Re: Polyphenolic Pine Bark, ADHD (GSH and GSSH)

[Guest guest]

you do know that the med you give Connor is only a bandaid for ADHD. You haven't gotten to the core to eliminate the cause.Stan Kurtz wrote: Potentially an important study that could effect ADHD, Autism and chronic illness.--------Redox Rep. 2006;11(4):163-72.The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD).Dvorakova M, Sivonova M,

Trebaticka J, Skodacek I, Waczulikova I, Muchova J,Durackova Z.Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.Attention deficit hyperactivity disorder (ADHD) belongs to the neurodevelopmental disorders characterized by impulsivity, distractibility and hyperactivity. In the pathogenesis of ADHD genetic and non-genetic factors play an important role. It is assumed that one of non-genetic factors should be oxidative stress. Pycnogenol, an extract from the pine bark, consists of bioflavonoids, catechins, procyanidins and phenolic acids. Pycnogenol acts as powerful antioxidant, chelating agent; it stimulates the activities of some enzymes, like SOD, eNOS, and exhibits other biological activities. AIM: The aim of this randomized, double-blind, placebo-controlled trial was to investigate the influence of administered

Pycnogenol or placebo on the level of reduced (GSH) and oxidized (GSSG) glutathione in children suffering from ADHD and on total antioxidant status (TAS). This is the first investigation of the redox glutathione state in relation to ADHD. RESULTS: One month of Pycnogenol administration (1 mg/kg body weight/day) caused a significant decrease in GSSG and a highly significant increase in GSH levels as well as improvement of GSH/GSSG ratio in comparison to a group of patients taking a placebo. TAS in children with ADHD was decreased in comparison with reference values. Pycnogenol administration normalizes TAS of ADHD children.PMID: 16984739 [PubMed - indexed for MEDLINE]

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[Guest guest]

I got a flyer from the Vitamin Shoppe that suggested that it needs

to be taken along with Vitamin E and C. It is potent stuff, I would

start low and slow and then ramp up.

Gayatri

>

> Potentially an important study that could effect ADHD, Autism and

chronic illness.

>

> --------

>

> Redox Rep. 2006;11(4):163-72.

>

> The effect of polyphenolic extract from pine bark, Pycnogenol on

the level of glutathione

> in children suffering from attention deficit hyperactivity

disorder (ADHD).

>

> Dvorakova M,

> Sivonova M,

> Trebaticka J,

> Skodacek I,

> Waczulikova I,

> Muchova J,

> Durackova Z.

>

> Department of Medical Chemistry, Biochemistry and Clinical

Biochemistry, Faculty of

> Medicine, Comenius University, Bratislava, Slovak Republic.

>

> Attention deficit hyperactivity disorder (ADHD) belongs to the

neurodevelopmental

> disorders characterized by impulsivity, distractibility and

hyperactivity. In the pathogenesis

> of ADHD genetic and non-genetic factors play an important role. It

is assumed that one of

> non-genetic factors should be oxidative stress. Pycnogenol, an

extract from the pine bark,

> consists of bioflavonoids, catechins, procyanidins and phenolic

acids. Pycnogenol acts as

> powerful antioxidant, chelating agent; it stimulates the

activities of some enzymes, like

> SOD, eNOS, and exhibits other biological activities. AIM: The aim

of this randomized,

> double-blind, placebo-controlled trial was to investigate the

influence of administered

> Pycnogenol or placebo on the level of reduced (GSH) and oxidized

(GSSG) glutathione in

> children suffering from ADHD and on total antioxidant status

(TAS). This is the first

> investigation of the redox glutathione state in relation to ADHD.

>

> RESULTS: One month of Pycnogenol administration (1 mg/kg body

weight/day) caused a

> significant decrease in GSSG and a highly significant increase in

GSH levels as well as

> improvement of GSH/GSSG ratio in comparison to a group of patients

taking a placebo.

> TAS in children with ADHD was decreased in comparison with

reference values.

> Pycnogenol administration normalizes TAS of ADHD children.

>

> PMID: 16984739 [PubMed - indexed for MEDLINE]

>

[Guest guest]

You can also use grape seed extract, very similiar results and gse is less

expensive and thought, by some to be superior to pycnogenol in its benefits

for adhd, gsh/gssh. Due to advertising pycnogenol is sold more frequently

here, but in Europe the preference is for gse.

Re: Polyphenolic Pine Bark, ADHD (GSH and GSSH)

>I got a flyer from the Vitamin Shoppe that suggested that it needs

> to be taken along with Vitamin E and C. It is potent stuff, I would

> start low and slow and then ramp up.

>

> Gayatri

>

>

>

>>

>> Potentially an important study that could effect ADHD, Autism and

> chronic illness.

>>

>> --------

>>

>> Redox Rep. 2006;11(4):163-72.

>>

>> The effect of polyphenolic extract from pine bark, Pycnogenol on

> the level of glutathione

>> in children suffering from attention deficit hyperactivity

> disorder (ADHD).

>>

>> Dvorakova M,

>> Sivonova M,

>> Trebaticka J,

>> Skodacek I,

>> Waczulikova I,

>> Muchova J,

>> Durackova Z.

>>

>> Department of Medical Chemistry, Biochemistry and Clinical

> Biochemistry, Faculty of

>> Medicine, Comenius University, Bratislava, Slovak Republic.

>>

>> Attention deficit hyperactivity disorder (ADHD) belongs to the

> neurodevelopmental

>> disorders characterized by impulsivity, distractibility and

> hyperactivity. In the pathogenesis

>> of ADHD genetic and non-genetic factors play an important role. It

> is assumed that one of

>> non-genetic factors should be oxidative stress. Pycnogenol, an

> extract from the pine bark,

>> consists of bioflavonoids, catechins, procyanidins and phenolic

> acids. Pycnogenol acts as

>> powerful antioxidant, chelating agent; it stimulates the

> activities of some enzymes, like

>> SOD, eNOS, and exhibits other biological activities. AIM: The aim

> of this randomized,

>> double-blind, placebo-controlled trial was to investigate the

> influence of administered

>> Pycnogenol or placebo on the level of reduced (GSH) and oxidized

> (GSSG) glutathione in

>> children suffering from ADHD and on total antioxidant status

> (TAS). This is the first

>> investigation of the redox glutathione state in relation to ADHD.

>>

>> RESULTS: One month of Pycnogenol administration (1 mg/kg body

> weight/day) caused a

>> significant decrease in GSSG and a highly significant increase in

> GSH levels as well as

>> improvement of GSH/GSSG ratio in comparison to a group of patients

> taking a placebo.

>> TAS in children with ADHD was decreased in comparison with

> reference values.

>> Pycnogenol administration normalizes TAS of ADHD children.

>>

>> PMID: 16984739 [PubMed - indexed for MEDLINE]

>>

>

>

>

>

>

>

>

[Guest guest]

Recently I posted about a supplement that

I have found most effective with my son OPC-3. It is by no means any cure

for him but as I mentioned it keeps him from catching any non stomach bug virus

surprisingly well. It also helps his attention and focus. After

reading this article I figured I would post the ingredients since they are of

interest to this thread and may explain why I find it so helpful. -

Isotonix OPC-3s.

Grape seed extract 25mg

Red Wine extract 25mg

Pine Bark Extract (pycnogenol) 25mg

Bilberry extract 25mg

Citrus Extract Bioflavonoids 25mg

Polassium 93mg

From: mb12 valtrex [mailto:mb12 valtrex ] On Behalf Of Cochran

Sent: Friday, November 03, 2006

5:08 AM

To: mb12 valtrex

Subject: Re: Re:

Polyphenolic Pine Bark, ADHD (GSH and GSSH)

You can also use grape seed extract, very similiar

results and gse is less

expensive and thought, by some to be superior to pycnogenol in its benefits

for adhd, gsh/gssh. Due to advertising pycnogenol is sold more frequently

here, but in Europe the preference is for gse.

Re: Polyphenolic Pine Bark, ADHD (GSH and GSSH)

>I got a flyer from the Vitamin Shoppe that suggested that it needs

> to be taken along with Vitamin E and C. It is potent stuff, I would

> start low and slow and then ramp up.

>

> Gayatri

>

>

>

>>

>> Potentially an important study that could effect ADHD, Autism and

> chronic illness.

>>

>> --------

>>

>> Redox Rep. 2006;11(4):163-72.

>>

>> The effect of polyphenolic extract from pine bark, Pycnogenol on

> the level of glutathione

>> in children suffering from attention deficit hyperactivity

> disorder (ADHD).

>>

>> Dvorakova M,

>> Sivonova M,

>> Trebaticka J,

>> Skodacek I,

>> Waczulikova I,

>> Muchova J,

>> Durackova Z.

>>

>> Department of Medical Chemistry, Biochemistry and Clinical

> Biochemistry, Faculty of

>> Medicine, Comenius University, Bratislava,

Slovak Republic.

>>

>> Attention deficit hyperactivity disorder (ADHD) belongs to the

> neurodevelopmental

>> disorders characterized by impulsivity, distractibility and

> hyperactivity. In the pathogenesis

>> of ADHD genetic and non-genetic factors play an important role. It

> is assumed that one of

>> non-genetic factors should be oxidative stress. Pycnogenol, an

> extract from the pine bark,

>> consists of bioflavonoids, catechins, procyanidins and phenolic

> acids. Pycnogenol acts as

>> powerful antioxidant, chelating agent; it stimulates the

> activities of some enzymes, like

>> SOD, eNOS, and exhibits other biological activities. AIM: The aim

> of this randomized,

>> double-blind, placebo-controlled trial was to investigate the

> influence of administered

>> Pycnogenol or placebo on the level of reduced (GSH) and oxidized

> (GSSG) glutathione in

>> children suffering from ADHD and on total antioxidant status

> (TAS). This is the first

>> investigation of the redox glutathione state in relation to ADHD.

>>

>> RESULTS: One month of Pycnogenol administration (1 mg/kg body

> weight/day) caused a

>> significant decrease in GSSG and a highly significant increase in

> GSH levels as well as

>> improvement of GSH/GSSG ratio in comparison to a group of patients

> taking a placebo.

>> TAS in children with ADHD was decreased in comparison with

> reference values.

>> Pycnogenol administration normalizes TAS of ADHD children.

>>

>> PMID: 16984739 [PubMed - indexed for MEDLINE]

>>

>

>

>

>

>

>

>

[Guest guest]

I had no idea. Thanks!! Do you dose once or twice a day?

Gayatri

> >>

> >> Potentially an important study that could effect ADHD, Autism

and

> > chronic illness.

> >>

> >> --------

> >>

> >> Redox Rep. 2006;11(4):163-72.

> >>

> >> The effect of polyphenolic extract from pine bark, Pycnogenol on

> > the level of glutathione

> >> in children suffering from attention deficit hyperactivity

> > disorder (ADHD).

> >>

> >> Dvorakova M,

> >> Sivonova M,

> >> Trebaticka J,

> >> Skodacek I,

> >> Waczulikova I,

> >> Muchova J,

> >> Durackova Z.

> >>

> >> Department of Medical Chemistry, Biochemistry and Clinical

> > Biochemistry, Faculty of

> >> Medicine, Comenius University, Bratislava, Slovak Republic.

> >>

> >> Attention deficit hyperactivity disorder (ADHD) belongs to the

> > neurodevelopmental

> >> disorders characterized by impulsivity, distractibility and

> > hyperactivity. In the pathogenesis

> >> of ADHD genetic and non-genetic factors play an important role.

It

> > is assumed that one of

> >> non-genetic factors should be oxidative stress. Pycnogenol, an

> > extract from the pine bark,

> >> consists of bioflavonoids, catechins, procyanidins and phenolic

> > acids. Pycnogenol acts as

> >> powerful antioxidant, chelating agent; it stimulates the

> > activities of some enzymes, like

> >> SOD, eNOS, and exhibits other biological activities. AIM: The

aim

> > of this randomized,

> >> double-blind, placebo-controlled trial was to investigate the

> > influence of administered

> >> Pycnogenol or placebo on the level of reduced (GSH) and oxidized

> > (GSSG) glutathione in

> >> children suffering from ADHD and on total antioxidant status

> > (TAS). This is the first

> >> investigation of the redox glutathione state in relation to

ADHD.

> >>

> >> RESULTS: One month of Pycnogenol administration (1 mg/kg body

> > weight/day) caused a

> >> significant decrease in GSSG and a highly significant increase

in

> > GSH levels as well as

> >> improvement of GSH/GSSG ratio in comparison to a group of

patients

> > taking a placebo.

> >> TAS in children with ADHD was decreased in comparison with

> > reference values.

> >> Pycnogenol administration normalizes TAS of ADHD children.

> >>

> >> PMID: 16984739 [PubMed - indexed for MEDLINE]

> >>

> >

> >

> >

> >

> >

> >

> >

[Guest guest]

Where do you buy it from? Seems interesting, how do you dose?

Gayatri

> >>

> >> Potentially an important study that could effect ADHD, Autism

and

> > chronic illness.

> >>

> >> --------

> >>

> >> Redox Rep. 2006;11(4):163-72.

> >>

> >> The effect of polyphenolic extract from pine bark, Pycnogenol on

> > the level of glutathione

> >> in children suffering from attention deficit hyperactivity

> > disorder (ADHD).

> >>

> >> Dvorakova M,

> >> Sivonova M,

> >> Trebaticka J,

> >> Skodacek I,

> >> Waczulikova I,

> >> Muchova J,

> >> Durackova Z.

> >>

> >> Department of Medical Chemistry, Biochemistry and Clinical

> > Biochemistry, Faculty of

> >> Medicine, Comenius University, Bratislava, Slovak Republic.

> >>

> >> Attention deficit hyperactivity disorder (ADHD) belongs to the

> > neurodevelopmental

> >> disorders characterized by impulsivity, distractibility and

> > hyperactivity. In the pathogenesis

> >> of ADHD genetic and non-genetic factors play an important role.

It

> > is assumed that one of

> >> non-genetic factors should be oxidative stress. Pycnogenol, an

> > extract from the pine bark,

> >> consists of bioflavonoids, catechins, procyanidins and phenolic

> > acids. Pycnogenol acts as

> >> powerful antioxidant, chelating agent; it stimulates the

> > activities of some enzymes, like

> >> SOD, eNOS, and exhibits other biological activities. AIM: The

aim

> > of this randomized,

> >> double-blind, placebo-controlled trial was to investigate the

> > influence of administered

> >> Pycnogenol or placebo on the level of reduced (GSH) and oxidized

> > (GSSG) glutathione in

> >> children suffering from ADHD and on total antioxidant status

> > (TAS). This is the first

> >> investigation of the redox glutathione state in relation to

ADHD.

> >>

> >> RESULTS: One month of Pycnogenol administration (1 mg/kg body

> > weight/day) caused a

> >> significant decrease in GSSG and a highly significant increase

in

> > GSH levels as well as

> >> improvement of GSH/GSSG ratio in comparison to a group of

patients

> > taking a placebo.

> >> TAS in children with ADHD was decreased in comparison with

> > reference values.

> >> Pycnogenol administration normalizes TAS of ADHD children.

> >>

> >> PMID: 16984739 [PubMed - indexed for MEDLINE]

> >>

> >

> >

> >

> >

> >

> >

> >

[Guest guest]

Where do you buy it from? Seems interesting, how do you dose?

Gayatri

> >>

> >> Potentially an important study that could effect ADHD, Autism

and

> > chronic illness.

> >>

> >> --------

> >>

> >> Redox Rep. 2006;11(4):163-72.

> >>

> >> The effect of polyphenolic extract from pine bark, Pycnogenol on

> > the level of glutathione

> >> in children suffering from attention deficit hyperactivity

> > disorder (ADHD).

> >>

> >> Dvorakova M,

> >> Sivonova M,

> >> Trebaticka J,

> >> Skodacek I,

> >> Waczulikova I,

> >> Muchova J,

> >> Durackova Z.

> >>

> >> Department of Medical Chemistry, Biochemistry and Clinical

> > Biochemistry, Faculty of

> >> Medicine, Comenius University, Bratislava, Slovak Republic.

> >>

> >> Attention deficit hyperactivity disorder (ADHD) belongs to the

> > neurodevelopmental

> >> disorders characterized by impulsivity, distractibility and

> > hyperactivity. In the pathogenesis

> >> of ADHD genetic and non-genetic factors play an important role.

It

> > is assumed that one of

> >> non-genetic factors should be oxidative stress. Pycnogenol, an

> > extract from the pine bark,

> >> consists of bioflavonoids, catechins, procyanidins and phenolic

> > acids. Pycnogenol acts as

> >> powerful antioxidant, chelating agent; it stimulates the

> > activities of some enzymes, like

> >> SOD, eNOS, and exhibits other biological activities. AIM: The

aim

> > of this randomized,

> >> double-blind, placebo-controlled trial was to investigate the

> > influence of administered

> >> Pycnogenol or placebo on the level of reduced (GSH) and oxidized

> > (GSSG) glutathione in

> >> children suffering from ADHD and on total antioxidant status

> > (TAS). This is the first

> >> investigation of the redox glutathione state in relation to

ADHD.

> >>

> >> RESULTS: One month of Pycnogenol administration (1 mg/kg body

> > weight/day) caused a

> >> significant decrease in GSSG and a highly significant increase

in

> > GSH levels as well as

> >> improvement of GSH/GSSG ratio in comparison to a group of

patients

> > taking a placebo.

> >> TAS in children with ADHD was decreased in comparison with

> > reference values.

> >> Pycnogenol administration normalizes TAS of ADHD children.

> >>

> >> PMID: 16984739 [PubMed - indexed for MEDLINE]

> >>

> >

> >

> >

> >

> >

> >

> >

[Guest guest]

We use about 150 mgs spread throughout the day.

Re: Polyphenolic Pine Bark, ADHD (GSH and GSSH)

>I had no idea. Thanks!! Do you dose once or twice a day?

>

> Gayatri

>

>

>> >>

>> >> Potentially an important study that could effect ADHD, Autism

> and

>> > chronic illness.

>> >>

>> >> --------

>> >>

>> >> Redox Rep. 2006;11(4):163-72.

>> >>

>> >> The effect of polyphenolic extract from pine bark, Pycnogenol on

>> > the level of glutathione

>> >> in children suffering from attention deficit hyperactivity

>> > disorder (ADHD).

>> >>

>> >> Dvorakova M,

>> >> Sivonova M,

>> >> Trebaticka J,

>> >> Skodacek I,

>> >> Waczulikova I,

>> >> Muchova J,

>> >> Durackova Z.

>> >>

>> >> Department of Medical Chemistry, Biochemistry and Clinical

>> > Biochemistry, Faculty of

>> >> Medicine, Comenius University, Bratislava, Slovak Republic.

>> >>

>> >> Attention deficit hyperactivity disorder (ADHD) belongs to the

>> > neurodevelopmental

>> >> disorders characterized by impulsivity, distractibility and

>> > hyperactivity. In the pathogenesis

>> >> of ADHD genetic and non-genetic factors play an important role.

> It

>> > is assumed that one of

>> >> non-genetic factors should be oxidative stress. Pycnogenol, an

>> > extract from the pine bark,

>> >> consists of bioflavonoids, catechins, procyanidins and phenolic

>> > acids. Pycnogenol acts as

>> >> powerful antioxidant, chelating agent; it stimulates the

>> > activities of some enzymes, like

>> >> SOD, eNOS, and exhibits other biological activities. AIM: The

> aim

>> > of this randomized,

>> >> double-blind, placebo-controlled trial was to investigate the

>> > influence of administered

>> >> Pycnogenol or placebo on the level of reduced (GSH) and oxidized

>> > (GSSG) glutathione in

>> >> children suffering from ADHD and on total antioxidant status

>> > (TAS). This is the first

>> >> investigation of the redox glutathione state in relation to

> ADHD.

>> >>

>> >> RESULTS: One month of Pycnogenol administration (1 mg/kg body

>> > weight/day) caused a

>> >> significant decrease in GSSG and a highly significant increase

> in

>> > GSH levels as well as

>> >> improvement of GSH/GSSG ratio in comparison to a group of

> patients

>> > taking a placebo.

>> >> TAS in children with ADHD was decreased in comparison with

>> > reference values.

>> >> Pycnogenol administration normalizes TAS of ADHD children.

>> >>

>> >> PMID: 16984739 [PubMed - indexed for MEDLINE]

>> >>

>> >

>> >

>> >

>> >

>> >

>> >

>> >

[Guest guest]

It’s a powder supplement and I use 1

½ to 2 capfulls per day.  1 cap didn’t seem quite enough.  People who

sell marketing America

products sell it.  My sister is a massage therapist and she gets it for me.  Some

Chiropractors also sell it.  It’s $65 for 90 capfullss so it lasts me about

2 months.  If you google it, you might be able to find someone or a place near

you.  If you can’t let me know and I will ask my sister where you can get

it.  -   

From: mb12 valtrex [mailto:mb12 valtrex ] On Behalf Of Gayatri Rampal

Sent: Friday, November 03, 2006

6:48 PM

To: mb12 valtrex

Subject: Re:

Polyphenolic Pine Bark, ADHD (GSH and GSSH)

Where do you buy it from? Seems interesting, how do

you dose?

Gayatri

> >>

> >> Potentially an important study that could effect ADHD, Autism

and

> > chronic illness.

> >>

> >> --------

> >>

> >> Redox Rep. 2006;11(4):163-72.

> >>

> >> The effect of polyphenolic extract from pine bark, Pycnogenol on

> > the level of glutathione

> >> in children suffering from attention deficit hyperactivity

> > disorder (ADHD).

> >>

> >> Dvorakova M,

> >> Sivonova M,

> >> Trebaticka J,

> >> Skodacek I,

> >> Waczulikova I,

> >> Muchova J,

> >> Durackova Z.

> >>

> >> Department of Medical Chemistry, Biochemistry and Clinical

> > Biochemistry, Faculty of

> >> Medicine, Comenius University, Bratislava,

Slovak Republic.

> >>

> >> Attention deficit hyperactivity disorder (ADHD) belongs to the

> > neurodevelopmental

> >> disorders characterized by impulsivity, distractibility and

> > hyperactivity. In the pathogenesis

> >> of ADHD genetic and non-genetic factors play an important role.

It

> > is assumed that one of

> >> non-genetic factors should be oxidative stress. Pycnogenol, an

> > extract from the pine bark,

> >> consists of bioflavonoids, catechins, procyanidins and phenolic

> > acids. Pycnogenol acts as

> >> powerful antioxidant, chelating agent; it stimulates the

> > activities of some enzymes, like

> >> SOD, eNOS, and exhibits other biological activities. AIM: The

aim

> > of this randomized,

> >> double-blind, placebo-controlled trial was to investigate the

> > influence of administered

> >> Pycnogenol or placebo on the level of reduced (GSH) and oxidized

> > (GSSG) glutathione in

> >> children suffering from ADHD and on total antioxidant status

> > (TAS). This is the first

> >> investigation of the redox glutathione state in relation to

ADHD.

> >>

> >> RESULTS: One month of Pycnogenol administration (1 mg/kg body

> > weight/day) caused a

> >> significant decrease in GSSG and a highly significant increase

in

> > GSH levels as well as

> >> improvement of GSH/GSSG ratio in comparison to a group of

patients

> > taking a placebo.

> >> TAS in children with ADHD was decreased in comparison with

> > reference values.

> >> Pycnogenol administration normalizes TAS of ADHD children.

> >>

> >> PMID: 16984739 [PubMed - indexed for MEDLINE]

> >>

> >

> >

> >

> >

> >

> >

> >

[Guest guest]

Gayatri,

DAN! Dr. Levinson in Miami sells it on his web site

https://secure.highspeedweb.net/~vitality/store/catalog/index.php

I'm sure if you " google " it you can find other places/better prices.

The recommended dosing is 1 mg pr. kg of body weight pr. day.

OV

>

> Where do you buy it from? Seems interesting, how do you dose?

>

> Gayatri

>

[Guest guest]

I did look at this extract long time ago because the extract comes

from a type of pine tree that exists where my sister lives in France.

Here is some extra info I saved that may help.

But I have hard time finding where to buy here in US, if anyone

knows where to buy it, please let me know.

New study: Pine bark extract reduces ADHD symptoms in children

Research shows Pycnogenol® reduces hyperactivity, increases

concentration

________________________________________

________________________________________

HOBOKEN, NJ – EMBARGOED UNTIL June 16, 2006 – A new study to be

published in the June 17 edition of the journal of European Child &

Adolescent Psychiatry shows a significant reduction of Attention-

Deficit/Hyperactivity Disorder (ADHD) symptoms in children after

supplementing with Pycnogenol® (pic-noj-en-all), an antioxidant

plant extract from the bark of the French maritime pine tree,

everyday for one month.

In the randomized, double-blind placebo-controlled study, Pycnogenol

helped reduce hyperactivity and improve attention, concentration and

motor-visual coordination in children with ADHD.

" These findings are especially notable for parents who are concerned

about overmedicating children diagnosed with ADHD. Many families are

seeking natural options to avoid the potentially dangerous side

effects of prescription drugs, " said Dr. Rohdewald, Institute

of Pharmaceutical Chemistry at Germany's University of Munster and

one of the authors of the study.

" The results of this study show Pycnogenol may serve as a safe,

effective treatment for children diagnosed with ADHD. French

maritime pine bark extract reduced hyperactivity among study

participants, while improving attention and visual-motor

coordination and concentration of these children, " said Rohdewald.

The study sampled 61 out-patients with ADHD with an average age of 9

½ years, from the Department of Child Psychology at the Children

University Hospital in Slovakia.

Forty-one patients received Pycnogenol and 16 received placebo.

Patients were not supplemented with any other drugs or with vitamins

E or C during the study. The placebo contained lactose (58 mg) and

cellulose (65 mg). Participants in the Pycnogenol group received 1

mg of Pycnogenol or placebo for every kilogram of body weight, on a

daily basis each morning, for one month.

Participants were given a basic psychiatric examination; an

evaluation by teachers and parents using the Child Attention

Problems scale (CAP), the Connor's Teacher Rating Scale (CTRS) and

Connor's Parent Rating Scale (CPRS) and a psychological

investigation before treatment, one month after the study began and

one month after the end of the study.

After one month of Pycnogenol treatment, the participants' teachers

compared the pre-test CAP and CTRS results with those scores after

one month of treatment with either Pycnogenol or placebo. There was

a significant drop in hyperactivity and inattention compared to

start of the study and placebo.

The CPRS results, evaluated by parents after one month of treatment,

showed a decrease in hyperactivity compared to the scores at the

start of the study. The results for motor-visual coordination and

concentration showed a significant increase for participants who

took Pycnogenol after one month of the study period compared to

before the study started. Participants who took placebo showed no

significant improvement in these scores.

The researchers also found that, one month after termination of

treatment, symptoms returned to their levels as measured before the

study started in the Pycnogenol group, strongly suggesting the

antioxidant's effect on reducing ADHD symptoms.

According to the U.S. Centers for Disease Control and Prevention

(CDC), 7.8% of American Children are diagnosed with ADHD and 4.3% of

children are taking medication for this disorder.

Most types of medications used to treat ADHD can be addictive and

may have major side effects. Stimulant medications such as Ritalin,

Dexedrine and Adderall are the most common treatments for ADHD and

side effects often include depression, anxiety and irritability.

The CDC estimated nearly 3,100 people are admitted to emergency

rooms each year due to stimulant drugs. An estimated 3.3 million

Americans under the age of 19 and 1.5 million Americans over the age

of 20 take ADHD medications. Pycnogenol was chosen for the study

because it continues to scientifically demonstrate health benefits

without serious side effects or addictive properties. Published

findings have demonstrated Pycnogenol's beneficial effects in heart,

circulatory, skin and cognitive function, among others.

" ADHD is affecting the quality of life for so many children and

their families. It is imperative that science explores natural means

to provide expanded treatment options. We look forward to advancing

this promising research, " said Rohdewald.

###

Pycnogenol is a natural plant extract originating from the bark of

the Maritime pine that grows along the coast of southwest France and

is found to contain a unique combination of procyanidins,

bioflavonoids and organic acids, which offer extensive natural

health benefits. The extract has been widely studied for the past 35

years and has more than 220 published studies and review articles

ensuring safety and efficacy as an ingredient. Today, Pycnogenol is

available in more than 400 dietary supplements, multi-vitamins and

health products worldwide. For more information or a copy of this

study, visit www.pycnogenol.com.

Natural Health Science Inc., (NHS) based in Hoboken, New Jersey, is

the North American distributor for Pycnogenol® (pic-noj-en-all)

brand French Maritime Pine Bark Extract on behalf of Horphag

Research. Pycnogenol® is a registered trademark of Horphag Research

Ltd., Guernsey, and its applications are protected by U.S. patents

#5,720,956 / #6,372,266 and other international patents. NHS has the

exclusive rights to market and sell Pycnogenol® and benefits from

more than 35 years of scientific research assuring the safety and

efficacy of Pycnogenol® as a dietary supplement. For more

information about Pycnogenol® visit our web site at

www.pycnogenol.com.

>

> Potentially an important study that could effect ADHD, Autism and

chronic illness.

>

> --------

>

> Redox Rep. 2006;11(4):163-72.

>

> The effect of polyphenolic extract from pine bark, Pycnogenol on

the level of glutathione

> in children suffering from attention deficit hyperactivity

disorder (ADHD).

>

> Dvorakova M,

> Sivonova M,

> Trebaticka J,

> Skodacek I,

> Waczulikova I,

> Muchova J,

> Durackova Z.

>

> Department of Medical Chemistry, Biochemistry and Clinical

Biochemistry, Faculty of

> Medicine, Comenius University, Bratislava, Slovak Republic.

>

> Attention deficit hyperactivity disorder (ADHD) belongs to the

neurodevelopmental

> disorders characterized by impulsivity, distractibility and

hyperactivity. In the pathogenesis

> of ADHD genetic and non-genetic factors play an important role. It

is assumed that one of

> non-genetic factors should be oxidative stress. Pycnogenol, an

extract from the pine bark,

> consists of bioflavonoids, catechins, procyanidins and phenolic

acids. Pycnogenol acts as

> powerful antioxidant, chelating agent; it stimulates the

activities of some enzymes, like

> SOD, eNOS, and exhibits other biological activities. AIM: The aim

of this randomized,

> double-blind, placebo-controlled trial was to investigate the

influence of administered

> Pycnogenol or placebo on the level of reduced (GSH) and oxidized

(GSSG) glutathione in

> children suffering from ADHD and on total antioxidant status

(TAS). This is the first

> investigation of the redox glutathione state in relation to ADHD.

>

> RESULTS: One month of Pycnogenol administration (1 mg/kg body

weight/day) caused a

> significant decrease in GSSG and a highly significant increase in

GSH levels as well as

> improvement of GSH/GSSG ratio in comparison to a group of patients

taking a placebo.

> TAS in children with ADHD was decreased in comparison with

reference values.

> Pycnogenol administration normalizes TAS of ADHD children.

>

> PMID: 16984739 [PubMed - indexed for MEDLINE]

>

[Guest guest]

Thanks a lot. And to everyone else who replied :-).

Gayatri

> >

> > Where do you buy it from? Seems interesting, how do you dose?

> >

> > Gayatri

> >

>

[Guest guest]

Thanks, I got it.

> > >

> > > Where do you buy it from? Seems interesting, how do you dose?

> > >

> > > Gayatri

> > >

> >

>

[Guest guest]

Polyphenolic Pine Bark, both GSE and Pine Bark are loaded with phelols.

would taking "no-phenol" enzyme help or destroy the suppliment?

vicki

[Guest guest]

If 'No Fenol' Houston enzyme is given with it, does the diminish the

antioxidant action of the GSE or Pycnogenol?

>

> Polyphenolic Pine Bark, both GSE and Pine Bark are loaded with

phelols.

>

>

>

[Guest guest]

Sorry, I don't know, but I would guess not.

Re: Polyphenolic Pine Bark, ADHD (GSH and GSSH)

> If 'No Fenol' Houston enzyme is given with it, does the diminish the

> antioxidant action of the GSE or Pycnogenol?

>

>

>

>

>>

>> Polyphenolic Pine Bark, both GSE and Pine Bark are loaded with

> phelols.

>>

>>

>>

>

>

>

>

>

>

>

[Guest guest]

Someone else asked this, Vicki, I don't know, but I don't think so, however, you would probably need lots of no phenol to override it.

Re: Re: Polyphenolic Pine Bark, ADHD (GSH and GSSH)

Polyphenolic Pine Bark, both GSE and Pine Bark are loaded with phelols.

would taking "no-phenol" enzyme help or destroy the suppliment?

vicki