A rather amazing relationship described

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I wish I could read Japanese!

Nihon Shinkei Seishin Yakurigaku Zasshi. 2004 Apr;24(2):93-9. Related

Articles, Links

[Dysfunction of serotonergic systems in thiamine-deficient diet fed

mice: effects of SSRI on abnormality induced by thiamine deficiency]

[Article in Japanese]

Murata A, Nakagawasai O, Yamadera F, Oba A, Wakui K, Arai Y, Tadano T.

Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1

Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.

Mice fed a thiamine deficient (TD) diet, showed some abnormal

behaviors such as amnesia and mood abnormality. It is known that several

neurons, especially marked in serotonergic neuron, are damaged in humans

and rodents in the earlier phase of TD. The symptoms derived from

dysfunction of serotonergic neurons are observed in Wernicke-Korsakoff

patients (WKS)-derived TD, and it is known that fluvoxamine is effective

for WKS. However, the mechanism of this dysfunction is still unclear. For

that reason, we studied the relative mechanism between abnormal behaviors

and selective dysfunction of serotonergic neurons in TD animals. As a

result, this dysfunction by TD is much affected by the brainstem region.

But the effect of fluvoxamine on depressive symptoms in WKS patients is not

reported; therefore we also studied the effects of fluvoxamine on the

depressive behaviors in TD mice as a model of WKS. The increase of

immobility time in a forced swimming test as depressive behavior in TD mice

was significantly inhibited by fluvoxamine, suggesting an improvable effect

on depressive symptoms. With those results of ours, the possible mechanisms

between the abnormal behaviors derived from the dysfunction of serotonergic

neurons and the role of serotonin in TD and WKS are reviewed here.

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PMID: 15164618 [PubMed - indexed for MEDLINE]