Migraine Drug Info

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FYI

Migraine Drug Eletriptan Absorbed Rapidly

SEVILLE, SPAIN -- Sept. 22, 1998 -- Pfizer Inc.'s eletriptan, an

antimigraine compound, is rapidly absorbed, exhibits predictable

pharmacokinetics following oral dosing and appears to be well tolerated

across age groups, according to a study reported at the third congress

of the European Federation of Neurological Societies.

Studies were conducted to evaluate the pharmacokinetics of eleptriptan

in healthy male and females from age 18 to 93 and separately in subjects

with renal and hepatic impairment.

The study was presented by Milton, clinical project manager of

Pfizer Ltd.'s central research facility in Sandwich, England.

The study found that in healthy volunteers, systemic exposure is

essentially linear over the dose range from 20 to 120 mg and that

elimination is primarily by metabolism in the liver with only 10 percent

of the dose excreted in urine.

" Gender has no effect on the pharmacokinetics of eletriptan, " Dr. Milton

said. " In the elderly some evidence was found of a small increase in

exposure on eletriptan resulting in a longer half-life in this group.

" We believe this is caused by a slower elimination rate and therefore

decreased clearance in this age group. "

In subjects with mild to moderate hepatic impairment, Dr. Milton

reported some evidence of a small increase in exposure to eletriptan,

probably related to decreased clearance and in those with mild, moderate

or sever renal impairment the study found no significant effect on the

pharmacokinetics of eletriptan.

Lyn

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