Guest guest Posted March 17, 2001 Report Share Posted March 17, 2001 , I am not familiar with either of these materials or any reports of antimicrobial efficacy for them. Young KY Labs Innovators of Fine Personal Care Products www.kylabs.com Natural Preservatives Aromatic Greetings Everyone, Well I am back! I have been off for a while, as I have relocated Canadian Institute of Aromatherapy as well we have our 3rd successfull Aromatherapy Seminar/Tour taking place in Lebanon presently. I have a few questions for both Maurice and , if you please: What percentage of both Hydrozimtalcohol and Heliotropin are recommended for use in skin care products? Are there any clinical studies to support the efficiency of these products in controlling the growth of bacterii? May all your steps be scented, Al Takach, Dip AT, Principal & Founder Canadian Institute of Aromatherapy 5616 Emerald Avenue, Unit #26 Montreal, Quebec H4W 2S8 Canada Tel: Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 17, 2001 Report Share Posted March 17, 2001 Aromatic Greetings Everyone, Well I am back! I have been off for a while, as I have relocated Canadian Institute of Aromatherapy as well we have our 3rd successfull Aromatherapy Seminar/Tour taking place in Lebanon presently. I have a few questions for both Maurice and , if you please: What percentage of both Hydrozimtalcohol and Heliotropin are recommended for use in skin care products? Are there any clinical studies to support the efficiency of these products in controlling the growth of bacterii? May all your steps be scented, Al Takach, Dip AT, Principal & Founder Canadian Institute of Aromatherapy 5616 Emerald Avenue, Unit #26 Montreal, Quebec H4W 2S8 Canada Tel: Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 18, 2001 Report Share Posted March 18, 2001 On Sat, 17 Mar 2001 09:08:44 -0800, canadian institute of aromatherapy wrote: >What percentage of both Hydrozimtalcohol and Heliotropin are recommended for use in skin care products? I've heard of Heliotropin (INCI name: Heliotropine) before but it was in reference to fragrance creation or developement. The CAS number for Heliotropin, also called Piperonal, is 120-57-0. I did do a web search and found one reference to the use of Hydrozimtalcohol and Heliotropin as a preservative on the Aroma Shoppe website <http://www.aromashoppe.com/supply.html>. This website also lists Grapefruit Seed Extract as a natural preservative. So you can be the judge on the accuracy posted on that website. I'm always skeptical of technical information that may be biased by the need for economic gain. >Are there any clinical studies to support the efficiency of these products in controlling the growth of bacterii? I did try a MEDLINE search for for " Hydrozimtalcohol " and found nothing. Does it have another name? Listed below are the selected results of my MEDLINE search or " heliotropin or piperonal " . _________________ Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. Anto RJ, J, Babu KV, Rajasekharan KN, Kuttan R. Mutat Res. 1996 Sep 13;370(2):127-31. Amala Cancer Research Center, Kerala, India. Five synthetic curcuminoids and three natural curcuminoids were investigated for their antimutagenic and anti-promotional activity. The natural curcuminoids, curcumin I (diferuloylmethane), curcumin II (feruloyl-p-hydroxycinnamoylmethane) and curcumin III (bis-(p-hydroxycinnamoyl)methane) isolated from Curcuma longa were found to be potent inhibitors of mutagenesis and crotean oil-induced tumour promotion. Curcumin III produced 87.6% inhibition to 2-acetamidofluorene (2-AAF) induced mutagenesis, at a concentration of 100 micrograms/plate, curcumin II and curcumin I produced 70.5% and 68.3% inhibition at the same concentration. All the synthetic curcuminoids were found to inhibit 2-AAF-induced mutagenicity among which salicyl- and anisylcurcuminoids were the most active. Curcumin III was the most effective anti-promotor among natural curcuminoids. While 90% of the control animals were having papillomas on the 10th week of tumour initiation, only 10% of the curcumin III-treated animals, 20% of the curcumin II-treated animals, and 40% of the curcumin I-treated animals were having papillomas. Salicylcurcuminoid, which was causing no papillomas by the 10th week, was the most potent anti-carcinogen among the synthetic curcuminoids. Piperonal curcuminoid also exhibited anti-promotional activity. _________________ Fragrance administration to reduce anxiety during MR imaging. Redd WH, Manne SL, s B, sen PB, Schmidt H. J Magn Reson Imaging. 1994 Jul-Aug;4(4):623-6. Psychiatry Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021. Fifty-seven outpatients received either heliotropin (a vanillalike scent) with humidified air (n = 20) or humidified air alone (n = 37) via a nasal cannula during magnetic resonance imaging in the diagnostic workup for cancer. Delivery of heliotropin and air was determined by a computer-controlled schedule. Fragrance administration resulted in a statistically significant reduction in average overall patient-rated anxiety (on a visual analog scale) during imaging in patients who found the fragrance moderately to extremely pleasant. Administration of fragrance was associated with 63% less anxiety than administration of humidified air alone. Physiologic measures (pulse and heart rate) did not show a statistically significant effect with fragrance administration. _________________ Arena tests with piperonal, a new louse repellent. Peock S, Maunder JW. J R Soc Health. 1993 Dec;113(6):292-4. Comment in: J R Soc Health. 1994 Apr;114(2):108 Medical Entomology Centre, University of Cambridge, Fulbourn. Piperonal, once used to kill lice in Australian hospitals, was acclaimed as an effective pediculicide (Corlette, 1925) by the standards of the day. It is unusual in also exhibiting a repellent action against lice, a property only recently realised. A new, easy to use, low-fragrance, pump action spray, which incorporates 2% piperonal, was tested in the laboratory using clothing lice in an arena test and was found to exhibit consistently high repellency after half an hour, dropping only slightly after 24 hours. A well known multi-purpose insect repellent, diethyltoluamide (DEET), was then tested against piperonal. A 2% solution of piperonal was found to be almost twice as effective as a 50% solution of DEET. In arena tests using lice with the tip segments of both antennae removed, no behavioural differences or statistically significant differences from a random distribution could be found between untreated and Rappell-treated areas. This strongly suggests that sense organ(s) on the tip of the antenna are necessary for detection of the repellent. Although there can be no strict correlation between results in the laboratory and potential efficacy in the field, materials such as insecticides found to be effective in the laboratory have been found to be equally effective in the field. Furthermore, what with the threat of resistance to head lice insecticides, ineffectual treatment and the lack of contact tracing, a repellent would be of obvious use in the control of head lice. _________________ Metabolic disposition of piperine in the rat. Bhat BG, Chandrasekhara N. Toxicology. 1987 Apr;44(1):99-106. After oral administration of piperine (170 mg/kg) to rats, the metabolites in bile and urine were examined by thin-layer chromatography, high-performance liquid chromatography and combined gas chromatography-mass spectrometry. Four metabolites of piperine, viz. piperonylic acid, piperonyl alcohol, piperonal and vanillic acid were identified in the free form in 0-96 h urine whereas only piperic acid was detected in 0-6 h bile. Based on these results, a pathway for the biotransformation of piperine in rats is proposed. Maurice ------------------------ Maurice O. Hevey Convergent Cosmetics, Inc. http://www.ConvergentCosmetics.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 18, 2001 Report Share Posted March 18, 2001 >I've heard of Heliotropin (INCI name: Heliotropine) before but it was in reference to fragrance creation or developement. The CAS number for Heliotropin, also called Piperonal, is 120-57-0. I did do a web search and found one reference to the use of Hydrozimtalcohol and Heliotropin as a preservative on the Aroma Shoppe website <http://www.aromashoppe.com/supply.html>. This website also lists Grapefruit Seed Extract as a natural preservative. Marurice- >So you can be the judge on the accuracy posted on that website. I'm always skeptical of technical information that may be biased by the need for economic gain. The owner of Aroma Shoppe is the current President of the CFA, considering I am a member of that association I can not comment. >I did try a MEDLINE search for for " Hydrozimtalcohol " and found nothing. Does it have another name? Not to my knowledge, but it seems to be quite effective according to Aroma Shoppe. This is why I wanted to know if anyone else has experienced the effects of these two preservatives. Listed below are the selected results of my MEDLINE search or " heliotropin or piperonal " . _________________ Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. Anto RJ, J, Babu KV, Rajasekharan KN, Kuttan R. Mutat Res. 1996 Sep 13;370(2):127-31. Amala Cancer Research Center, Kerala, India. Five synthetic curcuminoids and three natural curcuminoids were investigated for their antimutagenic and anti-promotional activity. The natural curcuminoids, curcumin I (diferuloylmethane), curcumin II (feruloyl-p-hydroxycinnamoylmethane) and curcumin III (bis-(p-hydroxycinnamoyl)methane) isolated from Curcuma longa were found to be potent inhibitors of mutagenesis and crotean oil-induced tumour promotion. Curcumin III produced 87.6% inhibition to 2-acetamidofluorene (2-AAF) induced mutagenesis, at a concentration of 100 micrograms/plate, curcumin II and curcumin I produced 70.5% and 68.3% inhibition at the same concentration. All the synthetic curcuminoids were found to inhibit 2-AAF-induced mutagenicity among which salicyl- and anisylcurcuminoids were the most active. Curcumin III was the most effective anti-promotor among natural curcuminoids. While 90% of the control animals were having papillomas on the 10th week of tumour initiation, only 10% of the curcumin III-treated animals, 20% of the curcumin II-treated animals, and 40% of the curcumin I-treated animals were having papillomas. Salicylcurcuminoid, which was causing no papillomas by the 10th week, was the most potent anti-carcinogen among the synthetic curcuminoids. Piperonal curcuminoid also exhibited anti-promotional activity. _________________ Fragrance administration to reduce anxiety during MR imaging. Redd WH, Manne SL, s B, sen PB, Schmidt H. J Magn Reson Imaging. 1994 Jul-Aug;4(4):623-6. Psychiatry Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021. Fifty-seven outpatients received either heliotropin (a vanillalike scent) with humidified air (n = 20) or humidified air alone (n = 37) via a nasal cannula during magnetic resonance imaging in the diagnostic workup for cancer. Delivery of heliotropin and air was determined by a computer-controlled schedule. Fragrance administration resulted in a statistically significant reduction in average overall patient-rated anxiety (on a visual analog scale) during imaging in patients who found the fragrance moderately to extremely pleasant. Administration of fragrance was associated with 63% less anxiety than administration of humidified air alone. Physiologic measures (pulse and heart rate) did not show a statistically significant effect with fragrance administration. _________________ Arena tests with piperonal, a new louse repellent. Peock S, Maunder JW. J R Soc Health. 1993 Dec;113(6):292-4. Comment in: J R Soc Health. 1994 Apr;114(2):108 Medical Entomology Centre, University of Cambridge, Fulbourn. Piperonal, once used to kill lice in Australian hospitals, was acclaimed as an effective pediculicide (Corlette, 1925) by the standards of the day. It is unusual in also exhibiting a repellent action against lice, a property only recently realised. A new, easy to use, low-fragrance, pump action spray, which incorporates 2% piperonal, was tested in the laboratory using clothing lice in an arena test and was found to exhibit consistently high repellency after half an hour, dropping only slightly after 24 hours. A well known multi-purpose insect repellent, diethyltoluamide (DEET), was then tested against piperonal. A 2% solution of piperonal was found to be almost twice as effective as a 50% solution of DEET. In arena tests using lice with the tip segments of both antennae removed, no behavioural differences or statistically significant differences from a random distribution could be found between untreated and Rappell-treated areas. This strongly suggests that sense organ(s) on the tip of the antenna are necessary for detection of the repellent. Although there can be no strict correlation between results in the laboratory and potential efficacy in the field, materials such as insecticides found to be effective in the laboratory have been found to be equally effective in the field. Furthermore, what with the threat of resistance to head lice insecticides, ineffectual treatment and the lack of contact tracing, a repellent would be of obvious use in the control of head lice. _________________ Metabolic disposition of piperine in the rat. Bhat BG, Chandrasekhara N. Toxicology. 1987 Apr;44(1):99-106. After oral administration of piperine (170 mg/kg) to rats, the metabolites in bile and urine were examined by thin-layer chromatography, high-performance liquid chromatography and combined gas chromatography-mass spectrometry. Four metabolites of piperine, viz. piperonylic acid, piperonyl alcohol, piperonal and vanillic acid were identified in the free form in 0-96 h urine whereas only piperic acid was detected in 0-6 h bile. Based on these results, a pathway for the biotransformation of piperine in rats is proposed. Okay, thank you very much! If there is anyone with personal experience please contact me I would be very curious of your findings. Thanks again Maurice. Have a great day! Al Takach, Dip.At, Principal & Founder Canadian Institute of Aromatherapy 5616 Emerald Avenue, Suite # 26 Montreal, Quebec H4W 2S8 Canada Tel: Quote Link to comment Share on other sites More sharing options...
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