CMO informatio

[Guest guest]

Hi,

Below is what I found in my files on CMO. Hope it helps.

Just want to say that Bradley is held in the highest esteem and is a

genuine hero in every sense of the word!

Jean

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Call J. Wasson at in NC. His is 100 pure and is the original

formula -- and is cheap in volume.

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Cetyl Myristoleate: A Unique Natural Compound, Valuable in Arthritis

Conditions

A Sponsored Article

by Dr. Cochran and Dr. Dent

Introduction

Arthritis is a disease of epidemic proportions, but it has been

around for so many centuries that it is considered by most people as

a part of growing old or a consequence of physical injury. Arthritis

is in fact a far more complex disease than is generally known. For

instance, Dorland's Medical Dictionary describes 27 different types

of arthritis, and that does not include such diverse conditions as

systemic lupus erythematosus, scleroderma, fibromyalgia, and numerous

other conditions which some authorities consider to be types of

arthritis.1 One authority states that there are approximately 100

causes for arthritis.2

Arthritis is thought to affect more than 50 million Americans,

and is generally accepted to be the leading cause of movement

limitation and disability. It deserves and receives a great deal of

research and medical attention. There are hundreds of drugs,

procedures, and medical aids and devices directed at coping with the

many manifestations of the disease. Given this degree of complexity,

certainly no one agent alone could ever be expected to manage or

cure " arthritis " in its entirety. New agents take their place in the

spectrum and make a contribution. Now there is a relatively new

discovery of a natural substance, cetyl myristoleate, which shows

promise of making a great contribution in non-infective types of

arthritis.

Cetyl Myristoleate

Cetyl myristoleate was discovered and isolated by one person,

working alone, on a quest to find a cure for arthritis. Harry W.

Diehl, while employed by the National Institute of Arthritis,

Metabolism, and Digestive Diseases, specialized in sugar chemistry.

He used his chemical knowledge and research instincts to great

advantage, identifying and characterizing over 500 compounds, several

of which were patented by the National Institutes of Health (NIH).

His most significant discovery before cetyl myristoleate was a method

of synthesizing 2-deoxydextroribose, a sugar used in the preparation

of oral polio vaccine by Dr. Jonas Salk.3

Diehl's interest in discovering a way to help victims of

arthritis began over 40 years ago when his friend and next door

neighbor, a carpenter, developed severe rheumatoid arthritis. His

condition deteriorated over time until he became disabled. The

neighbor had a family to support, but his arthritis made that

impossible. Diehl is a deeply religious man whose feelings

overwhelmed him as his friend's condition worsened. Harry

thought, " Here I am working at the National Institutes of Health, and

I have never seen anything that was good for curing arthritis. " 4 He

decided to establish a laboratory in his home and embark on a search

for something to relieve the pain and disability of his neighbor and

the millions of people who suffer from arthritis. Unfortunately, he

was too late to help the neighbor, but Diehl's research did lead to

the discovery of cetyl myristoleate, which may someday be hailed as

one of the significant nutritional discoveries of the 20th century.

The Quest

As a researcher, Diehl knew that finding a cure for arthritis

first meant inducing the disease experimentally in research animals.

He started with mice, and quickly realized that he was unable to

induce arthritis in them. Diehl said he tried every way he could to

give those mice arthritis, but they just would not get it. Then, he

contacted a researcher in California who wrote to him, " If you or

anyone else can give mice arthritis, I want to know about it, because

mice are 100% immune to arthritis. " 5 At that moment, Diehl's research

instincts told him that what he wanted was already somewhere in those

mice.

It was a long, tedious job, working on his own in his spare time,

but Diehl finally found the factor - cetyl myristoleate - that

protected mice from arthritis. As Diehl said, " It didn't come on a

silver platter to me, but after years of chemical sleuthing and just

old-fashioned chemical cooking, I found it! " On thin layer

chromatography of methylene chloride extract from macerated mice,

Diehl noticed a mysterious compound, which was subsequently

identified as cetyl myristoleate. As Diehl was to prove, cetyl

myristoleate circulates in the blood of mice and makes them immune to

arthritis.

Cetyl myristoleate is now known to exist in sperm whale oil and

in a small gland in the male beaver. At this time no other sources in

nature are known to contain cetyl myristoleate. While the first

amounts of cetyl myristoleate for experimentation were extracted from

mice, Diehl quickly developed a method for making cetyl myristoleate

in the lab by the esterification of myristoleic acid.

Chemistry

Cetyl myristoleate, an oil, is the hexadecyl ester of the

unsaturated fatty acid cis-9-tetradecenoic acid. The common name for

the acid is myristoleic acid. Myristoleic acid is found commonly in

fish oils, whale oils, dairy butter, and kombo butter. The chemical

formula for cetyl myristoleate is (Z)-ROCO(CH2)7CH=CH(CH2)3CH3. Cetyl

myristoleate was unrecorded in chemical literature until Diehl's

discovery was reported. The current Merck Index of Chemicals does not

list cetyl myristoleate. A search of Chemical Abstracts lists Diehl's

method of extracting cetyl myristoleate from mice but contains no

reference to cetyl myristoleate prior to his 1977 patent.

Experimentation

To test his theory that mice are immune to arthritis because of

cetyl myristoleate, Diehl began to experiment on laboratory rats.

This research was reported in an article written in conjunction with

one of his colleagues at NIH in the Journal of Pharmaceutical

Sciences.6 In summary, this paper reports that ten normal mice were

injected in the tail with Freund's Adjuvant (heat-killed desiccated

Mycobacterium butyricum) to which rats and certain other rodents are

susceptible. In a period of 10-20 days, no noticeable swelling

developed in the legs or paws. Mice in a second group were injected

in the left hind paw. Again, after 10-20 days, no swelling was

detected as determined by comparison of the measurements of paws at

the time of injection.

Then, a group of rats was injected with cetyl myristoleate, and

48 hours later, they were given the arthritis-inducing Freund's

adjuvant. A control group of rats was given Freund's adjuvant only.

Both groups of rats were observed for a total of 58 days with respect

to weight change, hind and front leg swelling, and general well-

being. All rats receiving only Freund's adjuvant developed severe

swelling of the front and hind legs, lagged in weight gain, and were

lethargic and morbid. Those receiving cetyl myristoleate before

receiving Freund's adjuvant grew an average of 5.7 times as much as

the control group and had little if any evidence of swelling or other

symptoms of polyarthritis.

The authors concluded that it was apparent that cetyl

myristoleate gave virtually complete protection against adjuvant-

induced arthritis in rats. Furthermore, a 1:1 mixture of cetyl

myristoleate and a homologue, cetyl oleate, gave results not

significantly different from administering cetyl myristoleate alone.

A Hiatus

Diehl patented his discovery in 1977, receiving a use patent for

rheumatoid arthritis. He then sought pharmaceutical companies to

conduct human trials with cetyl myristoleate, but none were

interested in his discovery. Perhaps the lack of interest was because

cetyl myristoleate was a natural substance and could not be granted a

product patent, or maybe because drug companies know they will have

to run through 25,000 to 35,000 substances before they find one that

makes it to market. Diehl had made a major nutritional discovery, and

no one was interested! Being a scientist, not a marketing expert,

Diehl let his discovery lay dormant for about 15 years.

Cetyl Myristoleate Cures

Diehl's Arthritis

As Diehl got older, he began to experience some osteoarthritis in

his hands, his knees, and his heels. His family physician tried the

usual regimen of cortisone and non-steroidal anti-inflammatory drugs

without much effect on the course of the disease. Finally his

physician told Harry he could not have any more cortisone. " So, "

Diehl said, " I thought about my discovery, and I decided to make a

batch and use it on myself. " He did, and successfully cured himself

of his osteoarthritis.

Many of his family members and friends became aware of the relief

Diehl got from his discovery, and they wanted to try it too. Time

after time, people with both rheumatoid and osteoarthritis received

astounding relief with cetyl myristoleate. Before long, family

members and friends grew into customers, and cetyl myristoleate

appeared on the market as a dietary supplement in 1991.

Clinical Observations and Usage

In common with many other natural substances and drugs, the exact

mechanism of cetyl myristoleate's physiologic activity is unclear. As

a fatty acid ester, it appears to have the same characteristics as

the essential fatty acids, linoleic and alpha linolenic acids, except

stronger and longer lasting. These fatty acids are referred to

as " essential fatty acids " because the human body cannot make them

and we must ingest them in our diets. These EFA's truly are essential

to normal cell structure and body function and function as components

of nerve cells, cell membranes, and hormone-like substances known as

prostaglandins. Many of the beneficial effects of a diet rich in

plant foods is a result of the low levels of saturated fat and the

relatively higher levels of EFA's. While a diet high in saturated fat

has been linked to many chronic diseases, a diet low in saturated fat

but high in EFA's prevents these very same diseases.7 The use of

EFA's over an extended period of time has been shown to decrease the

pain, inflammation, and limitation of motion of arthritis.8

The difference between the activity of EFA's and cetyl

myristoleate is that the quantity required and the period of time

over which EFA's are taken are markedly longer. Cetyl myristoleate is

taken in a one month course of about 13 grams, while EFA's must be

taken over extended periods, sometimes many years, and intake varies

widely from hundreds to thousands of grams. Cetyl myristoleate seems

to have properties in common with EFA's, but it acts faster and lasts

longer.

Because EFA's are necessary for normal functioning of all tissue,

it is not surprising that the list of symptoms of EFA deficiency is a

long one. In chronic inflammatory processes, the supply of EFA's is

depleted. Cetyl myristoleate appears to have the ability to correct

the imbalance created by chronic inflammation. Like EFA's, maybe

cetyl myristoleate turns off the fires of chronic inflammation by

serving as a mediator of prostaglandin formation and metabolism.

Venous blood from the gastrointestinal tract is carried to the

liver via the portal vein. With the exception of intestinal

chylomicrons that enter the lymphatics, all absorbed products pass

initially through the liver, and in most instances are extracted or

modified before passage into systemic circulation.9 Since all fatty

acids enter systemic circulation through the liver, an oil like cetyl

myristoleate would begin its systemic circulation from the liver

also. It is speculated that cetyl myristoleate stimulates the

production of immunoglobulins and series 1 and 3 prostaglandins,

which could be one explanation for why cetyl myristoleate has such

potent effect in auto-immune and inflammatory conditions.