Re: methylation procedure

[Guest guest]

Hi,

I tried the methylation protocol from Rich van K., and did not respond. I also

failed to respond to glutathione precursors. (Taking glutathione itself orally

is a waste, as it is digested into its individual peptides) I also added

methionine to the protocol; synthesizing methionine requires the methylation

pathway.

I have also tried d-ribose and NADH, both with no effect. I was even tested with

IVIG (immunoglobulins) for a highly activated complement pathway; it lowered the

active complement but did nothing to the symptoms. At $18K a throw, Medicare

deemed it not worthwhile. (I was lucky to even be able to try it.)

The things that have helped have been carnitine (or acetyl-carnitine), thiamine

(injected), hydroxycobalamine (by injection), CoQ10, and CFS Support Formula or

FM Support Formula from Labs (ProHealth's FM formula also works).

Neurontin and amitriptyline help with the pain, over and above Oxycontin. I

needed Fosamax, calcium and magnesium to bring me out of osteoporosis (T=-2.7);

I need magnesium in 2/3 the amount of calcium (i.e. 600 mg Ca/400mg Mg 2X/day).

[NOTE: neurontin interferes with calcium and magnesium absorption, so they have

to be taken at different times.]

Then i have to take a bunch of antihistamines and nasal steroids, as my allergy

season starts 1/1 and runs to 12/31.

I may have a somewhat different version of CFS than a lot of you. I did have an

NMR test for mitochondrial function (research subject) which found 0 aerobic

capacity, and do have severe day-after crashes. That means mitochondrial

involvement for sure. Of course, since there is no systematic work on complete

pathways, and research studies only show one facet, I can't say for sure that

mitochondrial dysfunction is the root cause. But as with everything, you need to

try it for yourself to find out what works for you. At least the methylation and

glutathione precursor protocols are fairly cheap (unlike ribose, for instance)

and easy to do. I also have a poor immune response (require 2 Pneumovax shots to

get protection which lasts less than 4 years), which has allowed a chronic yeast

infection, that occasionally flares up very painfully and has cost me one

testicle so far.

Gerald R. , Ph.D.