intracell. action: no rhyme or reason even *within* drug classes

[Guest guest]

" Some quinolones had poor activity against M. avium in the monocyte

culture system despite low MICs (< or = 0.25 mg/L); in contrast,

some quinolones with MICs > 32 mg/L showed some inhibition of M.

avium growth within monocytes at 4 mg/L. "

The MIC is the minimum inhibitory concentration, measured using

bacteria floating free in broth (and directly exposed to the drug).

32/4 = 8

PMID: 9182106

[Guest guest]

yeah, that's why it's ludicrous to think that the same drug or the

same dosage (especially low dosage) will work for all people across

the board. There's some kind of individual bacteria/host interaction

going on that makes us all react differently to treatment.

penny

>

> " Some quinolones had poor activity against M. avium in the

monocyte

> culture system despite low MICs (< or = 0.25 mg/L); in contrast,

> some quinolones with MICs > 32 mg/L showed some inhibition of M.

> avium growth within monocytes at 4 mg/L. "

>

> The MIC is the minimum inhibitory concentration, measured using

> bacteria floating free in broth (and directly exposed to the

drug).

>

> 32/4 = 8

>

> PMID: 9182106