Guest guest Posted April 16, 2005 Report Share Posted April 16, 2005 http://searcht.netscape.com/ns/boomframe.jsp?query=silicone+children+lupus & page=\ 2 & offset=1 & result_url=redir%3Fsrc%3Dwebsearch%26requestId%3D8bb0e861f183c38b%26c\ lickedItemRank%3D10%26userQuery%3Dsilicone%2Bchildren%2Blupus%26clickedItemURN%3\ Dhttp%253A%252F%252Fwww.drmyhill.co.uk%252Farticle.cfm%253Fid%253D86%26invocatio\ nType%3Dnext%26fromPage%3DNSCPNextPrev%26amp%3BampTest%3D1 & remove_url=http%3A%2F\ %2Fwww.drmyhill.co.uk%2Farticle.cfm%253Fid%253D86 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2005 Report Share Posted April 16, 2005 > http://searcht.netscape.com/ns/boomframe.jsp? query=silicone+children+lupus & page=2 & offset=1 & result_url=redir%3Fsrc% 3Dwebsearch%26requestId%3D8bb0e861f183c38b%26clickedItemRank%3D10% 26userQuery%3Dsilicone%2Bchildren%2Blupus%26clickedItemURN%3Dhttp% 253A%252F%252Fwww.drmyhill.co.uk%252Farticle.cfm%253Fid%253D86% 26invocationType%3Dnext%26fromPage%3DNSCPNextPrev%26amp%3BampTest% 3D1 & remove_url=http%3A%2F%2Fwww.drmyhill.co.uk%2Farticle.cfm%253Fid% 253D86 Great link Rogene! Again, I want to post this for posterity in case this link ever goes dead... Silicone Breast Implants and Injections I have now been consulted by over 100 patients with chronic ill health following silicone breast implants or injections. Silicone leaks (so called " gel bleed " ) out of the implant where it is picked up by the reticulo-endothelial cells and distributed widely throughout the whole body. The government body responsible for licensing silicone, the Medical Devices Agency, claims that silicone is inert and does no harm despite this gel bleed. My clinical experience and the scientific literature suggests otherwise. There are many problems with implants, of which the most obvious is infection at the time of insertion. However, the long term effects are far more malign. This stems from the fact that silicone cannot be broken down by any enzyme system in the body, is engulfed by macrophages, carried to distant sites by embolisation and there it acts as an immune adjuvant, stimulating autoimmune disorders. This means that these patients suffer from multisystem autoimmune disease. In particular, clinically one sees: mixed connective tissue disease, demyelinating conditions such as MS autoimmune endocrinopathies, vasculitis, myopathies, - all of which eventually leads to a chronic fatigue syndrome often including multiple chemical sensitivity My clinical impression is that the silicone poisoned patients suffer more from pain than the virally or OP induced CFS. I have concluded from my own observations that silicone causes a new disease unique to silicone but resembling other diseases. All of these cases I have reported to the MDA. None of these cases were reported to the MDA by either their plastic surgeon or rheumatologist or oncologist. This simply reflects the level of gross under-reporting of side effects. It is well recognised that the silicone bleeds out of the implants very readily and is widely distributed throughout the body by the reticulo-endothelial system. Silicone leaks out as soon as the implants are put in. I know this because the Medical Devices Agency, which is the government body responsible for licensing these products, tells me so. However, where we disagree is what happens to the silicone then. The MDA maintains that it is inert, but actually silicone is well recognised as being an immune adjuvant and I suspect in susceptible individuals we get an inflammatory reaction against the silicone which results in multi-system disease. The Louisiana ruling on 19.8.97 showed that Dow Corning was developing silicone for use as an active pharmaceutical agent at the same time as when it was being declared " inert " . There is no known mechanism by which silicone can be excreted from the body. Silicone leakage is accelerated when implants rupture, of which 50% do so by 12 years and 95% by 20 years. Most of these ruptures are spontaneous but some follow closed capsulotomy, road traffic accident or whatever. A recent Lancet paper November 1997) recommends that all implants are replaced every 8 years. Silicone leakage can be a problem locally whereby the body throws up a scar capsule against the implant to try to prevent the silicone from leaking. As this scar contracts this causes local hardening of the breast, often with pain. Surgeons treat this by crushing the breast between their hands (often with no anaesthetic!) to rupture the scar capsule (this unproven, extremely painful procedure has been sanitised by giving it a name: closed capsulotomy). The implant may also be ruptured by this procedure. Once ruptured, the silicone may migrate in a lump to the axilla and brachial plexus causing pain and blockage of lymphatics, across the breast causing a mis- shapen breast (one patient had to have her nipples surgically re-sited), or down the chest wall. Generalised effects of silicone are caused by silicone migrating via the reticulo-endothelial system to the rest of the body and causing inflammatory reactions wherever silicone ends up. In the brain this causes a multiple sclerosis-like syndrome, in the body it can cause a range of autoimmune disorders, chronic fatigue syndrome, chronic pain and multiple chemical sensitivity. Tests For Silicone Poisoning Prof Garry's lab in the USA offers antibody testing. He measures the anti-polymer antibody levels. However, this is expensive and is not specific for siliconosis. So I rarely do this test nowadays. His address is Dept of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112 tel 001 504 587 2027 fax 001 504 584 1994. I can arrange the test if this is easier - I can post the kit to the patient for the blood to be taken locally and make arrangements to dispatch the sample to America via a courier. The cost is & #65436;150 for the test and & #65436;20 for the transport. I have just had an extract of silicone made up for skin testing and am getting interesting results! This test is designed to look at the body's immune response to silicone. The extract is a very dilute solution (1:100) which is injected intradermally to bring up a weal of about 7 by 7mm. Ten minutes later this is measured. A complete non-reactor would have no growth and flattening of the weal. Reactors show a growth in the size of the weal. A positive reaction supports the idea that the body is reacting positively to silicone. Again I don't know the medico-legal aspects of this test until I have done a reasonable number including controls (i.e people who have never been exposed to silicone). I don't see why it should not be possible to try a desensitisation technique called neutralisation from the test extract.For a list of practitioners, visit www.bsaenm.org The most sensitive test available in this country to assess the reaction of white cells to silicone in the body is a lymphocyte chemical sensitivity (silicone) test This just involves sending a blood sample to Biolab in London. My clinical impression of tests done so far is that the worst affected women have the highest levels of sensitivity. Treatment I have been in direct contact with Professor Radford Shanklin from the States who has been most helpful with clinical management. We had a long meeting at the Royal Society of Medicine where I could pick his brains. The priority is to have the silicone removed by a surgeon skilled in explantation. However, the problem with explantation is that it is thought to stir up a reaction against silicone and patients often see a worsening of their symptoms which may last up to 3 years. Prof. Shanklin tells me that reactions against silicone are medicated by T cells and interleukin 2. He has been trying Plaquenil 200mgs twice daily for 90 days before surgery and believes this damps down the T cell activity and prevents this post operative flare. Plaquenil is a standard immunosuppressive drug used to treat rheumatoid arthritis and systemic lupus erythematosis. It is a fairly benign drug and it is felt that for short term treatment no special monitoring is required although it is probably medically prudetn to check a white cell count and eye test before and during treatment. Explantation needs to be done by a skilled surgeon aware of the need not to rupture the capsule inadvertently. Furthermore, the scar capsule also needs removing because it will be impregnated with silicone. Insist on being given the implant after surgery and don't allow the surgeon to make up an excuse. I had one patient who was told the implant was removed intact, but it was " scrubbed " to make it look better and ruptured in that process, therefore it was not available to be seen! Let's face it - you've paid for it - it belongs to ysu! The CFS side of things I treat in exactly the same way as I treat all my other CFS patients with fatigue caused by viral infection or pesticide poisoning or whatever. Namely rest, nutritional supplements, elimination dieting, magnesium injections where appropriate (blood test needed), B12 injections, avoiding chemicals, etc. Second Generation Effects There is every reason to expect silicone to cross the placenta into the unborn child. The effects of this are uncertain. Prof Shanklin has looked at a group of 190 women who had babies before and after their implant. There were 127 pre-implant children of which 100 were in good health, 27 in fair health (minor transient problems) and none sick. This compares to 252 post-implant children, of which 78 were in good health 81 in fair health with 93 WHO WERE MORE SERIOUSLY ILL (compares to none in the pre-implant group!). This experience certainly accords with what I am seeing in my patients. However, I would like to repeat this research in all my patients and hope to attract some modest funds to allow me to do this. I would do it myself if I had the time, but I don't. I would need to employ somebody short term to contact women. Any volunteers? See also: Neutralisation in FOOD ALLERGY section Related Test Lymphocyte Sensitivity to Silicone Related articles CFS Checklist - start off and check your treatment regime here « BACK --------------------------------------------------------------------- ----------- Myhill Limited :: Registered in England and Wales :: Registration No. 4545198 Registered Office: Upper Weston, Llangunllo, Knighton, Powys, Wales LD7 1SL, UK. Tel 01547 550331 | Fax 01547 550339 | E-mail info@... onlineWales Internet Ltd ©2001-2003 Article No. 86 Quote Link to comment Share on other sites More sharing options...
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