deficiency. This causes them to be > sensitive to essentially all foods or supplements containing sulfur, > because sulfite builds up and produces symptoms.> > Rich,> > How can we determine whether we have these genetic defects? > > Nelly