Re: Anyone ever have their child's Triglycerides checked?? Because...

[Guest guest]

There is a connection between triglycerides and autism.Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5;141(6):666-8. Related Articles, Links    Click here to read     Abnormalities of cholesterol metabolism in autism spectrum disorders.    Tierney E, Bukelis I, RE, Ahmed K, Aneja A, Kratz L, Kelley RI.    Kennedy Krieger Institute, Baltimore, land 21211, USA. Tierney@...    Although -Lemli-Opitz Syndrome (SLOS), a genetic condition of impaired cholesterol biosynthesis, is associated with autism [Tierney et al., 2001; Am J Med Genet 98:191-200.], the incidence of SLOS and other sterol disorders among individuals with autism spectrum disorders (ASD) is unknown. This study investigated (1) the incidence of biochemically diagnosed SLOS in blood samples from a cohort of subjects with ASD from families in which more than one individual had ASD and (2) the type and incidence of other sterol disorders in the same group. Using gas chromatography/mass spectrometry, cholesterol, and its precursor sterols were quantified in 100 samples from subjects with ASD obtained from the Autism Genetic Resource Exchange (AGRE) specimen repository. Although no sample had sterol levels consistent with SLOS, 19 samples had total cholesterol levels lower than 100 mg/dl, which is below the 5th centile for children over age 2 years. These findings suggest that, in addition to SLOS, there may be other disorders of sterol metabolism or homeostasis associated with ASD.    Publication Types:        * Research Support, N.I.H., Extramural        * Research Support, Non-U.S. Gov't    PMID: 16874769 [PubMed - indexed for MEDLINE]I'm just curious if anyone in this group has ever had their child's Triglycerides checked... I've read that some parents give their children Fenugreek for social language. I did a search on Fenugreek and read that it actually has benefical effects on Triglycerides.Interestingly enough, when my son's Doctor did a blood panel recently to check his WBC/RBCs - they forgot to do the liver function part of the lab and instead I noticed on the WBC/RBC panel it showed at the bottom my son's Triglyceride level... it was off the charts (with a normal range of 30-104 mg/dL... and his was 352 (H). I couldn't believe it - because he doesn't eat a high fat diet - he is only 4 years old and not overweight. I checked with my son's Pediatricians office and the nurse said "oh well, some people might have a genetic reason why they do and he probably gets it from someone in the family"... I left a message with his Pediatrician and I'm still waiting for her to return my call.I still don't have any answers as to WHY his triglycerides are so high and I'm not going to accept that this is just an "oh well" thing. Can anyone refer me to a good Doctor that knows anything about this? ALSO, Does anyone know if there is a connection to Triglyceride levels, viral issues, and/or autism?????????????????????????????????????Someone please kindly respond,budsmom

[Guest guest]

My

father had sky-high triglycerides, his doctor put him on medication and suggested

fish oil supps in addition to lower it and it reduced

significantly and almost immediately without him adapting any substantial

lifestyle changes (diet/exercise). His doctor said the high number and quick

reduction without his changing life style habits usually meant that it was a

genetic reason for the high ratio unlike individuals whose numbers don’t

change without adapting a better diet, etc.

Anyone ever

have their child's Triglycerides checked?? Because...

I'm just curious if anyone in this group has ever had their child's

Triglycerides checked... I've read that some parents give their

children Fenugreek for social language. I did a search on Fenugreek

and read that it actually has benefical effects on Triglycerides.

Interestingly enough, when my son's Doctor did a blood panel recently

to check his WBC/RBCs - they forgot to do the liver function part of

the lab and instead I noticed on the WBC/RBC panel it showed at the

bottom my son's Triglyceride level... it was off the charts (with a

normal range of 30-104 mg/dL... and his was 352 (H). I couldn't

believe it - because he doesn't eat a high fat diet - he is only 4

years old and not overweight. I checked with my son's Pediatricians

office and the nurse said " oh well, some people might have a genetic

reason why they do and he probably gets it from someone in the

family " ... I left a message with his Pediatrician and I'm still

waiting for her to return my call.

I still don't have any answers as to WHY his triglycerides are so

high and I'm not going to accept that this is just an " oh well "

thing. Can anyone refer me to a good Doctor that knows anything

about this? ALSO, Does anyone know if there is a connection to

Triglyceride levels, viral issues, and/or

autism?????????????????????????????????????

Someone please kindly respond,

budsmom

[Guest guest]

Not much of this is studied well yet as to what is going on with lipid/cholesterol/triglyceride derrangements in various kids.  Like all things in ASD, its a different pathway or issue from sub groups of kids to other subgroups.  I would not come to any hard conclusion on any science in any individual case with this very heterogenous situation.  I would say with regards to what the paper below is finding in PUFA, there could be abnormal handling issues that are leading to blood levels of PUFA being abnormal and other tissues could just as well have problems getting PUFA in the right spots because of Apolipoprotein problems so the lipids are accumulating in the blood and not getting into the brain?  Most kids that would be expected to be deficient for intake on PUFAs anyway so this begs the question as to why they are accumulating in the blood (can't get into the brain??).  This paper shows nice observations but I would say their conclusions are more likely wrong than right in most ASD cases (they still could actually be right in a smaller subset of kids-again many pathways into this on all kinds of biochemical levels).: Neuro Endocrinol Lett. 2006 Aug;27(4):465-71. Related Articles, Links    Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism?    Sliwinski S, Croonenberghs J, Christophe A, Deboutte D, Maes M.    University Center of Child and Adolescent Psychiatry, ZNA Middelheim, University of Antwerp, Wilrijk, Belgium. sonja.sliwinski@...    OBJECTIVES: There is now some evidence that alterations in fatty acids may play a role in the pathophysiology of autism. The aim of the present study was to examine whether autism is accompanied by abnormalities in the composition of the polyunsaturated fatty acids (PUFAs) in plasma phospholipids. METHODS: The plasma phospholipid omega-3 (3) and omega-6 (6) PUFA fractions and the 3/6 ratio were measured in 16 high-functioning male youngsters with autism (age 12-18) and 22 healthy volunteers. Group mean differences were assessed by means of analysis of variance (ANOVA). RESULTS: In autism there was a significant increase in the fraction of C22:6-3 (docosahexaenoic acid, DHA) and an increase in the total 3/6 ratio. DISCUSSION: The results of this study suggest that an increase of the plasma phospholipid 3 PUFAs, in particular DHA, and of the total 3/6 ratio may take part in the pathophysiology of autism. One hypothesis is that an increase of 3 PUFAs may cause alterations in the serotonergic turnover and the immune response system, both known to be associated with autism. Caution must be exercised against highly concentrated 3 PUFAs supplementation.    Publication Types:        * Research Support, Non-U.S. Gov't    PMID: 16891996 [PubMed - indexed for MEDLINE]1: Mol Psychiatry. 2006 Dec 26; [Epub ahead of print] Related Articles, Links    Click here to read Click here to read     A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins.    Corbett BA, Kantor AB, Schulman H, WL, Lit L, Ashwood P, Rocke DM, Sharp FR.    [1] 1Department of Psychiatry and Behavioral Sciences, University of California at , Sacramento, CA, USA [2] 2Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California at , Sacramento, CA, USA.    Modern methods that use systematic, quantitative and unbiased approaches are making it possible to discover proteins altered by a disease. To identify proteins that might be differentially expressed in autism, serum proteins from blood were subjected to trypsin digestion followed by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) on time-of-flight (TOF) instruments to identify differentially expressed peptides. Children with autism 4-6 years of age (n=69) were compared to typically developing children (n=35) with similar age and gender distributions. A total of 6348 peptide components were quantified. Of these, five peptide components corresponding to four known proteins had an effect size >0.99 with a P<0.05 and a Mascot identification score of 30 or greater for autism compared to controls. The four proteins were: Apolipoprotein (apo) B-100, Complement Factor H Related Protein (FHR1), Complement C1q and Fibronectin 1 (FN1). In addition, apo B-100 and apo A-IV were higher in children with high compared to low functioning autism. Apos are involved in the transport of lipids, cholesterol and vitamin E. The complement system is involved in the lysis and removal of infectious organisms in blood, and may be involved in cellular apoptosis in brain. Despite limitations of the study, including the low fold changes and variable detection rates for the peptide components, the data support possible differences of circulating proteins in autism, and should help stimulate the continued search for causes and treatments of autism by examining peripheral blood.Molecular Psychiatry advance online publication, 26 December 2006; doi:10.1038/sj.mp.4001943.    PMID: 17189958 [PubMed - as supplied by publisher]There is a connection between triglycerides and autism.Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5;141(6):666-8. Related Articles, Links    Click here to read     Abnormalities of cholesterol metabolism in autism spectrum disorders.    Tierney E, Bukelis I, RE, Ahmed K, Aneja A, Kratz L, Kelley RI.    Kennedy Krieger Institute, Baltimore, land 21211, USA. Tierneykennedykrieger (DOT) org    Although -Lemli-Opitz Syndrome (SLOS), a genetic condition of impaired cholesterol biosynthesis, is associated with autism [Tierney et al., 2001; Am J Med Genet 98:191-200.], the incidence of SLOS and other sterol disorders among individuals with autism spectrum disorders (ASD) is unknown. This study investigated (1) the incidence of biochemically diagnosed SLOS in blood samples from a cohort of subjects with ASD from families in which more than one individual had ASD and (2) the type and incidence of other sterol disorders in the same group. Using gas chromatography/mass spectrometry, cholesterol, and its precursor sterols were quantified in 100 samples from subjects with ASD obtained from the Autism Genetic Resource Exchange (AGRE) specimen repository. Although no sample had sterol levels consistent with SLOS, 19 samples had total cholesterol levels lower than 100 mg/dl, which is below the 5th centile for children over age 2 years. These findings suggest that, in addition to SLOS, there may be other disorders of sterol metabolism or homeostasis associated with ASD.    Publication Types:        * Research Support, N.I.H., Extramural        * Research Support, Non-U.S. Gov't    PMID: 16874769 [PubMed - indexed for MEDLINE]I'm just curious if anyone in this group has ever had their child's Triglycerides checked... I've read that some parents give their children Fenugreek for social language. I did a search on Fenugreek and read that it actually has benefical effects on Triglycerides.Interestingly enough, when my son's Doctor did a blood panel recently to check his WBC/RBCs - they forgot to do the liver function part of the lab and instead I noticed on the WBC/RBC panel it showed at the bottom my son's Triglyceride level... it was off the charts (with a normal range of 30-104 mg/dL... and his was 352 (H). I couldn't believe it - because he doesn't eat a high fat diet - he is only 4 years old and not overweight. I checked with my son's Pediatricians office and the nurse said "oh well, some people might have a genetic reason why they do and he probably gets it from someone in the family"... I left a message with his Pediatrician and I'm still waiting for her to return my call.I still don't have any answers as to WHY his triglycerides are so high and I'm not going to accept that this is just an "oh well" thing. Can anyone refer me to a good Doctor that knows anything about this? ALSO, Does anyone know if there is a connection to Triglyceride levels, viral issues, and/or autism?????????????????????????????????????Someone please kindly respond,budsmom

[Guest guest]

Yes, checked and her triglyceride level was 50 ref range 30-104. Supplements

took care of all of her ASD symptoms and she was more adhd/Asperger's. I

mention this because it is thought that ASD kids have low cholesterol while

Asperger's kids have high cholesterol.

This is important, myelin sheaths are made from cholesterol and I have been

wondering if people with ASD kids should be working on raising their kids

cholesterol levels, if that's possible.

Anyone ever have their child's Triglycerides

checked?? Because...

> I'm just curious if anyone in this group has ever had their child's

> Triglycerides checked... I've read that some parents give their

> children Fenugreek for social language. I did a search on Fenugreek

> and read that it actually has benefical effects on Triglycerides.

>

> Interestingly enough, when my son's Doctor did a blood panel recently

> to check his WBC/RBCs - they forgot to do the liver function part of

> the lab and instead I noticed on the WBC/RBC panel it showed at the

> bottom my son's Triglyceride level... it was off the charts (with a

> normal range of 30-104 mg/dL... and his was 352 (H). I couldn't

> believe it - because he doesn't eat a high fat diet - he is only 4

> years old and not overweight. I checked with my son's Pediatricians

> office and the nurse said " oh well, some people might have a genetic

> reason why they do and he probably gets it from someone in the

> family " ... I left a message with his Pediatrician and I'm still

> waiting for her to return my call.

>

> I still don't have any answers as to WHY his triglycerides are so

> high and I'm not going to accept that this is just an " oh well "

> thing. Can anyone refer me to a good Doctor that knows anything

> about this? ALSO, Does anyone know if there is a connection to

> Triglyceride levels, viral issues, and/or

> autism?????????????????????????????????????

>

> Someone please kindly respond,

> budsmom

>

>

>

>

>

>

>

[Guest guest]

Thank you everyone who responded. I'm going to discuss this at my

son's next dandr appointment. budsmom :-)

>

> Yes, checked and her triglyceride level was 50 ref range 30-104.

Supplements

> took care of all of her ASD symptoms and she was more

adhd/Asperger's. I

> mention this because it is thought that ASD kids have low

cholesterol while

> Asperger's kids have high cholesterol.

>

> This is important, myelin sheaths are made from cholesterol and I

have been

> wondering if people with ASD kids should be working on raising

their kids

> cholesterol levels, if that's possible.

>

>

> Anyone ever have their child's Triglycerides

> checked?? Because...

>

>

> > I'm just curious if anyone in this group has ever had their

child's

> > Triglycerides checked... I've read that some parents give their

> > children Fenugreek for social language. I did a search on

Fenugreek

> > and read that it actually has benefical effects on Triglycerides.

> >

> > Interestingly enough, when my son's Doctor did a blood panel

recently

> > to check his WBC/RBCs - they forgot to do the liver function part

of

> > the lab and instead I noticed on the WBC/RBC panel it showed at

the

> > bottom my son's Triglyceride level... it was off the charts (with

a

> > normal range of 30-104 mg/dL... and his was 352 (H). I couldn't

> > believe it - because he doesn't eat a high fat diet - he is only 4

> > years old and not overweight. I checked with my son's

Pediatricians

> > office and the nurse said " oh well, some people might have a

genetic

> > reason why they do and he probably gets it from someone in the

> > family " ... I left a message with his Pediatrician and I'm still

> > waiting for her to return my call.

> >

> > I still don't have any answers as to WHY his triglycerides are so

> > high and I'm not going to accept that this is just an " oh well "

> > thing. Can anyone refer me to a good Doctor that knows anything

> > about this? ALSO, Does anyone know if there is a connection to

> > Triglyceride levels, viral issues, and/or

> > autism?????????????????????????????????????

> >

> > Someone please kindly respond,

> > budsmom

> >

> >

> >

> >

> >

> >

> >

[Guest guest]

One ancedote from my experience with my son:  he will eat the fat off a good steak like its manna from heaven, could it be for a need of cholesterol?  Can get him to eat much for eggs except in pancakes, but my thinking would be that egg yolk would be a better source of cholesterol and a number of other nutrients.Yes, checked and her triglyceride level was 50 ref range 30-104. Supplements took care of all of her ASD symptoms and she was more adhd/Asperger's. I mention this because it is thought that ASD kids have low cholesterol while Asperger's kids have high cholesterol.This is important, myelin sheaths are made from cholesterol and I have been wondering if people with ASD kids should be working on raising their kids cholesterol levels, if that's possible. Anyone ever have their child's Triglycerides checked?? Because...> I'm just curious if anyone in this group has ever had their child's> Triglycerides checked... I've read that some parents give their> children Fenugreek for social language. I did a search on Fenugreek> and read that it actually has benefical effects on Triglycerides.>> Interestingly enough, when my son's Doctor did a blood panel recently> to check his WBC/RBCs - they forgot to do the liver function part of> the lab and instead I noticed on the WBC/RBC panel it showed at the> bottom my son's Triglyceride level... it was off the charts (with a> normal range of 30-104 mg/dL... and his was 352 (H). I couldn't> believe it - because he doesn't eat a high fat diet - he is only 4> years old and not overweight. I checked with my son's Pediatricians> office and the nurse said "oh well, some people might have a genetic> reason why they do and he probably gets it from someone in the> family"... I left a message with his Pediatrician and I'm still> waiting for her to return my call.>> I still don't have any answers as to WHY his triglycerides are so> high and I'm not going to accept that this is just an "oh well"> thing. Can anyone refer me to a good Doctor that knows anything> about this? ALSO, Does anyone know if there is a connection to> Triglyceride levels, viral issues, and/or> autism?????????????????????????????????????>> Someone please kindly respond,> budsmom>>>>>>>

[Guest guest]

I can go you one better...ours will eat butter straight, yuck! The thing is that her cholesterol is high normal 198, upper ref range 200. But I think you should look at the good vs bad cholesterol and not the total number. Her triglycerides and good cholesterol are great, her bad cholesterol is low.

Eggs are wonderful, not only as a source of cholesterol but as high lecithin and lecithin is needed for myelin sheathing. Actually the cholesterol in eggs is dissipated by the lecithin. But if you look at the nutritional content of eggs you'd be hard pressed to find a more nutritious food.

Better yet, in addition to lots of eggs (if you have a good source of free range eggs, they can be added raw to smoothies or milk shakes with noone the wiser) give phosphatidylcholine as this nutrient helps make lecithin and make/repair myelin sheaths.

Or learn to make custards..they're sweet and contain lots of eggs.Or Flan.

Anyone ever have their child's Triglycerides checked?? Because...> I'm just curious if anyone in this group has ever had their child's> Triglycerides checked... I've read that some parents give their> children Fenugreek for social language. I did a search on Fenugreek> and read that it actually has benefical effects on Triglycerides.>> Interestingly enough, when my son's Doctor did a blood panel recently> to check his WBC/RBCs - they forgot to do the liver function part of> the lab and instead I noticed on the WBC/RBC panel it showed at the> bottom my son's Triglyceride level... it was off the charts (with a> normal range of 30-104 mg/dL... and his was 352 (H). I couldn't> believe it - because he doesn't eat a high fat diet - he is only 4> years old and not overweight. I checked with my son's Pediatricians> office and the nurse said "oh well, some people might have a genetic> reason why they do and he probably gets it from someone in the> family"... I left a message with his Pediatrician and I'm still> waiting for her to return my call.>> I still don't have any answers as to WHY his triglycerides are so> high and I'm not going to accept that this is just an "oh well"> thing. Can anyone refer me to a good Doctor that knows anything> about this? ALSO, Does anyone know if there is a connection to> Triglyceride levels, viral issues, and/or> autism?????????????????????????????????????>> Someone please kindly respond,> budsmom>>>>>>>

[Guest guest]

Budsmom,

You may want to call out to Craig w/ nutritiondynamics.com. He is well versed on this subject and recently said along w/ a detox for our son to also 'wash the liver' with lipitrophic factors as he said the liver is like a sponge and will collect many fats. He said the lipitrophic factors will slowly release the fats from the liver. Craig can be reached at - he is good resource and may have some good information that will help your son. If he is busy speaking with someone else, just leave your phone number and he will call you back. My Best to you!

Schmitt

From: mb12 valtrex [mailto:mb12 valtrex ] On Behalf Of buddybearsmomSent: Sunday, February 25, 2007 4:28 PMTo: mb12 valtrex Subject: Re: Anyone ever have their child's Triglycerides checked?? Because...

Thank you everyone who responded. I'm going to discuss this at my son's next dandr appointment. budsmom :-)>> Yes, checked and her triglyceride level was 50 ref range 30-104. Supplements > took care of all of her ASD symptoms and she was more adhd/Asperger's. I > mention this because it is thought that ASD kids have low cholesterol while > Asperger's kids have high cholesterol.> > This is important, myelin sheaths are made from cholesterol and I have been > wondering if people with ASD kids should be working on raising their kids > cholesterol levels, if that's possible.> > > Anyone ever have their child's Triglycerides > checked?? Because...> > > > I'm just curious if anyone in this group has ever had their child's> > Triglycerides checked... I've read that some parents give their> > children Fenugreek for social language. I did a search on Fenugreek> > and read that it actually has benefical effects on Triglycerides.> >> > Interestingly enough, when my son's Doctor did a blood panel recently> > to check his WBC/RBCs - they forgot to do the liver function part of> > the lab and instead I noticed on the WBC/RBC panel it showed at the> > bottom my son's Triglyceride level... it was off the charts (with a> > normal range of 30-104 mg/dL... and his was 352 (H). I couldn't> > believe it - because he doesn't eat a high fat diet - he is only 4> > years old and not overweight. I checked with my son's Pediatricians> > office and the nurse said "oh well, some people might have a genetic> > reason why they do and he probably gets it from someone in the> > family"... I left a message with his Pediatrician and I'm still> > waiting for her to return my call.> >> > I still don't have any answers as to WHY his triglycerides are so> > high and I'm not going to accept that this is just an "oh well"> > thing. Can anyone refer me to a good Doctor that knows anything> > about this? ALSO, Does anyone know if there is a connection to> > Triglyceride levels, viral issues, and/or> > autism?????????????????????????????????????> >> > Someone please kindly respond,> > budsmom> >> >> >> >> >> >> >