Guest guest Posted December 8, 2004 Report Share Posted December 8, 2004 Emmet, lithium is renally excreted not metabolised by hepatic microsomal enzymes. so there are no pharmacokinetic interactions between SJW and Li salts, (assuming that tubular p-glycoprotein does not affect renal Li re-absorption) there are no reports of pharmacodynamic interactions either nasty stuff though lithium. jonathan > > Dear Sabine, > > SJW is contraindicated with lithium . It speeds up its mtabolism in > liver, > and lowers lithium serum levels , with resultant deliterious > consequences > for pt. stability. Only herbs that do not significantly alter CYP Liver > enzyme profiles are safe to use with Lithium. > > Emmett Walsh > > > > lithium > > >> >> Can anybody tell me which herbs i should avoid for a patient on >> Lithium? >> Is SJW okay to give? Couldn't find any mention of interactions. >> Many thanks! >> Sabine >> >> >> Sabine Hiller BSc(Hons) MIIMH MNIMH >> Medical Herbalist >> Knockrooskey >> Westport >> Co.Mayo >> Tel. 098-35909 >> herbalist@... >> >> >> >> >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2004 Report Share Posted December 8, 2004 Thanks everybody for their replies! So if it is excreted renally, are there any herbs i should avoid, ? This patient wants help for cough/poss. early asthma, with plan to stop smoking in the future plus some NS and GIT support etc Planned Rx : Scut & , Achillea, Inula, Verbascum, Thymus, Cinnamon. (later SJW and Avena for smoking cessation) She is already taking Milkthistle OTC. Are any of these problematic with Lithium? What about Gingko? What's story with coming of Lithium? My patient would like to come off it somewhere in the future. Has anybody successfully replaced Lithium with herbs, or is this unrealistic? Many thanks! Sabine Re: lithium > > > Emmet, > > lithium is renally excreted not metabolised by hepatic microsomal > enzymes. > so there are no pharmacokinetic interactions between SJW and Li salts, > (assuming that > tubular p-glycoprotein does not affect renal Li re-absorption) > > there are no reports of pharmacodynamic interactions either > > nasty stuff though lithium. > > jonathan > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 8, 2004 Report Share Posted December 8, 2004 > > Thanks everybody for their replies! > > So if it is excreted renally, are there any herbs i should avoid, > ? > This patient wants help for cough/poss. early asthma, with plan to stop > smoking in the future plus some NS and GIT support etc Planned Rx : > Scut & , Achillea, Inula, Verbascum, Thymus, Cinnamon. (later SJW > and > Avena for smoking cessation) She is already taking Milkthistle OTC. > Are any > of these problematic with Lithium? What about Gingko? > conventional drug interactions wisdom is to be careful using diuretics and electrolyte balance with lithium because of the narrow TI and renal excretion. if in doubt at all, introduce extra serum monitoring of Li levels would be appropriate ..and the foolproof way to check if a herbal rx is going to affect things since these folk have to be monitored anyway for drug levels. i would definitely use renal protective herbs because of the nephrotoxicity. that would be a yes for ginkgo among others. you cannot really " substitute " herbs for lithium. i have some experience with its periodic table close relative cadmium, truly one of the most toxic chemotherapies known. these are toxic agents , Li probably works by causing brain damage - literally. getting off lithium is a laudable idea but for several reasons IMO needs a collaborative approach with someone clincially specialized in the psych drug field though. perhaps melissa could help here. i would use the orthomolecular psych resources to build the nutritional herbal program. sorry to be brief, its a large and fascinating subject, not without pitfalls. jonathan > What's story with coming of Lithium? My patient would like to come > off it > somewhere in the future. Has anybody successfully replaced Lithium > with > herbs, or is this unrealistic? > > Many thanks! > Sabine > > Re: lithium > > >> >> >> Emmet, >> >> lithium is renally excreted not metabolised by hepatic microsomal >> enzymes. >> so there are no pharmacokinetic interactions between SJW and Li salts, >> (assuming that >> tubular p-glycoprotein does not affect renal Li re-absorption) >> >> there are no reports of pharmacodynamic interactions either >> >> nasty stuff though lithium. >> >> jonathan >> > > > > > List Owner > > > > Graham White, MNIMH > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Re: lithium 1.. Undermethylation: This condition is innate & is characterized by low > levels of serotonin, dopamine, and norepinephrine, high whole blood > histamine and elevated absolute basophils. This population has a high > incidence of seasonal allergies, OCD tendencies, perfectionism, high > libido, > sparse body hair, and several other characteristics. They usually respond > well to methionine, SAMe, calcium, magnesium, omega-3 essential oils (DHA > & > EPA), B-6, inositol, and vitamins A, C, and E. They should avoid > supplements > containing folic acid. Why avoid folic acid? I thought this was needed as the methyl donor for the methylation cycle. Charlotte Charlotte Stedman MSc MNIMH Medical Herbalist & Nutritionist North London Mobile: 07973 831 205 e-mail: charlotte.stedman2@... Quote Link to comment Share on other sites More sharing options...
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