Guest guest Posted March 23, 2005 Report Share Posted March 23, 2005 That's very helpful information, Barb. You set kind of a standard for honest presentation of pros and cons. A breath of fresh air, these days. > > Chloroquine (CQ) and hydroxychloroquine (HCQ) are a members of the > quinolone family, at the molecular level, these are different than > fluroquinolines (with which they are sometimes confused). > > There is a molecular distinction between fluroquinoline and > quinolones (please notice the spellings.. the " i " instead of the " o " > and the fluro prefix) which includes their side effects and there are > also distinctions between CQ and HCQ. As far as I know, the tendon > degradation problems with the fluroquinolines are not listed as side > effects by the drug companies witht these anti malarial quinolones. > > But these (antimalarial) drugs do have side efects , especially with > raising the intraocular pressure (and you can't feel that happening). > Chloroquine (CQ) is more dangerous than hydroxychloroquine (HCQ) and > they > have very long half lives, and unbeleivably long wash-out periods > see this site: > http://www.fqresearch.org/vision_archives.htm > > In some infections HCQ is used in combo with other drugs long term > and there's quite a bit of data out there about HCQ and Doxy: > http://archinte.ama-assn.org/cgi/content/abstract/159/2/167 > > My docs baselined my IOC (introcular pressure) when starting HCQ, > even though it used as a monotherapy and used at the safe dose > (<400mg/day) and I was monitored thru higher doses. > > My eyes were really bad, and I was seeing my ohpthalmologist every > week anyway.. measuring a bunch of eye problems - so I was monitored > extremely closely. So although I used > 400mg and in combo with > other abx, for some unknown reason, my intra-ocular pressure never > increased.. So I was lucky. > > And IMO this isn't a drug anyone should self medicate (not that any > one would do that - but I need to say that because we are talking > about ones eyes after all). > > And in my case, there did appear to be a synergy, or additive effect > when HCQ was combined some other abx. (see my other posts on HCQ). > With HCQ and Mino the dosages of both drugs were reduced by about > two thirds or I would reach too high a consentration in the inner > ear, and vestibular dyfunction resulted (disabling vertigo from the > Mino consentration in the inner ear). > > So people - HCQ is a drug that IMO if you use it with other drugs, > you need to be under the care of not just any Dr.. but a smart Dr. > .. you know.. some of these drug combo's are really a double edged > swords, and one really has to weight the risks. > > I really really really worry about the the side efects of toxicity > being misinterpreted as herx when HCQ is used in combo with other abx > because tissue consentration levels will vary greatly between people > depending the combo drug used and the person's own genetic metabolic > make up. > .. and I've seen plenty of reports of people calling these effects > herxes....and I just chringe. > > Barb Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2005 Report Share Posted March 23, 2005 On Tuesday, March 22, 2005, at 08:42 PM, Barb Peck wrote: > As far as I know, the tendon > degradation problems with the fluroquinolines are not listed as side > effects by the drug companies with these anti malarial quinolones. I haven't seen them listed either. > So people - HCQ is a drug that IMO if you use it with other drugs, > you need to be under the care of not just any Dr.. but a smart Dr. That's what I had concluded and since we are still looking for a smart local doctor, I tend to worry. (My son is seeing Dr. J in CT but that's out of the country for us.) > .. and I've seen plenty of reports of people calling these effects > herxes....and I just chringe. Yes, it's torture for me seeing my son take it and not being able to feel the effects myself and make a judgment. For instance, when he gets a stomach ache, I don't know whether it's the HCQ, the Zith, or a herx (he did have digestive system problems before treatment). So far no worse symptoms though. Just muscle aches and so forth. We did take my son for a pre-HCQ eye exam, but they claim he only needs another exam after 6 months. I'm sure we could pay for another one though, to allay our fears. - Kate Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2005 Report Share Posted March 23, 2005 >There is a molecular distinction between fluroquinoline and >quinolones (please notice the spellings.. the "i" instead of the "o" >and the fluro prefix) which includes their side effects and there are >also distinctions between CQ and HCQ. Barb, If you are talking of abx like ciprofloxacin etc I am pretty sure they are "fluroquinolones". In fact, I have never seen "fluroquinolines" mentioned any place. But I agree with you HCQ doesn't carry the same risks of tendon damage as fluroquinolones sometimes carry Nelly Quote Link to comment Share on other sites More sharing options...
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