Re: Helicobacter pylori and autism?

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The PubMed search

pylori AND (reflux OR diarrhea OR IBS OR IBD OR colitis)

today generated 1450+ citations, many of which appear to offer insights.

The highly restricted search

pylori[ti] AND (reflux[ti] OR diarrhea[ti] OR IBS[ti] OR IBD[ti] OR

colitis[ti] OR irritable[ti])

generated 250+ citations, eg,

0: Neth J Med. 2004 Jun;62(6):188-91.

Helicobacter pylori and gastro-oesophageal reflux disease: a cross-sectional

epidemiological study.

Loffeld RJ, van der Putten AB.

Department of Internal Medicine, de Heel Zaans Medical Centre, PO Box 210, 1500

EE Zaandam, the Netherlands. r.loffeld@...

BACKGROUND: H. pylori infection is accompanied by a lower prevalence of reflux

disease. There is still an ongoing debate as to whether H. pylori actually

protects against the development of reflux oesophagitis or is merely an

epiphenomenon. A cross-sectional study was performed to study the relation of H.

pylori with reflux oesophagitis, hiatus hernia and Barrett's oesophagus.

MATERIAL AND METHODS: Consecutive patients undergoing upper gastrointestinal

endoscopy in a period of ten years were studied. Included were patients with

active reflux oesophagitis and/or hiatus hernia and/or Barrett's oesophagus. As

a reference group, patients without macroscopic abnormalities were included. H.

pylori was detected applying routine diagnostic modalities. RESULTS: In the ten

years 11,691 consecutive patients were studied. Reflux oesophagitis was seen in

1535 patients, 307 patients had Barrett's oesophagus and a hiatus hernia was

present in 2116 patients. The reference group consisted of 5341 patients. H.

pylori was significantly less often detected in patients with reflux

oesophagitis or Barrett's oesophagus compared with the reference group, 20 vs

29% (p<0.001). Also presence of H. pylori was significantly lower in patients

with hiatus hernia 20 vs 29% (p<0.0001). CONCLUSION: The present study confirms,

in a very large group of patients studied in one single centre, the findings of

earlier papers. Patients without H. pylori gastritis suffer more often from

reflux disease. There is a relation between H. pylori and reflux disease.

However, the consequence of this relation will not be the same in every patient.

PMID: 15460497 [PubMed - indexed for MEDLINE]

1: Am J Gastroenterol. 2002 Feb;97(2):498-9.

Resolution of collagenous colitis after treatment for Helicobacter pylori.

Narayani RI, Burton MP, Young GS.

Publication Types:

Case Reports

Letter

PMID: 11866305 [PubMed - indexed for MEDLINE]

2: Dig Dis. 2001;19(2):170-3.

H. pylori infection and visceral hypersensitivity in patients with irritable

bowel syndrome.

Gerards C, Leodolter A, Glasbrenner B, Malfertheiner P.

Department of Gastroenterology, Hepatology and Infectiology, Otto von Guericke

University, Magdeburg, Germany.

BACKGROUND/AIM: Irritable bowel syndrome (IBS) is characterized by abdominal

pain and changes in stool habits. Visceral hypersensitivity (VH) is a key factor

in the pathophysiology of IBS. The role of Helicobacter pylori infection in the

induction of VH in the upper gastrointestinal tract is controversially

discussed. The aim of this study is to evaluate the value of rectal barostat in

eliciting abdominal symptoms in patients with IBS in relation to H. pylori

infection. PATIENTS AND METHODS: 31 patients (19 female, 12 male, mean age 45.6

+/- 10 years) with normal colonoscopy and clinical signs of IBS were examined by

rectal barostat (pressure-controlled balloon distension in the rectum).

Induction of typical abdominal discomfort (far from the balloon) defined the

examination positive. Level of nonpainful perception (L1), feeling of defecation

(L2), and pain or stool urgency (L3) were registered in comparison with a

healthy control group (CG; n = 15, 9 female, 6 male). The H. pylori status was

defined by (13)C-urea breath test (n = 46). RESULTS: Typical abdominal

discomfort was induced in 9 patients (pain group, PG) by pressure-controlled

rectal distension (H. pylori status: 8 positive, 1 negative). Patients not

presenting with abdominal pain to rectal distension (nonpain group, NPG) were

all H. pylori negative (p < 0.001). L3 as an indicator of VH was reached at a

lower pressure threshold in PG than in NPG or CG (p < 0.05). The perception was

not different between NPG and CG (p > 0.05). CONCLUSIONS: The induction of

typical abdominal discomfort in patients with IBS by the use of rectal barostat

occurred predominantly in H. pylori infected patients and suggests that H.

pylori infection may be involved in triggering VH in patients with IBS. Further

studies in larger patient groups and after H. pylori eradication therapy are

needed to confirm and extend this observation. Copyright 2001 S. Karger AG,

Basel

PMID: 11549828 [PubMed - indexed for MEDLINE]

3: Med Sci Monit. 2001 Jul-Aug;7(4):751-4.

Pseudomembranous colitis after eradication of Helicobacter pylori infection with

a triple therapy.

Harsch IA, Hahn EG, Konturek PC.

1st Department of Medicine, Friedrich- University, Erlangen-Nuremberg,

Erlangen, Germany.

BACKGROUND: H.pylori (H.p.) infection of the gastric mucosa is causally related

to chronic gastritis, peptic ulcer disease, MALT-lymphoma and gastric cancer.

There is also an evidence for a link between the H.p.-infection and non-ulcer

dyspepsia and even extragastric diseases. The number of patients treated against

H.p. infection is expanding. Although in the last years the PPI-based triple

therapies have been considered to be effective and safe, in some patients,

however, severe side-effects may occur. CASE REPORT: We report on a 86 year old

female patient, who received a one-week triple eradication therapy

(metronidazole 3x400 mg/die, clarithromycin 2x250 mg/die and omeprazole 2x20

mg/die) because of non-ulcer dyspepsia. A few days after the eradication

treatment, she developed profuse watery and bloody diarrhea and abdominal pain

with distention. In stool specimens Clostridium difficile toxin was detected. A

colonoscopy showed typical features of antibiotic associated pseudomembranous

colitis. Until now, only few reports concerning this complication have been

published and the frequency of the complication in patients eradicated for H.p.

is unknown. The potential risk factors to develop this condition have not been

clarified. Since the complication may be potentially lethal, this severe

side-effect of the usually well-tolerated triple-therapy has to be considered in

patients suffering from profuse diarrhea and abdominal pain after eradication

therapy.

Publication Types:

Case Reports

PMID: 11433206 [PubMed - indexed for MEDLINE]

4: Am J Gastroenterol. 2000 Aug;95(8):1900-5.

The association between Helicobacter pylori infection and functional dyspepsia

in patients with irritable bowel syndrome.

Su YC, Wang WM, Wang SY, Lu SN, Chen LT, Wu DC, Chen CY, Jan CM, Horowitz M.

Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan.

OBJECTIVE: Irritable bowel syndrome (IBS) is associated with an exaggerated

response to a variety of physiological and nonphysiological gastrointestinal

stimuli. Many patients with IBS also have functional dyspepsia. Our aim was to

examine the hypothesis that Helicobacter pylori (H. pylori) infection may

predispose IBS patients to functional dyspepsia. METHODS: In 69 IBS patients,

dyspeptic symptoms, H. pylori status, and sociodemographic and psychological

variables (perceived stress, trait anxiety, and depression) were assessed.

Sociodemographic and psychological variables were also evaluated in 52 control

subjects. RESULTS: Mean scores for perceived stress (17.1 +/- 6.0 vs 14.9 +/-

6.0, p = 0.05), trait anxiety (45.6 +/- 9.1 vs 41.1 +/- 7.8, p = 0.004) and

depression (9.9 +/- 8.4 vs 5.0 +/- 5.5, p = 0.0002) were higher in IBS patients

than in controls. In all, 33 of the 69 patients (47.8%) had H. pylori infection,

and this was associated with relevant symptoms of epigastric pain (odds ratio

[OR] = 6.77, 95% confidence interval [CI] 1.89-24.3) and postprandial upper

abdominal fullness (OR = 4.23, 95% CI 1.38-13.2). H. pylori infection and female

gender were independent predictors of the presence of relevant dyspepsia (OR =

8.31, 95% CI 2.35-29.5 and 6.06, 95% CI 1.71-21.5, respectively). Symptom

intensity was associated with the level of perceived stress (total relevant

symptom number > or =3 vs <3, OR = 1.16 per point on a 40-point perceived stress

scale, 95% CI 1.01-1.34). CONCLUSIONS: In IBS patients, the presence of

dyspepsia is associated with H. pylori infection, female gender, and perceived

stress.

PMID: 10950033 [PubMed - indexed for MEDLINE]

pdiericxd wrote:

>Hi,

>

>A friend´s daughter had heliobacter pylori show up on her analysis and knows

that it´s

>the bug responsible for ulcers, but is it also a player for autism? What is

the best way to

>treat it if any?

>

>Thanks for any help.

>

> (from Barcelona)

>

>

[Guest guest]

, thank you for these citations. My son was scoped by Dr.

Krigsman last week who seemed sort of surprised to find probable h.

pylori in his stomach (lots of the expected inflammation everywhere

too). We are awaiting biopsy results to confirm. This information is

very important to us. Kim

>

> >Hi,

> >

> >A friend´s daughter had heliobacter pylori show up on her analysis

and knows that it´s

> >the bug responsible for ulcers, but is it also a player for autism?

What is the best way to

> >treat it if any?

> >

> >Thanks for any help.

> >

> > (from Barcelona)

> >

> >