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The recommendations of the diabetes web site are, as is any version of the

low-fat diet, a guaranteed recipe for causing diabetes. And heart failure.

And cancer. And . . .

You get the picture.

For some very good reading on this get a copy of Dr. Schwartzbein's

book, " The Schwartzbein Principle. " It's intended as a weight loss book, but

she explains exactly why the PC (politically correct) diet is killing us.

And what she learned when she first went into practice.

She differs from Atkins in two major ways that I disagree with. One, she

says no one should ever be in ketosis. And, Two, no one should ever eat

salt.

Judith Alta

-----Original Message-----

It's always amazed me that the prescribed diet for

diabetes is so high in carbs and an almost irrational

fear of fats. Would I be far off the mark that anyone

eating a diet mainly of carbs and sugar and fat

substitutes would be more prone to get heart disease?

Esp. someone who has an impaired ablility to process

sugars in the first place?

From the official diabtes web site:

Which foods are unhealthy?

Fat is a nutrient, and you need some fat in your

diet. But too much fat isn't good for anyone. And it

can be very harmful to people with diabetes.

Too much fat or cholesterol may increase the chances

of heart disease and/or hardening of the arteries.

People with diabetes have a greater risk of developing

these diseases than those without diabetes. So, it is

very important that you limit the fat in your diet.

Fat is found in many foods. Red meat, dairy products

(whole milk, cream, cheese, and ice cream), egg yolks,

butter, salad dressings, vegetable oils, and many

desserts are high in fat. To cut down on fat and

cholesterol, you should:

* Choose lean cuts of meat. Remove extra fat.

* Eat more fish and poultry (without the skin).

* Use diet margarine instead of butter.

* Drink low-fat or skim milk.

* Limit the number of eggs you eat to three or four a

week and choose liver only now and then.

Can anyone be trusted who still promotes margarine?

My two cents

Chris

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To answer your (rhetorical, I'm sure) question, NO!!!!!!!!!!!!!!!!!!!!!

This is the diet my mother in law has been on for YEARS (she's had type 2

diabetes for awhile now). Guess what? She survived mild (!!!!) breast

cancer and suffered a stroke that left her partially paralyzed last year.

My husband and I are trying our best to open her eyes, but she equates MDs

with God, so it's an uphill battle. She actually lives near Dr. Bernstein

(of " Dr. Bernstein's Diabetes Solution " )--we bought her the book and hope to

convince her to see him soon. He advocates control of blood sugar through

diet--a proper diet, that is, with lots of FAT and severely limited grain

and starch.

> * Choose lean cuts of meat. Remove extra fat.

> * Eat more fish and poultry (without the skin).

> * Use diet margarine instead of butter.

> * Drink low-fat or skim milk.

> * Limit the number of eggs you eat to three or four a

> week and choose liver only now and then.

>

> Can anyone be trusted who still promotes margarine?

>

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People with diabetes may be more prone to developing heart disease, but if

the basic premise of what causes heart disease is way off, then all the

recommendations are going to be in the wrong direction. I just wonder when

these " health gurus " are going to pull their heads out and pay attention to

the research that shows that fat is not bad.

Well, it was the same with Galileo, he told the mainstream scientist and

leaders that they were wrong about the universe rotating around the earth,

and here he had all this research he had done to prove it and they still

wouldn't accept it.

Michele

Diabetes Diet

> It's always amazed me that the prescribed diet for

> diabetes is so high in carbs and an almost irrational

> fear of fats. Would I be far off the mark that anyone

> eating a diet mainly of carbs and sugar and fat

> substitutes would be more prone to get heart disease?

> Esp. someone who has an impaired ablility to process

> sugars in the first place?

>

> From the official diabtes web site:

> Which foods are unhealthy?

>

> Fat is a nutrient, and you need some fat in your

> diet. But too much fat isn't good for anyone. And it

> can be very harmful to people with diabetes.

>

> Too much fat or cholesterol may increase the chances

> of heart disease and/or hardening of the arteries.

> People with diabetes have a greater risk of developing

> these diseases than those without diabetes. So, it is

> very important that you limit the fat in your diet.

>

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If the " health gurus " you speak of were to admit that fat is where it's at

they would have to admit that they have lied to us lo these many years. And

losing face is not something they want to do.

Also, they would lose a huge portion of their incomes, as I feel they will

anyway, as low-carb takes hold.

People who eat " unhealthy " quantities of animal protein and naturally

saturated animal fats will be healthy people, and will not need to throw

money at the medical and drug establishments.

Judith Alta

-----Original Message-----

People with diabetes may be more prone to developing heart disease, but if

the basic premise of what causes heart disease is way off, then all the

recommendations are going to be in the wrong direction. I just wonder when

these " health gurus " are going to pull their heads out and pay attention to

the research that shows that fat is not bad.

Well, it was the same with Galileo, he told the mainstream scientist and

leaders that they were wrong about the universe rotating around the earth,

and here he had all this research he had done to prove it and they still

wouldn't accept it.

Michele

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Judith-

Unfortunately, as in many fields, the old guard probably has to die off

before the new guard can be fully ascendent. Unfortunately, profits

complicate things a lot further in medicine.

>If the " health gurus " you speak of were to admit that fat is where it's at

>they would have to admit that they have lied to us lo these many years. And

>losing face is not something they want to do.

-

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>

> Well, it was the same with Galileo, he told the mainstream

> scientist and leaders that they were wrong about the universe

> rotating around the earth, and here he had all this research

> he had done to prove it and they still wouldn't accept it.

Well, they did eventually, precisely because he did have

good science to back him up.

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i have a diabetic friend who utilises a polish book. THe name which is

escaping me early today.

However he is on a ratio of 3:1:0.5 of fat/protein/carbs

when he has been able to eat like this ( somtimes cant cook fro himself ect

due to work )

he has been able to ween himself off insulin.

the fats he has are primarily egg yolk, lard and bacon fat

_____

From: Judith Alta K [mailto:jaltak@...]

Sent: Thursday, 18 December 2003 3:15 AM

Subject: RE: Diabetes Diet

The recommendations of the diabetes web site are, as is any version of the

low-fat diet, a guaranteed recipe for causing diabetes. And heart failure.

And cancer. And . . .

You get the picture.

For some very good reading on this get a copy of Dr. Schwartzbein's

book, " The Schwartzbein Principle. " It's intended as a weight loss book, but

she explains exactly why the PC (politically correct) diet is killing us.

And what she learned when she first went into practice.

She differs from Atkins in two major ways that I disagree with. One, she

says no one should ever be in ketosis. And, Two, no one should ever eat

salt.

Judith Alta

-----Original Message-----

It's always amazed me that the prescribed diet for

diabetes is so high in carbs and an almost irrational

fear of fats. Would I be far off the mark that anyone

eating a diet mainly of carbs and sugar and fat

substitutes would be more prone to get heart disease?

Esp. someone who has an impaired ablility to process

sugars in the first place?

>From the official diabtes web site:

Which foods are unhealthy?

Fat is a nutrient, and you need some fat in your

diet. But too much fat isn't good for anyone. And it

can be very harmful to people with diabetes.

Too much fat or cholesterol may increase the chances

of heart disease and/or hardening of the arteries.

People with diabetes have a greater risk of developing

these diseases than those without diabetes. So, it is

very important that you limit the fat in your diet.

Fat is found in many foods. Red meat, dairy products

(whole milk, cream, cheese, and ice cream), egg yolks,

butter, salad dressings, vegetable oils, and many

desserts are high in fat. To cut down on fat and

cholesterol, you should:

* Choose lean cuts of meat. Remove extra fat.

* Eat more fish and poultry (without the skin).

* Use diet margarine instead of butter.

* Drink low-fat or skim milk.

* Limit the number of eggs you eat to three or four a

week and choose liver only now and then.

Can anyone be trusted who still promotes margarine?

My two cents

Chris

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-

I'm guessing that would be either _Homo Optimus_ or _Optimal Nutrition_,

both by Dr. Jan Kwasniewski, a Polish doctor who advocates low-carb

high-fat eating.

>i have a diabetic friend who utilises a polish book. THe name which is

>escaping me early today.

-

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ah yes that is the books he has by Jan :)

ive read homo optimus but not optimal nutrition as my mate has that book in

polish :( ( he is polish himself )

_____

From: Idol [mailto:Idol@...]

Sent: Thursday, 18 December 2003 8:32 AM

Subject: RE: Diabetes Diet

-

I'm guessing that would be either _Homo Optimus_ or _Optimal Nutrition_,

both by Dr. Jan Kwasniewski, a Polish doctor who advocates low-carb

high-fat eating.

>i have a diabetic friend who utilises a polish book. THe name which is

>escaping me early today.

-

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>

> i have a diabetic friend who utilises a polish book. THe

> name which is escaping me early today.

Its probably Dr. Jan Kwasniewski and his " Optimal Diet " .

> However he is on a ratio of 3:1:0.5 of fat/protein/carbs

> when he has been able to eat like this ( somtimes cant cook

> fro himself ect due to work )

>

> he has been able to ween himself off insulin. the fats he

> has are primarily egg yolk, lard and bacon fat

There's some information on Dr. Jan Kwasniewski and his

diet at http://homodiet.netfirms.com/misc/cv_jk.htm .

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In a message dated 12/17/2003 10:50:23 PM Eastern Standard Time,

heidis@... writes:

identified the auto-immune factor that destroys the

pancreas, and it stops getting produced (in the gluten sensitive kids)

when they stop eating gluten. I think there is more to it

than carbs ... after all, the Indians had corn and potatoes before

the Europeans did. (though a higher meat diet has more nutrients,

## I have mentioned this here before but one of my employees has type 2

diabetes and has been able to throw away the insulin by dropping grains and of

course processed sugars from her diet.

She still eats carbs--but not grains and follows NT philosophy for the most

part.

The interesting thing is that she was on insulin and eating this way but it

did not occur to her to drop the insulin. She was stabilized and assumed that

it was at least in part the insulin and not JUST the diet changes.

And even had it occurred to her that it was just the diet changes it would

have been a big leap of faith for her to drop insulin on that chance.

But chance did it for her when her completely irresponsible physician FORGOT

to call in her insulin prescription to her pharmacy on a Friday. So she went

3 days without insulin and had no problems. So when she was able to fill the

prescription the next week she did not and has not since then.

She is also a heavyset person but has lots a lot of weight eating this way,

in addition to being able to ditch the insulin and she has not been actively

dieting.

Alison

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At 07:40 AM 12/18/2003 +1000, you wrote:

>I think their misguided theory is if you are smothering yourself with carbs

>all day then they can control the insulin. Rather than suddenly having a

>carb meal in the day that really " blows stuff out the water "

>

>The problem is medical beelives u ned a certain amount of carb in yoru day

>and they try to fit that in with a diabetic

Am on a Native American diabetes list and have been in a not well taken by

some

at all but not totally ignored presentation of higher fat/protein low carb

dieting for diabetes control. One person from an organization for type l,which

has its own set of more common problems (ketoacidosis and hypoglycemia) than

type ll, uses and suggests hi quality whole grain crackers and bread after

insulin to get it going as it was in a U.S. medical report. If the report was

from a study l found, the study was done in southern Europe and the trial

people were named as all southern Europeans, where grains have been used next

to the longest in history. Gluten intolerance l covered because gluten grains

were not in the Native American diet until the last few hundred years. Few

went

back on Atkins as they were familiar with it. One even asked for a safe carb

level so l suggested Schwarzbein's. I'd posted this acticle sent to this

list about a year ago by Dedy. Just makes sense to me if you're living in

northern latitudes and your ancestry is from the same you can't maintain

health

eating like you live on a tropical island.

Wanita

Lakota man credits traditional diet for diabetes control

By Heidi Bell Gease, Journal Staff Writer

<http://www.rapidcityjournal.com/articles/2003/01/12/news/local/news04>http

://www.rapidcityjournal.com/articles/2003/01/12/news/local/news04.

txt

EAGLE BUTTE - Chasing Hawk is in touch with his triglycerides.

" When my triglycerides goes up, my back of my head hurts, " he

explained, touching his head for emphasis.

Triglycerides are a form of fat found in food. They can provide

energy for the body, but high levels of triglycerides can mean there

is too much fat in the diet. They can also indicate a high risk for

heart disease or poorly controlled diabetes.

Triglycerides aren't the only thing Chasing Hawk, 57, is aware of

within his body. He knows a serving of raisins will raise his blood

sugar by 80 points. He can estimate his cholesterol at any given time.

And he's convinced that eating the higher protein, lower carbohydrate

diet of his ancestors has made him, as he likes to say, " the

healthiest diabetic around. " In fact, Chasing Hawk now relies on diet

and exercise, not insulin, to control his diabetes.

He wasn't always so healthy. About 20 years ago, Chasing Hawk, who

stands 5 feet 8 inches tall, weighed 224 pounds. He was Cheyenne

River Sioux tribal chairman then, " and I was embarrassed about my big

stomach. "

So he began exercising, dropping to 176 pounds. Meanwhile, several

family members were diagnosed with diabetes. " I was proud that I

wasn't diabetic, " he said.

But in 1992, Chasing Hawk's vision became blurry - a common sign of

diabetes. Tests showed his cholesterol was 375, well over the

American Heart Association's " high risk " point of 240 or above. He,

too, was diabetic.

Chasing Hawk became a model patient. He exercised daily and followed

food-pyramid guidelines that encourage a diet heavy in grains (i.e.,

carbohydrates) and low in meat/protein and fat. Yet in late 1997, his

cholesterol was still 294.

" Two weeks later, I had a heart attack, " Chasing Hawk said. Triple

bypass surgery followed.

" I was mad. Because why me? I exercised, " he said. " I followed the

food pyramid. ... I even had my own keys to the fitness room. "

Then, in December 1999, he and his wife, Ernestine, went out for a

steak dinner. Ernestine always told him protein was good for him, he

said, " but I didn't believe her. "

Before dinner, Chasing Hawk's blood sugar was 160. Ninety minutes

later, after eating a big steak, the reading had dropped to 31. " All

that time, " he said, " Ernestine was right. "

Soon afterward, Chasing Hawk ran across a book on carbohydrate

addiction. He stayed up late, reading the whole book straight through.

The next morning, his blood sugar was 140. After a high-protein

breakfast of bacon and eggs, it had dropped to 105.

Chasing Hawk began experimenting and exploring how different foods

affected his body. He checked his blood sugar 15 times a day. He

studied nutrition. Then, he read about the Atkins Diet, which

promotes high protein and low carbohydrate intake.

" I read five chapters, and it clicked in my mind that my ancestors

were a high-protein, low-carbohydrate people, " he said.

Genetically, " Native Americans will have a harder time breaking up

the sugar in carbohydrates. "

Nutritionist Kibbe Conti agrees with that assessment. Indian people

whose ancestors were hunter/gatherers have an atypical response to

carbohydrates, she said, releasing more insulin after eating

carbohydrates than someone whose ancestry is better adapted to that

diet.

Chasing Hawk's move to a more traditional diet fits in well with

Conti's Medicine Wheel nutrition guide (see related story on Page

A1), which is based on the eating habits of pre-reservation-era

tribes.

" Basically, how Bob and I see it, it's a historical diet, " Conti

said. " My whole thing is if you're predominantly Lakota, then you

can't ignore your ancestor foodway. You just can't. "

Chasing Hawk isn't eating just buffalo meat and wild turnips. He

follows what he calls a " traditional diet in modern times. "

He continually asks himself whether the food he's about to eat is

something his ancestors might have eaten. Steak? Yes. Pasta? No.

" My great-great-grandfather didn't eat that bread, so why should I

eat that bread? " he asked.

Chasing Hawk has also found that for him, eating twice as much

protein as carbohydrates helps keep his blood sugar down. That

doesn't mean no carbs, though.

" I still eat my apple pie, " he said. " I still have my ice cream, on

the sneak. "

The trade-off is exercise. Chasing Hawk has monitored his blood sugar

enough to know exactly how a two-mile jog or a brisk walk will affect

his body, which he refers to as " a research center. "

Now, he's ready to spread the word. He speaks at schools and

workshops, encouraging people to take responsibility for their own

health. He would like to see changes in commodity food programs and

the USDA-approved food pyramid.

Chasing Hawk is also starting a diabetes organization called " Ehanni

Lakol Wicounye Piye Yukini Inc., " or " Re-Awakening the Past Lakota

Healthy Lifestyle. " He hopes it eventually could offer inpatient

treatment for diabetics.

Not everyone agrees with Chasing Hawk's theories. Indian Health

Service administrators say his diet plan has not been scientifically

researched and could prove dangerous.

The main concern is that excessive protein can be hard on the

kidneys, which is an extra concern for diabetics whose kidneys are

already stressed.

But Conti believes " excessive " is a relative term. " If you're a white

European ... (a diet like his) might be of high protein to you, " she

said. But if you're a full-blooded Lakota, as Chasing Hawk is, your

body might be accustomed to more protein.

Conti also notes that AIC blood tests show Chasing Hawk's diabetes is

under control. " You can't lie on that test, " she said, because it

measures blood sugar for the past eight weeks. " I totally believe

he's a success story. "

Chasing Hawk says people should check with a doctor before trying his

eating plan. And he says there's something else they need to do.

" If you really want to do it, get connected with that guy, " he said,

pointing skyward. " You gotta ask that guy to walk beside you. "

Contact reporter Heidi Bell Gease at 394-8419 or at heidi.bell@r...

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Wanita,

Thanks for the great article.

The establishment complains that the " Lakota diet " is not scientific. But

neither is the low-fat diet. Yes, it has been tested extensively and those

tests have not proven that it is either safe or healthy.

The low-fat diet has been created to make money for the drug companies, and

no other reason. In that respect it is a rousing success.

Judith Alta

RE: Diabetes Diet

At 07:40 AM 12/18/2003 +1000, you wrote:

>I think their misguided theory is if you are smothering yourself with carbs

>all day then they can control the insulin. Rather than suddenly having a

>carb meal in the day that really " blows stuff out the water "

>

>The problem is medical beelives u ned a certain amount of carb in yoru day

>and they try to fit that in with a diabetic

Am on a Native American diabetes list and have been in a not well taken by

some

at all but not totally ignored presentation of higher fat/protein low carb

dieting for diabetes control. One person from an organization for type

l,which

has its own set of more common problems (ketoacidosis and hypoglycemia) than

type ll, uses and suggests hi quality whole grain crackers and bread after

insulin to get it going as it was in a U.S. medical report. If the report

was

from a study l found, the study was done in southern Europe and the trial

people were named as all southern Europeans, where grains have been used

next

to the longest in history. Gluten intolerance l covered because gluten

grains

were not in the Native American diet until the last few hundred years. Few

went

back on Atkins as they were familiar with it. One even asked for a safe carb

level so l suggested Schwarzbein's. I'd posted this acticle sent to

this

list about a year ago by Dedy. Just makes sense to me if you're living in

northern latitudes and your ancestry is from the same you can't maintain

health

eating like you live on a tropical island.

Wanita

Lakota man credits traditional diet for diabetes control

By Heidi Bell Gease, Journal Staff Writer

<http://www.rapidcityjournal.com/articles/2003/01/12/news/local/news04>http

://www.rapidcityjournal.com/articles/2003/01/12/news/local/news04.

txt

EAGLE BUTTE - Chasing Hawk is in touch with his triglycerides.

" When my triglycerides goes up, my back of my head hurts, " he

explained, touching his head for emphasis.

Triglycerides are a form of fat found in food. They can provide

energy for the body, but high levels of triglycerides can mean there

is too much fat in the diet. They can also indicate a high risk for

heart disease or poorly controlled diabetes.

Triglycerides aren't the only thing Chasing Hawk, 57, is aware of

within his body. He knows a serving of raisins will raise his blood

sugar by 80 points. He can estimate his cholesterol at any given time.

And he's convinced that eating the higher protein, lower carbohydrate

diet of his ancestors has made him, as he likes to say, " the

healthiest diabetic around. " In fact, Chasing Hawk now relies on diet

and exercise, not insulin, to control his diabetes.

He wasn't always so healthy. About 20 years ago, Chasing Hawk, who

stands 5 feet 8 inches tall, weighed 224 pounds. He was Cheyenne

River Sioux tribal chairman then, " and I was embarrassed about my big

stomach. "

So he began exercising, dropping to 176 pounds. Meanwhile, several

family members were diagnosed with diabetes. " I was proud that I

wasn't diabetic, " he said.

But in 1992, Chasing Hawk's vision became blurry - a common sign of

diabetes. Tests showed his cholesterol was 375, well over the

American Heart Association's " high risk " point of 240 or above. He,

too, was diabetic.

Chasing Hawk became a model patient. He exercised daily and followed

food-pyramid guidelines that encourage a diet heavy in grains (i.e.,

carbohydrates) and low in meat/protein and fat. Yet in late 1997, his

cholesterol was still 294.

" Two weeks later, I had a heart attack, " Chasing Hawk said. Triple

bypass surgery followed.

" I was mad. Because why me? I exercised, " he said. " I followed the

food pyramid. ... I even had my own keys to the fitness room. "

Then, in December 1999, he and his wife, Ernestine, went out for a

steak dinner. Ernestine always told him protein was good for him, he

said, " but I didn't believe her. "

Before dinner, Chasing Hawk's blood sugar was 160. Ninety minutes

later, after eating a big steak, the reading had dropped to 31. " All

that time, " he said, " Ernestine was right. "

Soon afterward, Chasing Hawk ran across a book on carbohydrate

addiction. He stayed up late, reading the whole book straight through.

The next morning, his blood sugar was 140. After a high-protein

breakfast of bacon and eggs, it had dropped to 105.

Chasing Hawk began experimenting and exploring how different foods

affected his body. He checked his blood sugar 15 times a day. He

studied nutrition. Then, he read about the Atkins Diet, which

promotes high protein and low carbohydrate intake.

" I read five chapters, and it clicked in my mind that my ancestors

were a high-protein, low-carbohydrate people, " he said.

Genetically, " Native Americans will have a harder time breaking up

the sugar in carbohydrates. "

Nutritionist Kibbe Conti agrees with that assessment. Indian people

whose ancestors were hunter/gatherers have an atypical response to

carbohydrates, she said, releasing more insulin after eating

carbohydrates than someone whose ancestry is better adapted to that

diet.

Chasing Hawk's move to a more traditional diet fits in well with

Conti's Medicine Wheel nutrition guide (see related story on Page

A1), which is based on the eating habits of pre-reservation-era

tribes.

" Basically, how Bob and I see it, it's a historical diet, " Conti

said. " My whole thing is if you're predominantly Lakota, then you

can't ignore your ancestor foodway. You just can't. "

Chasing Hawk isn't eating just buffalo meat and wild turnips. He

follows what he calls a " traditional diet in modern times. "

He continually asks himself whether the food he's about to eat is

something his ancestors might have eaten. Steak? Yes. Pasta? No.

" My great-great-grandfather didn't eat that bread, so why should I

eat that bread? " he asked.

Chasing Hawk has also found that for him, eating twice as much

protein as carbohydrates helps keep his blood sugar down. That

doesn't mean no carbs, though.

" I still eat my apple pie, " he said. " I still have my ice cream, on

the sneak. "

The trade-off is exercise. Chasing Hawk has monitored his blood sugar

enough to know exactly how a two-mile jog or a brisk walk will affect

his body, which he refers to as " a research center. "

Now, he's ready to spread the word. He speaks at schools and

workshops, encouraging people to take responsibility for their own

health. He would like to see changes in commodity food programs and

the USDA-approved food pyramid.

Chasing Hawk is also starting a diabetes organization called " Ehanni

Lakol Wicounye Piye Yukini Inc., " or " Re-Awakening the Past Lakota

Healthy Lifestyle. " He hopes it eventually could offer inpatient

treatment for diabetics.

Not everyone agrees with Chasing Hawk's theories. Indian Health

Service administrators say his diet plan has not been scientifically

researched and could prove dangerous.

The main concern is that excessive protein can be hard on the

kidneys, which is an extra concern for diabetics whose kidneys are

already stressed.

But Conti believes " excessive " is a relative term. " If you're a white

European ... (a diet like his) might be of high protein to you, " she

said. But if you're a full-blooded Lakota, as Chasing Hawk is, your

body might be accustomed to more protein.

Conti also notes that AIC blood tests show Chasing Hawk's diabetes is

under control. " You can't lie on that test, " she said, because it

measures blood sugar for the past eight weeks. " I totally believe

he's a success story. "

Chasing Hawk says people should check with a doctor before trying his

eating plan. And he says there's something else they need to do.

" If you really want to do it, get connected with that guy, " he said,

pointing skyward. " You gotta ask that guy to walk beside you. "

Contact reporter Heidi Bell Gease at 394-8419 or at heidi.bell@r...

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If Indian Health Services took half the salaries of health workers plus

diabetes drug costs and put it into changing food subsidies and correct

dietary, exercise education alone there'd probably be room for a bigger cut

after because diabetics would no longer be the majority of patients.

Boggles my mind that minds that choose to be and make decisions of

leadership cannot think to the point of linking diseases of fat metabolism

to the commercial altering of fats and diabetes to increase in use of

refined carbohydrates.

Wanita

>

>Thanks for the great article.

>

>The establishment complains that the " Lakota diet " is not scientific. But

>neither is the low-fat diet. Yes, it has been tested extensively and those

>tests have not proven that it is either safe or healthy.

>

>The low-fat diet has been created to make money for the drug companies, and

>no other reason. In that respect it is a rousing success.

>

>Judith Alta

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At 03:37 PM 12/17/2003, you wrote:

>) than

>type ll, uses and suggests hi quality whole grain crackers and bread after

>insulin to get it going as it was in a U.S. medical report. If the report was

>from a study l found, the study was done in southern Europe and the trial

>people were named as all southern Europeans, where grains have been used next

>to the longest in history. Gluten intolerance l covered because gluten grains

>were not in the Native American diet until the last few hundred years.

Gluten grains are very much associated with T1 diabetes too. Sounds

like they've identified the auto-immune factor that destroys the

pancreas, and it stops getting produced (in the gluten sensitive kids)

when they stop eating gluten. I think there is more to it

than carbs ... after all, the Indians had corn and potatoes before

the Europeans did. (though a higher meat diet has more nutrients,

it doesn't seem that the Indians had as high a rate of obesity

and diabetes til they got the European foods).

I really wonder about the recommendation to eat small hi-carb

meals for diabetics ... it seems there is some consensus that

insulin resistance comes from eating more carbs when the glycogen

stores are already full. So constantly " topping off " the glycogen

seems intuitively counterproductive, even for the folks that don't believe

in fat.

" When people with diabetes start burning more

calories than they consume, their blood sugar control improves within a mere 24

hours "

Health magazine, nov 2003 -- talking about the feast/fast protocol. They had

diabetics eat " light " now and then, 400-600 caloires for the day -- and their

blood sugar control improved (they also lost more weight than people

on a standard low-cal diet).

-- Heidi

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In a message dated 12/18/2003 2:27:11 AM Eastern Standard Time,

heidis@... writes:

I'm assuming she has a glucose meter though? So when you mean " no problems "

you mean her blood sugar isn't high? If so, then that is WONDERFUL!

@@@ Yes she has a glucose meter and yes, 'no problems' means no high blood

sugar.

Alison

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>But chance did it for her when her completely irresponsible physician FORGOT

>to call in her insulin prescription to her pharmacy on a Friday. So she went

>3 days without insulin and had no problems. So when she was able to fill the

>prescription the next week she did not and has not since then.

>

>She is also a heavyset person but has lots a lot of weight eating this way,

>in addition to being able to ditch the insulin and she has not been actively

>dieting.

>

>Alison

I'm assuming she has a glucose meter though? So when you mean " no problems "

you mean her blood sugar isn't high? If so, then that is WONDERFUL!

I always get nervous when people ditch insulin or blood pressure medication

unless they are monitoring ...

-- Heidi

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Heidi wrote -- in Health magazine, nov 2003 -- talking about the feast/fast

protocol. They had diabetics eat " light " now and then, 400-600 caloires for the

day -- and their blood sugar control improved (they also lost more weight than

people on a standard low-cal diet).

Heidi,

is this article available on line?...TIA

Dedy

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>Heidi wrote -- in Health magazine, nov 2003 -- talking about the feast/fast

protocol. They had diabetics eat " light " now and then, 400-600 caloires for the

day -- and their blood sugar control improved (they also lost more weight than

people on a standard low-cal diet).

>

>Heidi,

>

>is this article available on line?...TIA

>

>Dedy

No, not unless you have a subscription. You can probably check it

out at the library though. The doctor doing that study is ,

maybe you can find something by him (I didn't find much on a web search though,

just

http://www.findarticles.com/cf_0/m0CUH/5_23/64730780/p5/article.jhtml?term=

I expect other magazines will be picking up on the story though, and

they will be online.

Science News this week has an article on " Ketones to the rescue " -- using

ketosis to cure diseases (I haven't read it yet) but THAT isn't online either.

without a subscription. Harsh. Discover is making some articles " Members only "

also.

Time to support your local library ...

-- Heidi

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Here is one that is publically available ...

http://www.sciencenews.org/20030607/food.asp

Intermittent feeding also improved the animals' resistance to a neurotoxin that

simulates Alzheimer's disease, the researchers report in the May 13 Proceedings

of the National Academy of Sciences.

.....

When resting, rats fed only on alternating days had lower heart rates and blood

pressure and less circulating glucose and insulin in their blood than did the

other rats. The sometimes-fasting rats also showed muted cardiovascular

responses to stress, suggesting that they more readily adapt physiologically to

such situations.

-- Heidi

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Heidi wrote -- Time to support your local library ...

thanks for the reply Heidi... unfortunately my local library doesn't carry this

publication... but... as you say, the story will no doubt be soon published

elsewhere...

meanwhile, I'll be practicing being patient :-)

Dedy

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Heidi.

Trying to find another diabetes article l had that linked diabetes to

mainly environmental factors (foods, pollutants, stress, etc.) and secondly

to a starvation gene, which would be aggravated by 3-6 meals day constant

digestion of diabetes/hypoglycemic diets. Backs up the warrior diet

feast/famine and my experience. Highest diabetes statistics have always

been Native Americans, Blacks and Hispanics in this country. Asians have

just recently seen a rise in incidence as someone mentioned in another

post. With type I it could be a mutation, no insulin being produced brought

on possibly by years of gluten sensitivity through generations. Like

Dangerous Grains says, gluten randomly can attack organs.

Wanita

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:

>Trying to find another diabetes article l had that linked diabetes to

>mainly environmental factors (foods, pollutants, stress, etc.) and secondly

>to a starvation gene, which would be aggravated by 3-6 meals day constant

>digestion of diabetes/hypoglycemic diets. Backs up the warrior diet

>feast/famine and my experience.

I esp. liked the part that the fasting experience helps one cope with stress, so

the two get combined.

> Highest diabetes statistics have always

>been Native Americans, Blacks and Hispanics in this country. Asians have

>just recently seen a rise in incidence as someone mentioned in another

>post. With type I it could be a mutation, no insulin being produced brought

>on possibly by years of gluten sensitivity through generations. Like

>Dangerous Grains says, gluten randomly can attack organs.

Gluten does randomly attack organs, but they've found at least one specific

pathway ... See below. Also when they give rats zonulin, which increases

intestinal

permeability, they tend to get T1 diabetes. Gluten sensitive people

secrete zonulin when they get gluten. So it isn't just gluten that gets

into the blood, who knows what other chemicals get involved, plus

the food antibodies that are in the gut (to attack potential food

toxins) get into the blood.

==============

>Patients

>WESTPORT, Sep 07 (Reuters Health) - Patients with celiac disease have

>high levels of diabetes- and thyroid-related autoantibodies that

> " disappear " when the patients are placed on a gluten-free diet.

> The finding confirms the high prevalence of organ-specific

>autoantibodies in patients with celiac disease, and supports the theory

>that these antibodies are gluten-dependent, Dr. Alessandro Ventura, of

>the Universita di Trieste, Italy, and colleagues say in the August issue

>of the Journal of Pediatrics.

> The investigators tested 90 children with celiac disease for serum

>antibodies to islet cells, glutamic acid decarboxylase, insulin, and

>thyroperoxidase. The overall prevalence of diabetes- and thyroid-related

>autoantibodies was 11.1% and 14.4%, respectively.

> Prior studies have suggested that the presence of organ-specific

>autoantibodies in patients with celiac disease is " related to the

>presence of a second autoimmune disease. " However, the fact that serum

>organ-specific autoantibodies tended to disappear in the current study

>when patients were placed on a gluten-free diet supports the position

>that these antibodies are at least partly gluten-dependent.

> " A gluten-free diet started early may prevent the other autoimmune

>diseases frequently associated with celiac disease, " Dr. Ventura and

>colleagues hypothesize. However, further studies will be needed to

>determine the clinical significance of the organ-specific autoantibodies

>in these patients and to confirm this hypothesis.

====================

See also:

http://jama.ama-assn.org/cgi/content/abstract/290/13/1713?etoc

Results Children initially exposed to cereals between ages 0 and 3 months

(hazard ratio


, 4.32; 95% confidence interval [CI], 2.0-9.35) and those who

were exposed at 7 months or older (HR, 5.36; 95% CI, 2.08-13.8) had increased

hazard of IA compared with those who were exposed during the fourth through

sixth month, after adjustment for HLA genotype, family history of type 1 DM,

ethnicity, and maternal age. In children who were positive for the

HLA-DRB1*03/04,DQB8 genotype, adjusted HRs were 5.55 (95% CI, 1.92-16.03) and

12.53 (95% CI, 3.19-49.23) for initial cereal exposure between ages 0 to 3

months and at 7 months or older, respectively.

Conclusion There may be a window of exposure to cereals in infancy outside

which initial exposure increases IA risk in susceptible children.

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Heidi,

Thanks for gluten articles! There are two articles l was referring to it

seems. Excerpt of starvation paragraph here. Doesn't say starvation gene in

second article. Leaves me with 3 square meals a day isn't good when you

look at

ability to survive starvation and ethnicities most prone in first article.

Evolutionary biologists suspect that a predisposition toward diabetes

developed

among certain ethnic groups—such as Pima Indians or Americans of African

descent—as a result of repeated, perhaps even recent, bouts of starvation.

Those individuals who were better able to decrease energy expenditures

during a

famine survived and passed on the trait to their offspring. Unfortunately,

that

ability seems to cause insulin resistance when food is plentiful. In other

words, says Dr. ielsz, director of the Center for Women's Health

Research at New York University, " you come out into the world—at least the

developed world—and there is no shortage of cheap, fast food. Your thrifty

metabolism has prepared you for the wrong future. "

Wanita

Sunday, Nov. 30, 2003

Why So Many of Us Are Getting Diabetes

Never have doctors known so much about how to prevent or control this disease,

yet the epidemic keeps on raging. How you can protect yourself

By CHRISTINE GORMAN

Hillary Carroll knew something was amiss. she had spent Memorial Day happily

frolicking in her grandmother's swimming pool, but by that evening she was

doubling over in pain every time she went to the bathroom. Her mother figured

it was probably an infection and the next day took Hillary, then 10, to the

pediatrician. Instead of getting a prescription for an antibiotic, however,

the

220-lb. youngster was immediately admitted to the hospital. Lab tests showed

that she had something far more serious—Type 2 diabetes.

Hillary is not the first overweight child to learn she has this form of

diabetes, a chronic metabolic disorder that used to be called adult onset but

was renamed in part because so many kids Hillary's age were getting it. As

doctors have repeatedly warned, the U.S. is experiencing a diabetes epidemic.

Some 18 million Americans suffer from one form or another, with 1.3 million

new

cases diagnosed last year—up from 878,000 in 1997. And although Type 2

diabetes

still tends to strike people in their fifth or sixth decade, more children are

getting it, a fact of grave concern to health officials. Not only are these

kids likely to face a lifetime of problems—including higher risks of

blindness,

heart disease and stroke—they are also a warning sign that something in our

way

of life has gone terribly wrong.

And yet scientists in just the past decade have learned that the most

devastating complications of diabetes—and in some cases the disease itself—are

almost entirely preventable. There are better techniques for monitoring

diabetes and more effective drugs for treating it, and a major study published

last year shows that by making only modest changes in diet and exercise,

people

at high risk of Type 2 diabetes can stave off the disease for at least three

years and perhaps a lot longer (more on Type 1 in just a bit).

It's a puzzle. Never have physicians known so much about Type 2 diabetes and

how to control it, yet the number of cases is expected to rise at an alarming

rate. Epidemiologists predict that by 2025 the incidence in the U.S. will

double. Annual treatment costs are projected to rise, from $132 billion to

$192

billion in 2020—not counting inflation. Hardest hit will be certain ethnic

groups—including African Americans and Native Americans, Hispanics and

Asians—that for complicated reasons are more prone to the disorder.

To the dismay of health experts, diabetes is becoming a global problem. In the

next couple of decades, the prevalence of diabetes is expected to triple in

Africa, the eastern Mediterranean, the Middle East and Southeast Asia, to

double in the western Pacific and to nearly double in Europe. With an

estimated

33 million cases, India has the most people with diabetes; China has 23

million.

Lots of doctors will tell you that the reason for the explosion is obvious:

Americans are eating too much and exercising too little, and much of the world

is following our bad example. There is no question that excessive weight

increases your risk of becoming diabetic. But that explains only part of the

problem. Diabetes has a strong genetic component, and scientists are beginning

to suspect that certain evolutionary factors, as well as your mother's

metabolic or nutritional status during pregnancy, may predispose you to

develop

diabetes. That may explain why Indians from the subcontinent often become

diabetic after gaining just a few pounds and why the consequences of obesity

seem far more devastating for Americans of African, as opposed to European,

descent.

A complex picture is emerging that is changing the way we think about what was

already a complex disease. It turns out that patients are not as helpless

against its ravages as was once thought, especially if they are warned at the

disease's very earliest stages. Changes in lifestyle and diet can, in the vast

majority of cases, make a big difference. The future for anyone with diabetes

has never been brighter, provided he or she has access to the right

treatments.

But the consequences of inaction have never been more broadly devastating.

This

year more than 200,000 Americans with diabetes will die from its

complications.

What Is Diabetes?

To understand the latest insights into the disease, it helps to know a little

more about two key molecules—glucose and insulin—and the roles they play in

the

conditions doctors call Type 1 and Type 2 diabetes. We'll start with glucose,

the sugar molecule that is a major source of fuel for the body. You can get

your glucose levels tested at a doctor's office or at home with a device

called

a glucometer. What you're looking for is a reading measured in milligrams of

glucose per deciliter of blood (or, on some glucometers, in millimoles per

liter). Anyone whose glucose level before breakfast—the fasting level—is 126

mg/dL (7 mmol/L) or higher is considered diabetic. A normal fasting level runs

anywhere from 65 mg/dL to just under 100 mg/dL (3.6 mmol/L to 5.6 mmol/L).

Insulin is a hormone made by specialized cells in the pancreas, whose job

is to

push glucose out of the blood into various cells in the body.

Whenever the amount of glucose in the blood starts to rise, which happens just

about whenever you eat, the pancreas pumps out more insulin to keep sugar

levels stable.

Here's where the difference between Type 1 and Type 2 is clearest. Type 1

diabetics have high glucose levels because their pancreas can no longer make

insulin. By definition, Type 1 diabetics must eventually take insulin shots to

get their diabetes under control. Type 2 diabetics can still make their own

insulin, but their bodies don't respond as well to it—a situation called

insulin resistance.

Any scientist who can figure out why Type 2 diabetics are insulin resistant

will probably be a candidate for a Nobel Prize. It's not a simple consequence

of being overweight. Many obese people are not insulin resistant, and not

everyone who is insulin resistant is overweight. Researchers at the Salk

Institute in La Jolla, Calif., believe that at least part of the answer lies

not in the pancreas but in the liver. In a study of mice published in the Nov.

13 issue of Nature, scientists identified a protein that tells the liver to

favor the metabolism of fat over that of glucose. The result is a buildup of

glucose levels in the blood, a hallmark of insulin resistance.

Evolutionary biologists suspect that a predisposition toward diabetes

developed

among certain ethnic groups—such as Pima Indians or Americans of African

descent—as a result of repeated, perhaps even recent, bouts of starvation.

Those individuals who were better able to decrease energy expenditures

during a

famine survived and passed on the trait to their offspring. Unfortunately,

that

ability seems to cause insulin resistance when food is plentiful. In other

words, says Dr. ielsz, director of the Center for Women's Health

Research at New York University, " you come out into the world—at least the

developed world—and there is no shortage of cheap, fast food. Your thrifty

metabolism has prepared you for the wrong future. "

The Sugar Blues

What's so bad about being insulin resistant and having too much glucose in

your

blood? For reasons that researchers are still trying to figure out, having

diabetes greatly increases your risk of suffering a heart attack or a

stroke. A

man with diabetes appears to have the same risk of cardiovascular problems

as a

nondiabetic who has had a heart attack. A woman who develops diabetes loses

the

cardioprotective benefits of being female. And kids with Type 2 diabetes are

more likely to develop heart disease in their 20s and 30s.

The condition also damages small blood vessels throughout the

body—particularly

those in the eyes and kidneys. As many as 24,000 diabetics in the U.S. become

blind each year, more than 100,000 require dialysis or kidney transplantation,

and 82,000 need to have a toe, foot or leg amputated. Diabetics are twice as

likely as nondiabetics to suffer from depression.

It doesn't have to be this way. Back in 1993 doctors proved that Type 1

diabetics could greatly reduce their risk of complications by intensively

managing their glucose levels to keep them as close to normal as possible

(using a glucometer to measure the level of sugar in a pinprick of blood

and an

insulin shot when necessary to bring the level down). Similar results have

since been seen with Type 2 diabetics.

But most Type 2 diabetics don't have to resort to insulin shots to manage

their

condition. Because the fundamental problem in Type 2 diabetes is insulin

resistance—not the inability to produce insulin as in Type 1—other options are

available. Your physician may first give you pills that can either sensitize

your body to insulin's effects or help your body produce more of the hormone.

But some of your best allies in this struggle are your muscles.

Building them up and using them regularly in such pursuits as walking or

dancing draw more glucose out of the bloodstream and increase insulin's

efficiency. It also pays to avoid easily digested foods—like chips, nondiet

soda and other junk food—which require large amounts of insulin to metabolize.

Finally, losing a little weight usually makes insulin's job a lot easier.

Donna Black Bradley, 52, of Los Angeles is living proof. Bradley was driving

home from work one evening when she suddenly was unable to read the freeway

signs. When her doctor diagnosed diabetes, she felt paralyzed. " Then I said

O.K., I got something I got to do here, " Bradley says. " I got to change. " And

change she did. The 5-ft. 7-in. mother and grandmother started eating better

and working out on a treadmill several times a week. Her weight dropped from

272 lbs. to 210 lbs., and her fasting glucose fell from 300 mg/dL to 103

mg/dL.

" It's amazing how your cravings diminish when you're eating the right food

groups, " Bradley says. Her vision problems have disappeared, and her doctor

believes she will no longer need to take insulin-sensitizing drugs if she can

get her weight under 200 lbs.—something she's determined to do, both for

herself and for her grandson Isaiah. Says she: " I want to be around for that

2-year old. "

Small Steps, Big Rewards

The more scientists learn about diabetes and the complications it causes, the

more they find themselves looking at the conditions that precede it. " The big

question now is, When does the diabetes clock start ticking? " says Dr.

Vinicor, director of the diabetes program at the Centers for Disease Control.

" For eye or small-vessel disease, we think the clock starts ticking when blood

sugar starts to go up. But for heart disease, we think the clock may start

ticking much, much earlier, even before the first sign of blood sugar going

up. "

That's why researchers are focusing on a precursor condition called

prediabetes, in which glucose levels are only slightly elevated but which may

put at risk an additional 20 million Americans. In 2002 researchers published

the results of the Diabetes Prevention Program (D.P.P.), one of the largest,

most rigorous clinical trials ever conducted on the subject. More than 3,000

people from all over the U.S. participated. All were overweight, and blood

tests indicated that their bodies were having trouble handling glucose, though

none had yet developed diabetes. Half were from ethnic communities that are at

higher risk. Participants in the D.P.P. were divided into three groups. One

was

given the diabetes drug metformin, one was given a dummy pill, and one was

enrolled in a nutrition and exercise program with the goal for participants to

lose 7% of their initial weight and to exercise 30 minutes a day, five times a

week.

The D.P.P. trial was halted a full year early " because the results were

just so

remarkable, " says Dr. , director of the Diabetes Center at

Massachusetts General Hospital in Boston, who chaired the study. During the

three years of the study, nearly 30% of the placebo group developed diabetes.

For the metformin group the figure was 22%. The subjects who exercised

moderately and lost weight had the lowest incidence of all—just 14%. (The

first

two groups were given diet and exercise information but did not lose as much

weight as the last group.) The study is continuing to see if lifestyle changes

can prevent diabetes for life or merely delay its occurrence. At the very

least, the trial proves that the point of no return is not as early or as

fixed

as was once feared.

Diabetes researchers have been so impressed by the D.P.P. results that many

would like to lower the thresholds that determine who is prediabetic. In

January the American Diabetes Association plans to officially recommend that

physicians consider treating anyone with a fasting glucose of 100 mg/dL or

higher, down from 110 mg/dL or higher in the previous guidelines. " If your

fasting blood sugar is below 100, your chances of getting diabetes are quite

low, " says Dr. Rizza, an endocrinologist at the Mayo Clinic in

Rochester, Minn., and a vice president of the American Diabetes Association.

" But if your fasting glucose is over 100, you have a 10% to 15% chance of

getting diabetes in the next seven years. "

You don't have to convince Tom Marinello, 51, of Carson, Calif., that

prediabetes should be taken seriously. After his father-in-law died of

complications from diabetes, Marinello, unaware that he was at risk, enrolled

in the Diabetes Prevention Program at the University of California, Los

Angeles, hoping to help others with the disease. He was surprised to learn

that

he was prediabetic. By paying closer attention to what he eats and by making

sure to walk nearly every day, Marinello dropped 28 lbs. from his 260-lb.,

6-ft. 1-in. frame, and his fasting-glucose level is down to 110 mg/dL. " I may

still be at risk, but I'm not diabetic, " Marinello says. " I'm kind of proud of

that. "

Beyond Apples and Pears

Is it possible to turn the clock back even further to find who is at greatest

risk of developing prediabetes and lower their risk of future health

problems?

That turns out to be much more complicated.

Cardiologists have long known that if you carry extra weight around your

waist,

which they liken to being shaped like an apple, you are at greater risk of

heart disease. The other configuration, being shaped like a pear, with excess

weight around the hips, doesn't eliminate your risk but seems to lessen it.

Over the years it has become clear that apple-shaped folks have a certain kind

of metabolism: they are more likely to be resistant to insulin, have high

amounts of triglycerides (one of the fatty molecules you don't want too

much of

in your blood) and have low levels of hdl (the " good " cholesterol). They also

tend to have high blood pressure.

Coincidence? Probably not, which is why physicians have lumped all these

symptoms together in one condition that they now call metabolic syndrome. They

believe that anyone with metabolic syndrome is at much greater risk of

developing not just heart disease but diabetes as well. They're not sure

whether there is a primary trigger for metabolic syndrome—say, obesity or

insulin resistance—or if several biological pathways are involved.

Whatever the case, says Dr. Grundy, a leading expert on cholesterol who

chaired the American Heart Association's first clinical conference on

metabolic

syndrome in September, " right now there's no single drug that can treat the

whole metabolic syndrome. " Individual symptoms like high blood pressure still

have to be treated separately. But your best bet for an overall solution is to

eat better, lose weight and get more exercise.

An Inflammatory Question

As central as insulin resistance has become to understanding Type 2 diabetes,

scientists are starting to wonder whether another factor, the inflammatory

response, may also play a key role. Inflammation is a complex biological

process the immune system uses to limit the damage caused by various injuries.

(Ever notice how a turned ankle swells or a sunburn feels warm to the touch?

That's inflammation in action.) But when inflammation becomes chronic, it no

longer limits damage. In fact, it starts to do harm to the body.

Over the past five years, researchers have shown that inflammation is at least

as important as high cholesterol levels in causing heart disease. (High levels

in the blood of certain molecules, such as C-reactive protein (CRP),

indicate a

runaway inflammatory process and are better predictors of heart attacks than

cholesterol.) Could the same be true for diabetes? " In 2001, when we published

our first paper on inflammation and diabetes, everybody thought we were just

wrong, " recalls Dr. Ridker, a cardiologist at Brigham & Women's Hospital

in Boston. " Now there are half a dozen studies confirming that if you measure

markers of inflammation, and CRP in particular, you can do a good job of

predicting who's going to get diabetes. "

If these results are confirmed and inflammation turns out to be as

important as

insulin resistance in triggering diabetes, then it should become much

easier to

identify incipient problems in metabolism before they get out of control. Why?

Because inflammation is much easier to measure than insulin resistance; all

that is required is a single blood test. (Abnormal glucose levels only suggest

the possibility of insulin resistance; they don't prove it. Insulin resistance

is difficult to measure directly.) It might also mean that anti-inflammatory

agents like aspirin may be particularly effective in diabetics.

An Ounce of Prevention

Advances in diabetes research over the past few years have been swift and wide

ranging. Scientists are beginning to identify the genetic and environmental

factors that predispose some people to insulin resistance and increase their

risk of diabetes. They are looking beyond glucose levels to gauge patients'

health and progress. They have identified other pathways that may play a role

in triggering diabetes. Every new insight into Type 2 diabetes, from its

biochemistry to its metabolic roots, makes clear that it can be avoided—and

that the earlier you intervene the better.

The real question is whether we as a society are up to the challenge. " Our

health-care system is currently set up to deliver care for acute disease, "

says

Ann Albright, chief of the California Diabetes Prevention and Control Program.

" It's get in, get your shot, and away you go. " Diabetes, however, is a chronic

disorder that demands constant attention. You have to change your eating

habits

and incorporate physical exercise into each day's activities. You need to

monitor your glucose levels several times a day to see how well you're doing.

These prevention measures pay off in the long run in fewer heart attacks,

strokes, amputations and cases of blindness and kidney failure. But very few

insurance programs focus on them—or pay for health professionals who can teach

folks how best to incorporate them into their lives.

Comprehensive prevention programs aren't cheap, but the cost of doing nothing

is far greater. " If we don't take care of this issue now, we will have huge

numbers of Type 2 diabetics, and we will be paying for them with our tax

dollars, " says Dr. Phyllis Preciado, an internist who runs a diabetes

clinic in

California's farming-rich Central Valley. As the U.S. loses productive members

of the work force, she notes, more people will turn to public assistance for

treatment. And the increased toll in human suffering will be staggering.

There are ways to keep costs down. It doesn't take a physician to teach a

patient the principles of better nutrition or how to use a glucometer. Nurses,

nutritionists, diabetes educators and other non-M.D.s can play a key role.

Experts say it's important to reach the communities that are hardest hit by

diabetes—American Indians, for example—all the while taking cultural

differences into account. " You can't give everybody the same diet to solve the

problem, " says Albright, a registered dietitian. " People obviously eat the

foods they've grown up with. So you have to try to help them get as much of

those things that they like into their eating plan but also make the changes

that will help lower the fat or moderate the carbohydrates. "

Hillary Carroll and her family have taken those lessons to heart. While still

in the hospital, Hillary went through a kind of diabetes boot camp in which

she

learned how to monitor her blood-sugar levels, change the way she eats and

boost the amount of physical activity in her life. Her parents bought her a

turquoise BMX bike, which she rides at least an hour every day. She has

lost 24

lbs. so far, and her glucose levels have stabilized. " Before she was

diagnosed,

she was happy to sit here by herself, playing with her Barbies, " says Tammy

Carroll, Hillary's mother. " I thought she was so calm then, but now that we

have her sugar under control, she's more active. " Hillary, now 11, is taking

charge of her life. To get control of the diabetes epidemic, the rest of us

may

have to do the same.

—Reported by Bjerklie and Alice Park/New York, Dan Cray/ Los Angeles and

Randall/ Cincinnati

http://www.time.com/time/magazine/printout/0,8816,552059,00.html

Diabetes Genes Stacking Up

Gabe Romain

Betterhumans Staff

Tuesday, December 02, 2003, 4:58:33 PM CT

The linkage of eight genes to type 2 diabetes has provided support for the

theory that an accumulation of many small genetic variations makes people

susceptible to the disease.

Researcher Inês Barroso and colleagues at the University of Cambridge in

the UK

found the genes while correlating genetic variations with metabolic changes

characteristic of diabetes.

The researchers analyzed 71 genes in more than 2,000 people and found that

eight of the 71 were linked to type 2 diabetes.

Major health problem

Diabetes is a disease that impairs the body's ability to use glucose, a sugar

that is a cell's main source of energy.

Also known as adult onset diabetes, type 2 diabetes is the most common form of

the disease.

In type 2 diabetes, either the pancreas doesn't produce enough insulin—a

hormone that regulates levels of glucose in the blood—or tissues become

resistant to the action of the hormone.

Type 2 diabetes is a major health problem affecting more than 100 million

people worldwide.

While the influence of environmental factors such as obesity and lifestyle on

the disease's development has been well documented, genetic components have

proven more elusive.

Understanding such components could lead to more effective prevention and

treatment.

Multiple factors

The researchers report that most of the genes they linked to type 2 diabetes

are related to B cells—cells that are responsible for the production of

antibodies—and not to insulin function.

This may suggest that dysfunctions associated with type 2 diabetes are

affected

differently by environmental and genetic factors, with insulin resistance

related more to environmental factors and problems with insulin secretion

related more to genetic factors.

The findings also suggest that large-scale gene screening studies are a good

way to identify a multitude of disease-associated genes that individually

exert

weak effects.

The research is reported in the journal PLoS Biology (read full text).

http://www.betterhumans.com/News/news.aspx?articleID=2003-12-02-2

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" Any scientist who can figure out why Type 2 diabetics are insulin resistant

will probably be a candidate for a Nobel Prize. "

Dr. Atkins, Dr. Schwarzbein and the Drs. Eades, among others, have the

answer, but I'm not aware that any of them have received a Nobel Prize.

Anyone see anything wrong with these two articles?

Nowhere is it mentioned that our low nutrient, fake food, junk food diet is

to blame for diabetes.

Nowhere is it mentioned that eating whole, non-commercially processed food

will help to prevent diabetes.

The only good part was the bit about exercise.

I'm sure I'm not the only one to have noticed that these types of articles

never, or almost never, point their fingers at the garbage the government is

pressuring everyone to eat. Sure wouldn't want to make their advertisers and

supporters unhappy.

Billions of dollars are made each year from diabetes treatments and

paraphernalia. The people who rake in that money sure don't want a " cure " or

prevention unless it's everyone taking prescription drugs from birth to

death

Judith Alta

-----Original Message-----

Heidi,

Thanks for gluten articles! There are two articles l was referring to it

seems. Excerpt of starvation paragraph here. Doesn't say starvation gene in

second article. Leaves me with 3 square meals a day isn't good when you

look at

ability to survive starvation and ethnicities most prone in first article.

Evolutionary biologists suspect that a predisposition toward diabetes

developed

among certain ethnic groups-such as Pima Indians or Americans of African

descent-as a result of repeated, perhaps even recent, bouts of starvation.

Those individuals who were better able to decrease energy expenditures

during a

famine survived and passed on the trait to their offspring. Unfortunately,

that

ability seems to cause insulin resistance when food is plentiful. In other

words, says Dr. ielsz, director of the Center for Women's Health

Research at New York University, " you come out into the world-at least the

developed world-and there is no shortage of cheap, fast food. Your thrifty

metabolism has prepared you for the wrong future. "

Wanita

Sunday, Nov. 30, 2003

Why So Many of Us Are Getting Diabetes

Never have doctors known so much about how to prevent or control this

disease,

yet the epidemic keeps on raging. How you can protect yourself

By CHRISTINE GORMAN

Hillary Carroll knew something was amiss. she had spent Memorial Day happily

frolicking in her grandmother's swimming pool, but by that evening she was

doubling over in pain every time she went to the bathroom. Her mother

figured

it was probably an infection and the next day took Hillary, then 10, to the

pediatrician. Instead of getting a prescription for an antibiotic, however,

the

220-lb. youngster was immediately admitted to the hospital. Lab tests showed

that she had something far more serious-Type 2 diabetes.

Hillary is not the first overweight child to learn she has this form of

diabetes, a chronic metabolic disorder that used to be called adult onset

but

was renamed in part because so many kids Hillary's age were getting it. As

doctors have repeatedly warned, the U.S. is experiencing a diabetes

epidemic.

Some 18 million Americans suffer from one form or another, with 1.3 million

new

cases diagnosed last year-up from 878,000 in 1997. And although Type 2

diabetes

still tends to strike people in their fifth or sixth decade, more children

are

getting it, a fact of grave concern to health officials. Not only are these

kids likely to face a lifetime of problems-including higher risks of

blindness,

heart disease and stroke-they are also a warning sign that something in our

way

of life has gone terribly wrong.

And yet scientists in just the past decade have learned that the most

devastating complications of diabetes-and in some cases the disease

itself-are

almost entirely preventable. There are better techniques for monitoring

diabetes and more effective drugs for treating it, and a major study

published

last year shows that by making only modest changes in diet and exercise,

people

at high risk of Type 2 diabetes can stave off the disease for at least three

years and perhaps a lot longer (more on Type 1 in just a bit).

It's a puzzle. Never have physicians known so much about Type 2 diabetes and

how to control it, yet the number of cases is expected to rise at an

alarming

rate. Epidemiologists predict that by 2025 the incidence in the U.S. will

double. Annual treatment costs are projected to rise, from $132 billion to

$192

billion in 2020-not counting inflation. Hardest hit will be certain ethnic

groups-including African Americans and Native Americans, Hispanics and

Asians-that for complicated reasons are more prone to the disorder.

To the dismay of health experts, diabetes is becoming a global problem. In

the

next couple of decades, the prevalence of diabetes is expected to triple in

Africa, the eastern Mediterranean, the Middle East and Southeast Asia, to

double in the western Pacific and to nearly double in Europe. With an

estimated

33 million cases, India has the most people with diabetes; China has 23

million.

Lots of doctors will tell you that the reason for the explosion is obvious:

Americans are eating too much and exercising too little, and much of the

world

is following our bad example. There is no question that excessive weight

increases your risk of becoming diabetic. But that explains only part of the

problem. Diabetes has a strong genetic component, and scientists are

beginning

to suspect that certain evolutionary factors, as well as your mother's

metabolic or nutritional status during pregnancy, may predispose you to

develop

diabetes. That may explain why Indians from the subcontinent often become

diabetic after gaining just a few pounds and why the consequences of obesity

seem far more devastating for Americans of African, as opposed to European,

descent.

A complex picture is emerging that is changing the way we think about what

was

already a complex disease. It turns out that patients are not as helpless

against its ravages as was once thought, especially if they are warned at

the

disease's very earliest stages. Changes in lifestyle and diet can, in the

vast

majority of cases, make a big difference. The future for anyone with

diabetes

has never been brighter, provided he or she has access to the right

treatments.

But the consequences of inaction have never been more broadly devastating.

This

year more than 200,000 Americans with diabetes will die from its

complications.

What Is Diabetes?

To understand the latest insights into the disease, it helps to know a

little

more about two key molecules-glucose and insulin-and the roles they play in

the

conditions doctors call Type 1 and Type 2 diabetes. We'll start with

glucose,

the sugar molecule that is a major source of fuel for the body. You can get

your glucose levels tested at a doctor's office or at home with a device

called

a glucometer. What you're looking for is a reading measured in milligrams of

glucose per deciliter of blood (or, on some glucometers, in millimoles per

liter). Anyone whose glucose level before breakfast-the fasting level-is 126

mg/dL (7 mmol/L) or higher is considered diabetic. A normal fasting level

runs

anywhere from 65 mg/dL to just under 100 mg/dL (3.6 mmol/L to 5.6 mmol/L).

Insulin is a hormone made by specialized cells in the pancreas, whose job

is to

push glucose out of the blood into various cells in the body.

Whenever the amount of glucose in the blood starts to rise, which happens

just

about whenever you eat, the pancreas pumps out more insulin to keep sugar

levels stable.

Here's where the difference between Type 1 and Type 2 is clearest. Type 1

diabetics have high glucose levels because their pancreas can no longer make

insulin. By definition, Type 1 diabetics must eventually take insulin shots

to

get their diabetes under control. Type 2 diabetics can still make their own

insulin, but their bodies don't respond as well to it-a situation called

insulin resistance.

Any scientist who can figure out why Type 2 diabetics are insulin resistant

will probably be a candidate for a Nobel Prize. It's not a simple

consequence

of being overweight. Many obese people are not insulin resistant, and not

everyone who is insulin resistant is overweight. Researchers at the Salk

Institute in La Jolla, Calif., believe that at least part of the answer lies

not in the pancreas but in the liver. In a study of mice published in the

Nov.

13 issue of Nature, scientists identified a protein that tells the liver to

favor the metabolism of fat over that of glucose. The result is a buildup of

glucose levels in the blood, a hallmark of insulin resistance.

Evolutionary biologists suspect that a predisposition toward diabetes

developed

among certain ethnic groups-such as Pima Indians or Americans of African

descent-as a result of repeated, perhaps even recent, bouts of starvation.

Those individuals who were better able to decrease energy expenditures

during a

famine survived and passed on the trait to their offspring. Unfortunately,

that

ability seems to cause insulin resistance when food is plentiful. In other

words, says Dr. ielsz, director of the Center for Women's Health

Research at New York University, " you come out into the world-at least the

developed world-and there is no shortage of cheap, fast food. Your thrifty

metabolism has prepared you for the wrong future. "

The Sugar Blues

What's so bad about being insulin resistant and having too much glucose in

your

blood? For reasons that researchers are still trying to figure out, having

diabetes greatly increases your risk of suffering a heart attack or a

stroke. A

man with diabetes appears to have the same risk of cardiovascular problems

as a

nondiabetic who has had a heart attack. A woman who develops diabetes loses

the

cardioprotective benefits of being female. And kids with Type 2 diabetes are

more likely to develop heart disease in their 20s and 30s.

The condition also damages small blood vessels throughout the

body-particularly

those in the eyes and kidneys. As many as 24,000 diabetics in the U.S.

become

blind each year, more than 100,000 require dialysis or kidney

transplantation,

and 82,000 need to have a toe, foot or leg amputated. Diabetics are twice as

likely as nondiabetics to suffer from depression.

It doesn't have to be this way. Back in 1993 doctors proved that Type 1

diabetics could greatly reduce their risk of complications by intensively

managing their glucose levels to keep them as close to normal as possible

(using a glucometer to measure the level of sugar in a pinprick of blood

and an

insulin shot when necessary to bring the level down). Similar results have

since been seen with Type 2 diabetics.

But most Type 2 diabetics don't have to resort to insulin shots to manage

their

condition. Because the fundamental problem in Type 2 diabetes is insulin

resistance-not the inability to produce insulin as in Type 1-other options

are

available. Your physician may first give you pills that can either sensitize

your body to insulin's effects or help your body produce more of the

hormone.

But some of your best allies in this struggle are your muscles.

Building them up and using them regularly in such pursuits as walking or

dancing draw more glucose out of the bloodstream and increase insulin's

efficiency. It also pays to avoid easily digested foods-like chips, nondiet

soda and other junk food-which require large amounts of insulin to

metabolize.

Finally, losing a little weight usually makes insulin's job a lot easier.

Donna Black Bradley, 52, of Los Angeles is living proof. Bradley was driving

home from work one evening when she suddenly was unable to read the freeway

signs. When her doctor diagnosed diabetes, she felt paralyzed. " Then I said

O.K., I got something I got to do here, " Bradley says. " I got to change. "

And

change she did. The 5-ft. 7-in. mother and grandmother started eating better

and working out on a treadmill several times a week. Her weight dropped from

272 lbs. to 210 lbs., and her fasting glucose fell from 300 mg/dL to 103

mg/dL.

" It's amazing how your cravings diminish when you're eating the right food

groups, " Bradley says. Her vision problems have disappeared, and her doctor

believes she will no longer need to take insulin-sensitizing drugs if she

can

get her weight under 200 lbs.-something she's determined to do, both for

herself and for her grandson Isaiah. Says she: " I want to be around for that

2-year old. "

Small Steps, Big Rewards

The more scientists learn about diabetes and the complications it causes,

the

more they find themselves looking at the conditions that precede it. " The

big

question now is, When does the diabetes clock start ticking? " says Dr.

Vinicor, director of the diabetes program at the Centers for Disease

Control.

" For eye or small-vessel disease, we think the clock starts ticking when

blood

sugar starts to go up. But for heart disease, we think the clock may start

ticking much, much earlier, even before the first sign of blood sugar going

up. "

That's why researchers are focusing on a precursor condition called

prediabetes, in which glucose levels are only slightly elevated but which

may

put at risk an additional 20 million Americans. In 2002 researchers

published

the results of the Diabetes Prevention Program (D.P.P.), one of the largest,

most rigorous clinical trials ever conducted on the subject. More than 3,000

people from all over the U.S. participated. All were overweight, and blood

tests indicated that their bodies were having trouble handling glucose,

though

none had yet developed diabetes. Half were from ethnic communities that are

at

higher risk. Participants in the D.P.P. were divided into three groups. One

was

given the diabetes drug metformin, one was given a dummy pill, and one was

enrolled in a nutrition and exercise program with the goal for participants

to

lose 7% of their initial weight and to exercise 30 minutes a day, five times

a

week.

The D.P.P. trial was halted a full year early " because the results were

just so

remarkable, " says Dr. , director of the Diabetes Center at

Massachusetts General Hospital in Boston, who chaired the study. During the

three years of the study, nearly 30% of the placebo group developed

diabetes.

For the metformin group the figure was 22%. The subjects who exercised

moderately and lost weight had the lowest incidence of all-just 14%. (The

first

two groups were given diet and exercise information but did not lose as much

weight as the last group.) The study is continuing to see if lifestyle

changes

can prevent diabetes for life or merely delay its occurrence. At the very

least, the trial proves that the point of no return is not as early or as

fixed

as was once feared.

Diabetes researchers have been so impressed by the D.P.P. results that many

would like to lower the thresholds that determine who is prediabetic. In

January the American Diabetes Association plans to officially recommend that

physicians consider treating anyone with a fasting glucose of 100 mg/dL or

higher, down from 110 mg/dL or higher in the previous guidelines. " If your

fasting blood sugar is below 100, your chances of getting diabetes are quite

low, " says Dr. Rizza, an endocrinologist at the Mayo Clinic in

Rochester, Minn., and a vice president of the American Diabetes Association.

" But if your fasting glucose is over 100, you have a 10% to 15% chance of

getting diabetes in the next seven years. "

You don't have to convince Tom Marinello, 51, of Carson, Calif., that

prediabetes should be taken seriously. After his father-in-law died of

complications from diabetes, Marinello, unaware that he was at risk,

enrolled

in the Diabetes Prevention Program at the University of California, Los

Angeles, hoping to help others with the disease. He was surprised to learn

that

he was prediabetic. By paying closer attention to what he eats and by making

sure to walk nearly every day, Marinello dropped 28 lbs. from his 260-lb.,

6-ft. 1-in. frame, and his fasting-glucose level is down to 110 mg/dL. " I

may

still be at risk, but I'm not diabetic, " Marinello says. " I'm kind of proud

of

that. "

Beyond Apples and Pears

Is it possible to turn the clock back even further to find who is at

greatest

risk of developing prediabetes and lower their risk of future health

problems?

That turns out to be much more complicated.

Cardiologists have long known that if you carry extra weight around your

waist,

which they liken to being shaped like an apple, you are at greater risk of

heart disease. The other configuration, being shaped like a pear, with

excess

weight around the hips, doesn't eliminate your risk but seems to lessen it.

Over the years it has become clear that apple-shaped folks have a certain

kind

of metabolism: they are more likely to be resistant to insulin, have high

amounts of triglycerides (one of the fatty molecules you don't want too

much of

in your blood) and have low levels of hdl (the " good " cholesterol). They

also

tend to have high blood pressure.

Coincidence? Probably not, which is why physicians have lumped all these

symptoms together in one condition that they now call metabolic syndrome.

They

believe that anyone with metabolic syndrome is at much greater risk of

developing not just heart disease but diabetes as well. They're not sure

whether there is a primary trigger for metabolic syndrome-say, obesity or

insulin resistance-or if several biological pathways are involved.

Whatever the case, says Dr. Grundy, a leading expert on cholesterol

who

chaired the American Heart Association's first clinical conference on

metabolic

syndrome in September, " right now there's no single drug that can treat the

whole metabolic syndrome. " Individual symptoms like high blood pressure

still

have to be treated separately. But your best bet for an overall solution is

to

eat better, lose weight and get more exercise.

An Inflammatory Question

As central as insulin resistance has become to understanding Type 2

diabetes,

scientists are starting to wonder whether another factor, the inflammatory

response, may also play a key role. Inflammation is a complex biological

process the immune system uses to limit the damage caused by various

injuries.

(Ever notice how a turned ankle swells or a sunburn feels warm to the touch?

That's inflammation in action.) But when inflammation becomes chronic, it no

longer limits damage. In fact, it starts to do harm to the body.

Over the past five years, researchers have shown that inflammation is at

least

as important as high cholesterol levels in causing heart disease. (High

levels

in the blood of certain molecules, such as C-reactive protein (CRP),

indicate a

runaway inflammatory process and are better predictors of heart attacks than

cholesterol.) Could the same be true for diabetes? " In 2001, when we

published

our first paper on inflammation and diabetes, everybody thought we were just

wrong, " recalls Dr. Ridker, a cardiologist at Brigham & Women's

Hospital

in Boston. " Now there are half a dozen studies confirming that if you

measure

markers of inflammation, and CRP in particular, you can do a good job of

predicting who's going to get diabetes. "

If these results are confirmed and inflammation turns out to be as

important as

insulin resistance in triggering diabetes, then it should become much

easier to

identify incipient problems in metabolism before they get out of control.

Why?

Because inflammation is much easier to measure than insulin resistance; all

that is required is a single blood test. (Abnormal glucose levels only

suggest

the possibility of insulin resistance; they don't prove it. Insulin

resistance

is difficult to measure directly.) It might also mean that anti-inflammatory

agents like aspirin may be particularly effective in diabetics.

An Ounce of Prevention

Advances in diabetes research over the past few years have been swift and

wide

ranging. Scientists are beginning to identify the genetic and environmental

factors that predispose some people to insulin resistance and increase their

risk of diabetes. They are looking beyond glucose levels to gauge patients'

health and progress. They have identified other pathways that may play a

role

in triggering diabetes. Every new insight into Type 2 diabetes, from its

biochemistry to its metabolic roots, makes clear that it can be avoided-and

that the earlier you intervene the better.

The real question is whether we as a society are up to the challenge. " Our

health-care system is currently set up to deliver care for acute disease, "

says

Ann Albright, chief of the California Diabetes Prevention and Control

Program.

" It's get in, get your shot, and away you go. " Diabetes, however, is a

chronic

disorder that demands constant attention. You have to change your eating

habits

and incorporate physical exercise into each day's activities. You need to

monitor your glucose levels several times a day to see how well you're

doing.

These prevention measures pay off in the long run in fewer heart attacks,

strokes, amputations and cases of blindness and kidney failure. But very few

insurance programs focus on them-or pay for health professionals who can

teach

folks how best to incorporate them into their lives.

Comprehensive prevention programs aren't cheap, but the cost of doing

nothing

is far greater. " If we don't take care of this issue now, we will have huge

numbers of Type 2 diabetics, and we will be paying for them with our tax

dollars, " says Dr. Phyllis Preciado, an internist who runs a diabetes

clinic in

California's farming-rich Central Valley. As the U.S. loses productive

members

of the work force, she notes, more people will turn to public assistance for

treatment. And the increased toll in human suffering will be staggering.

There are ways to keep costs down. It doesn't take a physician to teach a

patient the principles of better nutrition or how to use a glucometer.

Nurses,

nutritionists, diabetes educators and other non-M.D.s can play a key role.

Experts say it's important to reach the communities that are hardest hit by

diabetes-American Indians, for example-all the while taking cultural

differences into account. " You can't give everybody the same diet to solve

the

problem, " says Albright, a registered dietitian. " People obviously eat the

foods they've grown up with. So you have to try to help them get as much of

those things that they like into their eating plan but also make the changes

that will help lower the fat or moderate the carbohydrates. "

Hillary Carroll and her family have taken those lessons to heart. While

still

in the hospital, Hillary went through a kind of diabetes boot camp in which

she

learned how to monitor her blood-sugar levels, change the way she eats and

boost the amount of physical activity in her life. Her parents bought her a

turquoise BMX bike, which she rides at least an hour every day. She has

lost 24

lbs. so far, and her glucose levels have stabilized. " Before she was

diagnosed,

she was happy to sit here by herself, playing with her Barbies, " says Tammy

Carroll, Hillary's mother. " I thought she was so calm then, but now that we

have her sugar under control, she's more active. " Hillary, now 11, is taking

charge of her life. To get control of the diabetes epidemic, the rest of us

may

have to do the same.

-Reported by Bjerklie and Alice Park/New York, Dan Cray/ Los Angeles

and

Randall/ Cincinnati

http://www.time.com/time/magazine/printout/0,8816,552059,00.html

Diabetes Genes Stacking Up

Gabe Romain

Betterhumans Staff

Tuesday, December 02, 2003, 4:58:33 PM CT

The linkage of eight genes to type 2 diabetes has provided support for the

theory that an accumulation of many small genetic variations makes people

susceptible to the disease.

Researcher Inês Barroso and colleagues at the University of Cambridge in

the UK

found the genes while correlating genetic variations with metabolic changes

characteristic of diabetes.

The researchers analyzed 71 genes in more than 2,000 people and found that

eight of the 71 were linked to type 2 diabetes.

Major health problem

Diabetes is a disease that impairs the body's ability to use glucose, a

sugar

that is a cell's main source of energy.

Also known as adult onset diabetes, type 2 diabetes is the most common form

of

the disease.

In type 2 diabetes, either the pancreas doesn't produce enough insulin-a

hormone that regulates levels of glucose in the blood-or tissues become

resistant to the action of the hormone.

Type 2 diabetes is a major health problem affecting more than 100 million

people worldwide.

While the influence of environmental factors such as obesity and lifestyle

on

the disease's development has been well documented, genetic components have

proven more elusive.

Understanding such components could lead to more effective prevention and

treatment.

Multiple factors

The researchers report that most of the genes they linked to type 2 diabetes

are related to B cells-cells that are responsible for the production of

antibodies-and not to insulin function.

This may suggest that dysfunctions associated with type 2 diabetes are

affected

differently by environmental and genetic factors, with insulin resistance

related more to environmental factors and problems with insulin secretion

related more to genetic factors.

The findings also suggest that large-scale gene screening studies are a good

way to identify a multitude of disease-associated genes that individually

exert

weak effects.

The research is reported in the journal PLoS Biology (read full text).

http://www.betterhumans.com/News/news.aspx?articleID=2003-12-02-2

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