Upregulation of 5-HT2C receptors

[Guest guest]

Epilepsy Behav. 2009 Oct;16(2):225-30. Epub 2009 Aug 22.

Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic

rats: antagonism by Bacopa monnieri.

Krishnakumar A, Nandhu MS, ose CS.

Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience,

Department of Biotechnology, Cochin University of Science and Technology, Cochin

682022, Kerala, India.

Abstract

Emotional disturbances, depressive mood, anxiety, aggressive behavior, and

memory impairment are the common psychiatric features associated with temporal

lobe epilepsy (TLE). The present study was carried out to investigate the role

of Bacopa monnieri extract in hippocampus of pilocarpine-induced temporal lobe

epileptic rats through the 5-HT(2C) receptor in relation to depression. Our

results showed upregulation of 5-HT(2C) receptors with a decreased affinity in

hippocampus of pilocarpine-induced epileptic rats. Also, there was an increase

in 5-HT(2C) gene expression and inositol triphosphate content in epileptic

hippocampus. Carbamazepine and B. monnieri treatments reversed the alterations

in 5-HT(2C) receptor binding, gene expression, and inositol triphosphate content

in treated epileptic rats as compared to untreated epileptic rats. The forced

swim test confirmed the depressive behavior pattern during epilepsy that was

nearly completely reversed by B. monnieri treatment.

[Guest guest]

now iam reading that it increase the serotine in the brain. some one ever try

this stuf?

>

> Epilepsy Behav. 2009 Oct;16(2):225-30. Epub 2009 Aug 22.

>

> Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced

epileptic rats: antagonism by Bacopa monnieri.

> Krishnakumar A, Nandhu MS, ose CS.

>

> Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience,

Department of Biotechnology, Cochin University of Science and Technology, Cochin

682022, Kerala, India.

>

> Abstract

> Emotional disturbances, depressive mood, anxiety, aggressive behavior, and

memory impairment are the common psychiatric features associated with temporal

lobe epilepsy (TLE). The present study was carried out to investigate the role

of Bacopa monnieri extract in hippocampus of pilocarpine-induced temporal lobe

epileptic rats through the 5-HT(2C) receptor in relation to depression. Our

results showed upregulation of 5-HT(2C) receptors with a decreased affinity in

hippocampus of pilocarpine-induced epileptic rats. Also, there was an increase

in 5-HT(2C) gene expression and inositol triphosphate content in epileptic

hippocampus. Carbamazepine and B. monnieri treatments reversed the alterations

in 5-HT(2C) receptor binding, gene expression, and inositol triphosphate content

in treated epileptic rats as compared to untreated epileptic rats. The forced

swim test confirmed the depressive behavior pattern during epilepsy that was

nearly completely reversed by B. monnieri treatment.

>