Studies Silicone & Saline

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Studies Silicone & Saline

Studies of silicone breast implants

Plaintiffs' Science Submission to National Science

Pane TABLE OF CONTENTS

A must read for doctor or anyone else.

1994doc.html 1994 DOCUMENT -- SILICONE IMPLANT

CONTROVERSY CONTINUES

300sympt.html CLINICAL FEATURES OF LOCAL BREAST

PHENOMENA IN 300 SYMPTOMATIC RECIPIENTS OF SILICONE

GEL-FILLED BREAST IMPLANTS ARTHUR E. BRAWER

A comparison of autoantibody production in

asymptomatic and symptomatic women with silicone

breast implants. J Rheumatol, 1999 Jan, 26:1, 73-7 The

objective of this study was to investigate the

frequency of autoantibody production in asymptomatic

compared to symptomatic women with silicone implants.

The development of autoantibodies may be related to

implant duration.

a_profile_of_symptomatic_patient.htm A PROFILE OF

SYMPTOMATIC PATIENTS WITH SILICONE BREAST IMPLANTS: A

SJOGRENS-LIKE SYNDROME Freundlich B; Altman C;

Snadorfi N; Greenberg M; Tomaszewski J Graduate

Hospital, Philadelphia, PA 19146. Semin Arthritis

Rheum, 1994 Aug, 24:1 Suppl 1, 44-53

adjuvancy_effect_of_different_ty.htm AdJuvancy effect

of different types of silicone gel. Naim JO; Ippolito

KM; van Oss CJ

adjuvant_effect_of_silicone.htm The adjuvant effect

of silicone-gel on antibody formation in rats. Naim

JO; Lanzafame RJ; van Oss CJ Department of Surgery,

Rochester General Hospital, New York 14621. Immunol

Invest, 22:151-61, 1993 Mar

aim1.html Reported Complications of Silicone Gel

Breast Implants: An Epidemiologic Review Barbara G.

Silverman, MD, MPH; S. Lori Brown, PhD, MPH; lie

A. Bright, ScD; G. Kaezmarek, MD, MPH; Janet B.

Arrowsmith-Lowe, MD; and A. Kessler, MD

american_j_of_pathology.htm American J of Pathology,

Vol. 152 #3: 645-649 Short Communication Low Molecular

Weight Silicones are Widely Distributed after a Single

Subcutaneous Injection in Mice Subbarao V. Kala*

Ernest D. Lykissa* W. Neely* and W.

Lieberman*+ From the Depts of Pathology* and Cell

Biology+. Baylor College of Medicine, Houston Texas

ar_vol32.html FROM ARTHRITIS AND RHEUMATISM VOL. 32

PG. 578 1989 B172

ar_vol33.html ARTHRITIS AND RHEUMATISM VOL. 33 PG.

5156 1990 " SILICONE-ASSOCIATED CONNECTIVE TISSUE

DISEASE (CTD) FOLLOWING MAMMOPLASTY: CLINICAL COURSE

AFTER IMPLANT REMOVAL " BY PINDARO MARTINEZ-OSUNA, LUIS

R. ESPINOZA, JOHN P. GRESH, MITCHEL SELEZNICK, BERNARD

GERMAIN, FRANK B. VASEY. UNIVERSITY OF SOUTH FLORIDA,

TAMPA, FL 33612.

auto_imm.html MEDICAL DEVICE INTERACTIONS WITH THE

IMMUNE SYSTEM Immunological Effects of Silicone

bacterial_growth_in_saline_impla.htm Bacterial

growth in saline implants: in vitro and in vivo

studies. Chen NT; PE; Hooper DC; Ann Plast

Surg Date of Pub: 1996 Apr Issue/Part/Supplement: 4

Volume Issue:36 Pagination: 337-41

bi_fail.html Failure properties of 352 explanted

silicone-gel breast implants The Canadian Journal of

Plastic Surgery Walter s PhD MD FRCSC, Dennis

PhD DSc FRCS, Stanley Lugowski MSc Division of

Plastic Surgery and the Centre for Biomaterials,

Wellesley Hospital and the University of Toronto,

Toronto, Ontario

blood_wk.html Peripheral blood eosinophilia,

hyperimmunoglobulinemia A and fatigue: possible

complications following rupture of silicone breast

implants L. Schnur, M.D., Weinzweig,

M.D., B. , M.D., P.Moyer, Ph.D.,

M. Petty, M.D., Nixon, Ph.D., and ph P.

McConnell,Ph.D. ls of Allergy, Asthma & Immunology

August 1996

breast.htm Ann Plast Surg 1998 Apr;40(4):360-363

Breast reconstruction in previously irradiated

patients using tissue expanders and implants: a

potentially unfavorable result. Forman DL, Chiu J,

Restifo RJ, Ward BA, Haffty B, Ariyan S Section of

Plastic Surgery, Yale University School of Medicine,

New Haven, CT, USA.

breast.html BREAST IMPLANTS AND AUTOIMMUNE DISEASE A

new study strengthens the link between silicone gel

breast implants and autoimmune diseases such as

systemic lupus erythematosus, rheumatoid arthritis,

and a skin-hardening disorder known as scleroderma.

breast1.htm Plast Reconstr Surg 1998

Apr;101(4):1085-1088 Breast capsule persistence after

breast implant removal. Rockwell WB, Casey HD, Cheng

CA

breast2.htm Rev Med Interne 1997;18(12):955-966

[breast prostheses and their complications]. Wattiaux

MJ Service de medecine interne, hopital Saint-Antoine,

Paris, France.

case_report_toxic_shock_syndrome.htm Case Report

Toxic Shock Syndrome as a Complication of Breast

Prostheses Ann. Plast. Surg. Vol. 96, No. 7 1706 1995

The ability of bacteria to traverse the membrane

elastomer appears to hold the key to understanding

this pathologic process. The permeability of silicone

(saline) implants to substances or organisms occurs by

means of two proposed mechanisms. Either a substance

can diffuse directly though the membrane elastomer (as

with ether, lidocaine, iodine, steroids, and certain

antibiotics) or it must leak though holes in the

membrane or fill ports.

case2.html CASE REPORT SYSTEMIC INFLAMMATORY DISORDER

RELATED TO FIBROUS BREAST CAPSULES AFTER SILICONE

IMPLANT REMOVAL Copeland, DMD., MD., Aron

Kressel, MD., Harry Spiera, MD., Hermann, MD.,

and Ira J. Bleiweiss, MD. New York, NY

celdeath.html Cell Suicide in Health and Disease

Cells can--and often do--kill themselves, in a process

known as apoptosis.This capacity is essential to the

proper functioning of the body; flawed regulation may

lie behind many diseases by C. Duke, M.

Ojcius and Ding-E Young

children.html CHILDREN BREASTFED BY WOMEN WITH BREAST

IMPLANTS FDA is receiving inquiries about a

preliminary study reported in the Jan. 19 Journal of

the American Medical Association suggesting that

breastfed children of women with silicone gel breast

implants may be at risk of developing abnormal

esophageal motility.

clamen01.html Antinuclear Antibodies in Apparently

Healthy Women with Breast Implants Immunology of

Silicones, Vol 210, pp 265-268 (Jan 1996) HN Claman,

MD, AD on, PhD University of Colorado Health

Sciences Center Denver, CO USA

clinical_status_changes_in_sympt.htm Clinical Status

Changes in Symptomatic Women Exchanging Saline for Gel

Breast Implants by Vasey,MD, Noreen M. Aziz,MD,

M.P.H., Joanne Valeriano, MD, Division of

Rheumatology, University of South FL College of

Medicine and Haley VAH, Tampa, FL. We conclude

that the majority of women exchanging saline for

gelimplants did not manifest a significant improvement

in their clinical status and 50% actually demonstrated

a deterioration. While data are preliminary, we

currently recommend that symptomatic women who remove

their gel filled breast implants not replace them with

those that are saline filled.

clamen02.html Claman HN, on AD; Antinuclear

antibodies and breast implants. West J Med 1994;

160:225-228) Antinuclear Antibodies and Breast

Implants Henry N. Claman, MD, and Alastair D.

on, PhD, Denver, Colorado Based on a paper

presented at the annual meeting of the Western

Association of Physicians, Carmel, California,

February 1993.

Cosmetic Case Report Simaplast Inflatable Breast

Implants:Evaluation after 23 Years in Situ Walter

s, Ph.D., M.D., Dennis , Ph.D., D.Sc.,

Stanley Lugowski, M.Sc., Ph.D., and Pritzker,

M.D.Toronto CanadaFrom the Division of Plastic

Surgery, the Centre for Biomaterials, and the

Department of Pathology University of Toronto and

Mount Sinai Hospital. Received for Publication

February 18, 1999.

Spontaneous autoinflation of breast implants is also

rare. This phenomenon was initially reported in 1994

by Botti and coworkers. They described nine patients

with textured double-lumen implants who under went a

significant volume increase in their outer lumens, 2

to 18 months after implant insertion. Signorini and

colleagues described a similar phenomenon in three

patients with double-lumen implants, 11 which had been

in place for 2 to 7 months. The autoinflation was

unilateral in two patients and bilateral in one

patient. An all cases, the outer lumen had inflated

with a yellow to red-brown solution, which contained

cellular debris. Three of the implants bad been in

place for 7 months and contained isotonic levels of

sodium and chloride. Two other implants had been in

place for 2 months and contained hypertonic levels of

sodium and chloride

cook01.html JAMA Abstracts - May 28, 1997

Characteristics of Women With and Without Breast

Augmentation S. Cook, PhD; Janet R. Daling, PhD;

Lynda F. Voigt, PhD; M. deHart, ScD; Kathleen

E. Malone, PhD; Janet L. Stanford, PhD; Noel S. Weiss,

MD, DrPH; Louise A. Brinton, PhD; Marilie D. Gammon,

PhD; Donna Brogan, PhD (Shows what money can buy and

who putting out trash science)

Cyclosiloxanes Produce Fatal Liver and Lung Damage in

Mice Environmental Health Perspectives Volume 107,

Number 2, February 1999 [cyclosiloxanes (CSs), the

predominant low molecular weight cyclic silicones

found in breast implants] [These mice developed

inflammatory lesions of the lung and liver as well as

liver cell necrosis with elevated serum levels of

alanine aminotransferase, aspartate aminotransferase,

and lactic acid dehydrogenase. Administration of CS-D4

alone also produced lethality in these mice]

distribution_of_organosilicon_po.htm Distribution of

Organosilicon Polymers in Augmentation Mammaplasties

At Autopsy Jeffery J. Barnard, MD; L. Todd,

Ph.D.; Wesley G. , MD; Ron Mielcareck, MS, and

Rod J. Rohrich, MD. Dallas Tx and Paradise Valley, AZ

Plastic and Reconstructive Surgery, Vol 100, No. 1,

July 1997

drblais.html Dr.Pierre Blais has written an article

on saline and double lumen implants which looks at

their risks and long term safety implications

drstudy.html Dr. Nalm-Was one of the first to show

that silicone is a potent adjuvant, presented a study

on arthritis induced in rats. The silicone gel taken

from a commercial breast implant is capable of

mediating a collagen(protein in connective

tissue)induced arthritis in the rats.

effects_of_capsular_contracture_.htm Effects of

capsular contracture on ultrasonic screening for

silicone gel breast implant rupture. Medot M; Landis

GH; McGregor CE; Gutowski KA; Foshager MC; Griffiths

HJ; Cunningham BL Department of Surgery, University

of Minnesota Medical School, Minneapolis, USA. Ann

Plast Surg, 39:337-41, 1997 Oct Ultrasound should be

considered reliable in diagnosing SBI rupture only in

the absence of a contracted capsule.

entrezme.html Plast Reconstr Surg 1997

Jul;100(1):182-196 Microbial growth inside

saline-filled breast implants. Young VL, Hertl MC,

Murray PR, Jensen J, Witt H, Schorr MW Division of

Plastic and Reconstructive Surgery, Washington

University School of Medicine, St. Louis, MO., USA.

events_in_the_history_of_silicon.htm Events in the

History of Silicone Immunopathology Science & Medicine

Sept/Oct 1996

fda_stdy.html FDA SEEKING REFERRAL OF PATIENTS WHO

HAVE DEVELOPED MONOCLONAL GAMMOPATHY OR MYELOMA AFTER

SILICONE IMPLANTS OR INJECTIONS.

fdastudy.html Dr. Epstein needs information on

women who have been diagnosed with MULTIPLE MYELOMA

(also called Plasma Cell Myeloma) or MONOCLONAL

GAMMOPATHY (MGUS) (also called Plasma Cell Dyscrasias

(PCD's)