why isn't this more widely known????

[Guest guest]

Mol Chem Neuropathol. 1996 May-Aug;28(1-3):77-81.

Immunogenetic studies in autism and related disorders.

Warren RP, Singh VK, Averett RE, Odell JD, Maciulis

A, Burger RA, s WW, Warren WL. Utah State

University, Logan 84322, USA.

The major histocompatibility complex comprises a

number of genes that control the function and regulation of the immune

system. One of these genes, the C4B gene, encodes a product that is involved in eliminating pathogens such as viruses and bacteria from the body.

We previously reported that a deficient form of the C4B gene, termed

the C4B null allele (no C4B protein produced) had an increased

frequently in autism. In this study we attempted to confirm the

increased incidence of the C4B null allele in autism and investigated

the presence of a C4B null allele in two other childhood disorders,

attention-deficit hyperactivity disorder and dyslexia (reading

disability). In addition, we explored the relationship of autism to the

DR beta 1 gene, a gene located close to the C4B in autism. We

confirmed the finding of an increased frequency of the C4B null allele

in autism and found that the related disorders also had an increased

frequency of this null allele. In addition, two alleles of the DR beta 1 gene also had significantly increased representation in the autistic subjects.

Publication Types: Review

PMID: 8871944 [PubMed - indexed for MEDLINE]

[Guest guest]

Do you think the DR Beta 1 gene comes from the fibromyalgia/ CFS

kind of disorders. I think my son got slammed with both kinds of

genes - the ADD one and this one. Would these sit on the methylation

cycle somewhere?

Gayatri

>

> Mol Chem Neuropathol. 1996 May-Aug;28(1-3):77-81.

>

> Immunogenetic studies in autism and related disorders.

>

> Warren RP, Singh VK, Averett RE, Odell JD, Maciulis A, Burger

RA,

> s WW, Warren WL. Utah State University, Logan 84322, USA.

>

> The major histocompatibility complex comprises a number of

genes

> that control the function and regulation of the immune system. One

of

> these genes, the C4B gene, encodes a product that is involved in

> eliminating pathogens such as viruses and bacteria from the body.

We

> previously reported that a deficient form of the C4B gene, termed

the

> C4B null allele (no C4B protein produced) had an increased

frequently in

> autism. In this study we attempted to confirm the increased

incidence of

> the C4B null allele in autism and investigated the presence of a

C4B

> null allele in two other childhood disorders, attention-deficit

> hyperactivity disorder and dyslexia (reading disability). In

addition,

> we explored the relationship of autism to the DR beta 1 gene, a

gene

> located close to the C4B in autism. We confirmed the finding of an

> increased frequency of the C4B null allele in autism and found

that the

> related disorders also had an increased frequency of this null

allele.

> In addition, two alleles of the DR beta 1 gene also had

significantly

> increased representation in the autistic subjects.

>

> Publication Types: Review

> PMID: 8871944 [PubMed - indexed for MEDLINE]

>