Guest guest Posted March 7, 2005 Report Share Posted March 7, 2005 Hi Penny and all, I don't know why I obsess over this, but I always want to look up EVERY single ingredient in a product to make sure it's safe, and not toxic (like the Cipro I almost took). It bothered me that the SinoFresh site didn't list the ingredients anywhere on their webpages, but I managed to track 'em down. (I need to get a life!) The end result -- well maybe they're considered dangerous by some, but some are actually used by so-called " reputable " companies like Tom's of Maine. The second ingredient: Benzalkonium chloride was shown to inflame nasal tissues (a rebound effect) in a couple studies, but those studies also contained another ingredient, and in a review of BC, they said the level of inflammation was barely significant. from pubmed: Otolaryngol Head Neck Surg. 2004 Jan;130(1):131-41. Related Articles, Links Safety review of benzalkonium chloride used as a preservative in intranasal solutions: an overview of conflicting data and opinions. Marple B, Roland P, Benninger M. Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, 75390, USA. bradley.marple@... BACKGROUND: For most multiuse aqueous nasal, ophthalmic, and otic products, benzalkonium chloride (BKC) is the preservative of choice. The American College of Toxicology has concluded that BKC can be safely used as an antimicrobial agent at concentrations up to 0.1%. BKC has been in clinical use since 1935 and is contained in a wide variety of prescription and over-the-counter products. However, over the past several years there have been conflicting reports of damage to human nasal epithelia and/or exacerbation of rhinitis medicamentosa associated with intranasal products containing BKC. OBJECTIVE: We sought to review the published literature and determine whether there is sufficient, clinically significant data that would confirm that intranasal products containing BKC are likely to damage human nasal epithelia or exacerbate rhinitis medicamentosa. METHODS: A literature search was conducted for in vivo and in vitro studies that evaluated the effects of BKC on human nasal epithelia. RESULTS: A total of 18 studies (14 in vivo, 4 in vitro) were identified that evaluated short- and long-term exposure of concentrations of BKC in concentrations ranging from 0.00045% to 0.1%. Eight studies, including a 6-month and 1-year long-term treatment study, demonstrated no toxic effects associated with BKC, indicating that BKC was neither harmful to nasal tissue nor prone to exacerbate rhinitis medicamentosa. Furthermore, of the 10 studies that concluded that BKC resulted in degenerative changes in human nasal epithelia (eg, ciliary beat frequency, ciliary morphology, mucociliary clearance, epithelial thinning and/or destruction) or that BKC exacerbates rhinitis medicamentosa, only 2 (it was 2 according to the Results section) of these studies were supported by statistically significant differences between BKC and placebo or active control groups were compared. It is important to note that in both of these studies, the protocol incorporated the use or oxymetazoline in some or all of the subjects. Oxymetazoline is associated with rhinitis medicamentosa. CONCLUSION: Intranasal products containing the preservative BKC appear to be safe and well tolerated for both long- and short-term clinical use. The other questionable ingredients -- polysorbate 80, and propylene glycol are like I said used by Tom's of Maine, and other reputable companies -- SO -- despite my paranoia, I look forward to hearing about Penny's experiences with SinoFresh! And meanwhile, I'll try some mild colloidal silver spray -- just arrived in the mail -- ANOTHER controversial " medicine " . Best regards, Dan > > > Hey everyone, > > I've been having an incredibly annoying salty taste in my mouth that > I can't get rid of (along with a big increase in plaque production). > Through research, I find the number one cause of this is staph > aureus (which I've already tested positive for in my bone > infection). > > Anyway, a friend I trust told me about the following product, Sino > Fresh, which she claims works better than any prescription > antimicrobial spray she's used. I've researched it a bit and the > main ingredient, cetylpyridinium chloride is definitely effective > against bacteria, used in cattle, vegetables, etc. as an > antimicrobial. Anyway, here's a list of the bugs and molds it kills > (some heavy hitters like stachybotrus and MRSA staph A.), along with > some reviews. > > http://www.natlallergy.com/images/SinoFresh.pdf > > http://www.epinions.com/pr-Over-the-Counter_Medicine- > SinoFresh_Moisturizing_Nasal_Sinus_Spray/display_~reviews > > I bought some and am giving it a go. I believe that many of our > fatigue symptoms are caused by these infections festering in our > sinuses, draining into our guts, and recirculating through our blood > stream, so might be worth looking into. > > penny Quote Link to comment Share on other sites More sharing options...
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