Guest guest Posted May 2, 2005 Report Share Posted May 2, 2005 COLLAGEN DISEASES Many diseases are caused by collagen deficiency or are caused by deficiencies that also cause collagen deficiency. On this page I am collecting studies related to collagen. The following study suggests that the amino acid lysine is essential for collagen production. Ciba Found Symp 1980;79:163-82 Copper and the synthesis of elastin and collagen. ED, Rayton JK, Balthrop JE, DiSilvestro RA, -de-Quevedo M. Copper's role in connective tissue is linked to the enzyme lysyl oxidase. From a biochemical perspective, copper is a cofactor for the enzyme and a determinant of its activity in connective tissues. Lysyl oxidase catalyses a post-translational oxidation of certain lysine and hydroxylysine residues. The peptidyl aldehydes so formed become active centres for the formation of cross-links in collagen and elastin. Less well understood is how copper controls the steady-state activity of lysyl oxidase; the enzyme fails in copper deficiency. Giving copper to a deprived animal increases lysyl oxidase activity in aortic tissue. Such activation in vivo appears to require caeruloplasmin. Suspending aortic tissue in a copper-enriched growth medium also activates lysyl oxidase provided that tissue structure is kept intact. Activation in vitro occurs with the binding of copper to a large-molecular-weight component, presumably the enzyme. Binding will not occur if protein synthesis is blocked. These studies clearly show that the synthesis of mature elastin and collagen can be controlled by the availability of copper. They further suggest that transport of copper to aortic tissue and its engagement to lysyl oxidase are linked to the synthesis or lysyl oxidase, an extracellular carrier, or both. PMID: 6110524 [PubMed - indexed for MEDLINE] Collagen diseases .... Many diseases are caused by collagen deficiency or are caused by deficiencies that also cause collagen deficiency. On this page I am collecting studies ... http://www.ithyroid.com/collagen_diseases.htm - 30k - similar pages - add to favorites MedlinePlus Medical Encyclopedia: Rheumatoid-collagen disease .... Rheumatoid-collagen disease is any disorder affecting the connective tissue, with " rheumatic " symptoms including muscle stiffness, soreness and pain in ... http://www.nlm.nih.gov/medlineplus/ency/article/001226.htm - 17k - similar pages - add to favorites AllRefer Health - Rheumatoid-Collagen Disease Rheumatoid-Collagen Disease information center. ... Rheumatoid-collagen disease is any disorder affecting the connective tissue, with " rheumatic " symptoms ... http://health.allrefer.com/health/rheumatoid-collagen-disease-info.html - 32k - similar pages - add to favorites Collagen disease - Medical Dictionary definitions of popular ... Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=11124 - 30k - similar pages - add to favorites Collagen Diseases - Unified Search Environment .... the term " collagen diseases " now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects ... http://www.use.hcn.com.au/subject.%60Collagen%20Diseases%60/home.html - 15k - similar pages - add to favorites Dr. Koop - Rheumatoid-collagen disease Rheumatoid-collagen disease is any disorder affecting the connective tissue, with " rheumatic " symptoms including muscle stiffness, soreness and and ... http://www.drkoop.com/ency/93/001226.html - 35k - similar pages - add to favorites Collagen Diseases .... if a gene instability (chromosome 7 inversion) exist in Gulf War veterans and other groups who exhibit symptoms of autoimmune or collagen disease. ... http://deploymentlink.osd.mil/deploymed/ImmuneBloodSystem/CollagenDiseases/Colla\ genDiseases_home.shtml - 20k - similar pages - add to favorites Penn State Faculty Research Expertise Database (FRED) .... Collagen Diseases. Description, Historically, a heterogeneous group of ... the term " collagen diseases " now pertains exclusively to those inherited ... http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D003095 - 11k - similar pages - add to favorites National Cancer Institute - Dictionary of Cancer Terms .... but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue. ... http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=44127 - 28k - similar pages - add to favorites Rheumatoid-collagen disease Rheumatoid-collagen disease. Definition:. Any disorder affecting the collagen (connective tissue), with " rheumatic " symptoms including muscle stiffness, ... http://www.virginiahospitalcenter.com/ency/article/001226.htm - Quote Link to comment Share on other sites More sharing options...
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