Re: in depth thyroid hormone text :) Update -even better 1

[Guest guest]

BJ and all

check this Other pdf out

the authors note their *surprise that no one else is writing about this topic!

--and they call for better Thryoid tests that test what is in our peripheral

tissues because any of the poitns along the 'workflow' can and do go wrong :/

note this paper is categorized under Medical Hypotheses type

those rebels

but wade thru the whole thing; i couldn't believe how many Different things i

learned (including about carnitine?)

http://cfids-cab.org/cfs-inform/Hypotheses/tjoerve.etal07.pdf

On commonness and rarity of thyroid hormone

resistance: A discussion based on mechanisms of

reduced sensitivity in peripheral tissues

2007

-Carol

just 1 topic among many that they address

Differential resistance between tissues

Patients can sometimes show clinical symptoms of

both hypothyroidism and hyperthyroidism, possibly

caused by differential resistance between tissues.

This can potentially be caused by both...

....

>

> i have been reading more about nongenomic and genomic actions of all of our

thryoid hormone types.

>

> i really like the way this DR Pepper writes

> and i just came across another of his texts ; its really amazing how much

thryoid hromones do in and outside of our cells and in so many ways.

>

> this particular paper (i had to wade thru some of the heavier stuff:) has a

number of important sentences describing many Different things that thyroid

hormones do.

>

> http://www.hotthyroidology.com/editorial_191.html

>

> NONGENOMIC ACTIONS OF THYROID HORMONE INITIATED AT THE PLASMA MEMBRANE OR IN

CYTOPLASM

> J

>

> =) this sentence seems to make a good case for ensuring that a hypot patient

is getting a high enough dose of their best RX type:

> "

> The relatively constant thyroid hormone levels in tissues of intact euthyroid

organisms means that thyroid hormone, particularly T3, is an important

contributor via nuclear thyroid hormone receptors (TRs) to the basal rate of

transcription of specific genes

> "

>

>

> =) and in terms of all the biologic actions that all the thyroid hormones can

and do generate:

> "

> ....

> The foregoing actions are seen to be initiated by thyroid hormone in

cytoplasm. They are largely T3-initiated, except for the hormonal effect on

actin polymerization which is not sensitive to T3, but is regulated by

L-thyroxine (T4) and 3, 3', 5-triiodothyronine (**reverse T3, rT3) (16, 22).

>

> The fact that an event can be initiated in cytoplasm, such as activation of

phosphatidylinositol 3-kinase (PI 3-K) by T3, and culminate in specific gene

transcription (23) is an example of an _interface between nongenomic and genomic

hormone actions.__

> There is increasing appreciation of such interfaces, as will be seen in the

subsequent discussion.

> ...

> "

>

> -Carol

> btw (this Hot Thryoidology site is owned by a lot of drs across teh world and

is a really good sign i think these DRs appear very interested in

collecting thyroid science and research information which is proving how complex

and how important thryoid /horones and actions are in the body .

>