Re: Alzheimers - Autism herpes connection?

[Guest guest]

Here's another study on this topic from the UC MIND Institute

that hasn't even been published on paper yet.

Mol Psychiatry. 2006 Dec 26; [Epub ahead of print]

A proteomic study of serum from children with autism showing

differential expression of apolipoproteins and complement proteins.

Corbett BA, Kantor AB, Schulman H, WL, Lit L, Ashwood P,

Rocke DM, Sharp FR.

[1] 1Department of Psychiatry and Behavioral Sciences, University of

California at , Sacramento, CA, USA [2] 2Department of

Psychiatry and Behavioral Sciences, MIND Institute, University of

California at , Sacramento, CA, USA.

Modern methods that use systematic, quantitative and unbiased

approaches are making it possible to discover proteins altered by a

disease. To identify proteins that might be differentially expressed

in autism, serum proteins from blood were subjected to trypsin

digestion followed by liquid chromatography-electrospray ionization-

mass spectrometry (LC-ESI-MS) on time-of-flight (TOF) instruments to

identify differentially expressed peptides. Children with autism 4-6

years of age (n=69) were compared to typically developing children

(n=35) with similar age and gender distributions. A total of 6348

peptide components were quantified. Of these, five peptide

components corresponding to four known proteins had an effect size

>0.99 with a P<0.05 and a Mascot identification score of 30 or

greater for autism compared to controls. The four proteins were:

Apolipoprotein (apo) B-100, Complement Factor H Related Protein

(FHR1), Complement C1q and Fibronectin 1 (FN1). In addition, apo B-

100 and apo A-IV were higher in children with high compared to low

functioning autism. Apos are involved in the transport of lipids,

cholesterol and vitamin E. The complement system is involved in the

lysis and removal of infectious organisms in blood, and may be

involved in cellular apoptosis in brain. Despite limitations of the

study, including the low fold changes and variable detection rates

for the peptide components, the data support possible differences of

circulating proteins in autism, and should help stimulate the

continued search for causes and treatments of autism by examining

peripheral blood.Molecular Psychiatry advance online publication, 26

December 2006; doi:10.1038/sj.mp.4001943.

Vance

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> From

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http://www.livescience.com/humanbiology/070103_herpes_alzheimers.html

>

> Herpes Might Cause Alzheimer's

[Guest guest]

Can anyone explain what significance these biological blood proteins have in terms of potential treatment?

Re: Alzheimers - Autism herpes connection?

Here's another study on this topic from the UC MIND Institute that hasn't even been published on paper yet. Mol Psychiatry. 2006 Dec 26; [Epub ahead of print] A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins. Corbett BA, Kantor AB, Schulman H, WL, Lit L, Ashwood P, Rocke DM, Sharp FR. [1] 1Department of Psychiatry and Behavioral Sciences, University of California at , Sacramento, CA, USA [2] 2Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California at , Sacramento, CA, USA. Modern methods that use systematic, quantitative and unbiased approaches are making it possible to discover proteins altered by a disease. To identify proteins that might be differentially expressed in autism, serum proteins from blood were subjected to trypsin digestion followed by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) on time-of-flight (TOF) instruments to identify differentially expressed peptides. Children with autism 4-6 years of age (n=69) were compared to typically developing children (n=35) with similar age and gender distributions. A total of 6348 peptide components were quantified. Of these, five peptide components corresponding to four known proteins had an effect size >0.99 with a P<0.05 and a Mascot identification score of 30 or greater for autism compared to controls. The four proteins were: Apolipoprotein (apo) B-100, Complement Factor H Related Protein (FHR1), Complement C1q and Fibronectin 1 (FN1). In addition, apo B-100 and apo A-IV were higher in children with high compared to low functioning autism. Apos are involved in the transport of lipids, cholesterol and vitamin E. The complement system is involved in the lysis and removal of infectious organisms in blood, and may be involved in cellular apoptosis in brain. Despite limitations of the study, including the low fold changes and variable detection rates for the peptide components, the data support possible differences of circulating proteins in autism, and should help stimulate the continued search for causes and treatments of autism by examining peripheral blood.Molecular Psychiatry advance online publication, 26 December 2006; doi:10.1038/sj.mp.4001943.Vance>> From> > http://www.livescience.com/humanbiology/070103_herpes_alzheimers.html> > Herpes Might Cause Alzheimer's

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[Guest guest]

I think the significance is in this quote from

http://www.livescience.com/humanbiology/070103_herpes_alzheimers.html

<<Quote>>

The researchers, at the University of Rochester Medical Center,

found that ApoE-4 effectively puts out a welcome mat for the herpes

virus, allowing it to be more active in the brain.

" The data suggest that ApoE-4 may support the ability of HSV to be a

more virulent pathogen, " said Federoff, lead author of the

research published online in the journal Neurobiology of Aging.

The research involved measuring the activity levels of HSV in the

brains of mice with different forms of the human ApoE gene.

The team found that the virus infiltrates brain cells about the same

whether or not mice have the ApoE-4 form of the gene. But in mice

with the ApoE-4 version, the virus is less likely to be latent and

thus more likely to multiply.

Scientists have known for several years that the ApoE-4 gene plays a

role in Alzheimer's but the idea that it works in concert with the

herpes virus is new.

<<Quote>>

So it isn't the proteins themselves but antivirals against the

herpesviruses (including but not limited to Valtrex) that offer

significant possibilities in treatment.

Vance

>

> Can anyone explain what significance these biological blood

proteins have in terms of potential treatment?