Re: Annybody believes in 5HT1A antagonists?

[Guest guest]

Has anybody tried Lecozotan?

>

>

> Subject: Annybody believes in 5HT1A antagonists?

> To: SSRIsex

> Date: Wednesday, December 8, 2010, 3:56 PM

>

>

>

>

>

>

>

>  

>

>

>

>

>

>

>

>

>

> As I read on wikipedia

(http://en.wikipedia.org/wiki/Post-SSRI_sexual_dysfunction) ssri's downregulate

5HT1A receptors.

>

> Further research indicated that the use of 5HT1A antagonists are capable of

upregulating these receptors.

>

>

(http://eurekamag.com/research/036/007/up-regulation-5-ht1a-receptor-special-ant\

agonist-way-100635-adult-rat-hippocampus.php)

>

>

>

> With further researching I came across this medicin: Lecozotan

(http://en.wikipedia.org/wiki/Lecozotan) wich is in Phase III clinical trails)

>

>

>

> I've read this:

>

>

>

> Lecozotan is a competitive, selective 5-HT1A receptor antagonist[3] which

enhances the potassium-stimulated release of acetylcholine and glutamate.[4]

>

>

>

> This reminded me of something i've read here about glutamate and sexual

behavior.

>

> Is this a possible treatment? Will upregulation of this receptor give any

relief?

>