Exefor and Finasteride - VERY high prolactin

[Guest guest]

Hello, I'm new here.

I'm now 28 and I started using Efexor(Venlafaxine) 37,5mg and Finasteride 1mg at

the same time. Once I stopped using Efexor after 1,5 years of use, I continued

taking Finasteride for another year. For those who don't know, Finasteride is an

antiandrogenic drug used for Androgenetic Alopecia. I had many side effects, and

althought I suspected Efexor for some of them and considered them to be

transitory, I never suspected Finasteride could give massive side effects. For

info on post finasteride syndrome go on Propeciahelp.com.

Then I had gynecomastia, stopped finasteride, made some research and the world

collapsed on me. I was so damn lucky to take together TWO drugs known for having

serious side effects persisting after suspension. Ok, now, I do not know what

the hell went on whilst on the drugs, but my exams now report the following,

after 6 months after the suspension(on february) of Finasteride.

--30 July--

Prolactin 87 ng/ml (2-18)

FSH 1,5 mUI/ml (1,3-13,6)

17-beta-estradiol 15 pg/ml (11-44)

LH 1,4 mIU/ml (1,1-8,7)

Testosterone 3,57 ng/ml (2,80-11)

--11 August--

Prolactin(11 August)

0' --> 67,7 ng/ml (2-18)

30' --> 73,5 ng/ml (2-18)

IGF-1 148 ng/ml (119-476)

ACTH 12 ng/ml (5-77)

NMR shown no prolactinoma.

Anyone ended up with similar prolactin levels?

[Guest guest]

To: SSRIsex Sent: Wednesday, August 22, 2012 10:44 PM Subject: Exefor and Finasteride - VERY high prolactinHi,It has been shown that stress can significantly raise prolactin levels. I have my prolactin checked three times and it was high, but when I

have it checked the fourth time it was normal.

Hello, I'm new here.

I'm now 28 and I started using Efexor(Venlafaxine) 37,5mg and Finasteride 1mg at the same time. Once I stopped using Efexor after 1,5 years of use, I continued taking Finasteride for another year. For those who don't know, Finasteride is an antiandrogenic drug used for Androgenetic Alopecia. I had many side effects, and althought I suspected Efexor for some of them and considered them to be transitory, I never suspected Finasteride could give massive side effects. For info on post finasteride syndrome go on Propeciahelp.com.

Then I had gynecomastia, stopped finasteride, made some research and the world collapsed on me. I was so damn lucky to take together TWO drugs known for having serious side effects persisting after suspension. Ok, now, I do not know what the hell went on whilst on the drugs, but my exams now report the following, after 6 months after the suspension(on february) of Finasteride.

--30 July--

Prolactin 87 ng/ml (2-18)

FSH 1,5 mUI/ml (1,3-13,6)

17-beta-estradiol 15 pg/ml (11-44)

LH 1,4 mIU/ml (1,1-8,7)

Testosterone 3,57 ng/ml (2,80-11)

--11 August--

Prolactin(11 August)

0' --> 67,7 ng/ml (2-18)

30' --> 73,5 ng/ml (2-18)

IGF-1 148 ng/ml (119-476)

ACTH 12 ng/ml (5-77)

NMR shown no prolactinoma.

Anyone ended up with similar prolactin levels?

[Guest guest]

My endocrinologist said similar levels of prolactin are not due to

stress...however, considering that while I was on Finasteride I experienced

EXTREEEME anxiety (surely due to the drug) and I learnt to fight it, I can

suppose prolactin levels may have been raised as a response to this acute

effect. Were your levels similarly high? also consider I am a man, and for my

understanding, prolactin isn't that voulble in men, whilst in woman it is much

more prone to fluctuations.

PS if someone is interested on mechanisms of action, I have to say that while on

both Finasteride and Efexor, my impression is that these two drugs compensate

one with each other in some aspects of side effects. Once I stopped efexor

everything got worse: I had also a tremendous rash, gynecomastia, and many other

problems.

[Guest guest]

I have high prolactin too. but Ive read someone mentioning you shouldnt

masturbate or have sex within 24-48 hrs before test. i remember when I was on

zoloft, I had a severe nipple pain. My endo said it unknown type. He prescirbed

me dostinex but so far it only makes me sleepy but not that really horny.

I found this file on my computer, I think i got from this group site.

Antidepressants and Sexual Function

dr.s.MD

There are several types of anti-depression drugs. Widely used are

SSRIs(Selective serotonin reuptake inhibitors) and

SNRIs(Serotonin-norepinephrine reuptake inhibitor). Usually anti-depression

drugs cause excessive chronic prolactin production, this condition is called

Hyperprolactinemia (smtms. miswritten hyperprolactimia) and can best be

described as a functional disorder. Excessive prolactin in the bloodstream

reduces the testosterone and DHT release from the testicles, thus resulting in

bone and muscle weakness.

Additional function of the SSRIs is to block the dopamine nervous function in

the hypothalamus-pituitary axis, which is responsible for the release of

oxytocin (which is known as the emotional and orgasm hormone). The drugs also

tend to indirectly interfere with all the neurotransmitter systems and the

production of various hormones (usually by overloading the liver P45

detoxification system). They also block the spinal nervous transmissions in the

synapses with a flooding of serotonin (due to the re uptaking inhabitation

action). The gene expressions of D2 dopamine receptors, acetylcholine receptors

and 5-HT (Serotonin) 2C receptors are also being alternated.

SSRIs will destroy the pituitary and liver functions, thus killing your proper

sexual function. SSRIs only inhibit the re-uptaking of serotonin, but actually

the natural levels of serotonin decrease due to the destruction effects on the

liver P450. SSRIs drugs will most probably reduce the serotonin nervous action

in the neuromuscular ending receptors all over the body.

Usually the blocking of dopamine and acetylcholine transduction accompanied with

the high level prolactin, which is being dumpled into the bloodstream, disables

the nervous function in the penis, disables the seminal production, and if taken

systematically can completely desensitize the penile nerves, prostate and

seminal vesicles. Furthermore SSRIs drugs tend to block hypothalamic/adrenal -

dopamine-norepinephrine conversion and oxytocin release (essential to activation

of the orgasmic contraction). All this means that there is a high chance that

you will never achieve proper orgasm.

SSRIs anti-depression drugs cause neuroplasticity, which is a term for a

deformation of synapses and outgrowth of serotonin neurons. This neuroplasticity

is known to cause addiction and severe withdrawal symptoms. The SSRIs inhibit

the reputaking of serotonin in the nervous synapse by blocking the serotonin

transporter, thus allowing the serotonin neurotransmitter to continue

influencing the postsynaptic neurons. However we may clearly understand that

SSRIs are not increasing neurotransmitter synthesis, on the contrary - they are

cutting down natural serotonin release from the nervous terminals, it is just

that SSRIs stimulate more serotonin neurons. SSRIs antidepressants also tend to

alter the relationship between dopamine and serotonin signaling in the striatum,

which will receive moderate serotonergic and rich dopaminergic innervation. This

can be extremely harmful and may cause irreversible damage, because due to the

inhibition of serotonin transporters, the dense striatal Dopamine Transporters

can uptake serotonin into the dopamine terminals, which will destroy the

dopamine nervous function responsible for the release of oxytocin, LH and

FSH(all of the assosiated with testicular functions). Also a weak dopamine

function will result in a high pituitary release of prolactin and disable sexual

function completely.

To negate the ill effects SSRIs may cause, one must power his dopamine,

cholinergic, serotonin and GABA nervous function. The dopamine is essential to

the hypothalamus-pituiatry-testicular function.

>

>

> My endocrinologist said similar levels of prolactin are not due to

stress...however, considering that while I was on Finasteride I experienced

EXTREEEME anxiety (surely due to the drug) and I learnt to fight it, I can

suppose prolactin levels may have been raised as a response to this acute

effect. Were your levels similarly high? also consider I am a man, and for my

understanding, prolactin isn't that voulble in men, whilst in woman it is much

more prone to fluctuations.

>

>

> PS if someone is interested on mechanisms of action, I have to say that while

on both Finasteride and Efexor, my impression is that these two drugs compensate

one with each other in some aspects of side effects. Once I stopped efexor

everything got worse: I had also a tremendous rash, gynecomastia, and many other

problems.

>