Re: Sarc and CFS - serum ACE

[Guest guest]

That is interesting, but I'd sorta expect it to be higher in all the

inflammatory diseases. But I just checked that idea out and found

some odd results - these guys found serum ACE to be LOW in both

crohn's and ulcerative colitis:

11569699

On the other hand these guys - who unlike the other group dont seem

to have controled for genotype - say normal levels for crohn's and

hi for UC:

8381313

Weird. Dono what to make of it.

Cant find anything for lyme or RA right off, and gotta go to class.

> >

> > Hi all

> >

> > you've probably seen this before but I hadn't

> >

> > http://www.ncbi.nih.gov/entrez/query.fcgi?CMD=Mail & DB=pubmed

> >

> > anyone tempted to believe that we might have more in common with

> the

> > sarcs than we thought?

> >

> > Janet

>

> sorry, the index number is 8213873

[Guest guest]

> That is interesting, but I'd sorta expect it to be higher in all the

> inflammatory diseases.

ACE is produced in tissues that have renin-angiotensin systems (RAS).

In some cases, the RAS is local, though, and ACE doesn't enter into

the serum. I.e., in RA, it can be found in the synovial fluid of joints.

Crohn's disease can cause inflammation in various tissues, but mainly

in the small intestine. Apparently the intestine can produce some

ACE, but it's not as much as in other tissues. But the main reason

for normal or low ACE in Crohn's, is likely due to the very high

levels of TNF-alpha. Serum TNF-alpha in Crohn's appears to be much

higher than any other inflammatory condition that I could find. This

could be significant, because TNF-alpha is known to downregulate the

production of ACE:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=12160518

Serum ACE may be depressed because of this effect. However, locally

generated ACE may still be elevated, especially in the intestines,

where there are a different types of macrophages.

Mark