XMRV -Science Journals Scarier than Science Fiction

July 16, 2011

Reference:

*Infectious XMLV in Human Cultures from

Mouse Xenografts* - Help ME circle, 9 July

2011 - Co-Cure: http://bit.ly/ncSEon

~jvr

````

http://bit.ly/nCVJUH

Age of Autism

Daily Web Newspaper of the Autism Epidemic

When Science Journals are

Scarier than Science Fiction

By Kent Heckenlively, Esq.

My choice for the scariest reading of the year was

recently published in the journal Cancer Biology and

Therapy and has the unwieldly title of *Frequent

Detection of Infectious Xenotropic Leukemia Virus

(XMLV) in Human Cultures Established from Mouse

Xenografts* (http://bit.ly/oONQ5N).

For those of you who may be confused by the idea of

a " xenograft " I'll provide you with the definition given

by the U. S. Public Health Service:

*Any procedure that involves the transplantation,

implantation, or infusion into a human recipient of

either

(a) live cells, tissues, or organs from a non-human

animal source or

( human body fluids, cells, tissues or organs that

have had ex vivio contact with live non-human animal

cells, tissues, or organs.*

This covers vaccines as well as other surgical

procedures in which human tissue is manipulated prior

to transplantation.

In the scientific community mouse xenografting is

often used to manipulate cancer cells for research

purposes, among other things.

With research that has linked XMRV (which is a

xenotropic murine leukemia virus) to prostate cancer,

chronic fatigue syndrome/ME, and to a lesser extent

autism, scientists from s Hopkins University and

the University of Texas Southwestern Medical Center

as well as a few other institutions thought it made

sense to investigate the frequency of XMLVs in human

cell lines *established from mouse xenografts and to

search for the evidence of horizontal spread to other

cell lines.*

In layman's terms the question they were asking was,

*when we do xenografting with mouse biological

products how often do we get XMLVs popping up in

our samples?*

The answer they found is that six out of twenty three

(26%) mouse DNA free xenografts *were strongly

positive for MLV and their sequences had greater than

99% homology to known MLV strains.*

These samples were obtained from seven independent

laboratories.

Further on the authors wrote:

*Of the 78 non-xenograft derived cell lines maintained

in the xenograft culture containing facilities, 13 (17%)

were positive for MLV, including XMRV, a virus strain

first identified in human tissues.* (My daughter with

autism has tested positive for XMRV.) In scientific

terms this is an absolute train wreck.

This means that every surgical patient receiving any

biological product which used mouse tissue in any way

has a one in four chance of being exposed to an

XMLV.

And that also means that any biological sample which

is maintained in a facility containing xenograft cultures

has a 17% chance of becoming infected.

On the question of vaccines, let's just say that only

10% of the nearly 40 vaccines children are expected

to receive prior to the age of five contain mouse

biological products. This translates into roughly a

100% chance that our current generation of children

will be exposed to an XMLV through a vaccination.

Are you scared yet?

It gets worse.

From the article is the following passage:

*In one case XMRV virus infection to a non-xenograft

colorectal carcinoma cell line RKO was demonstrated

from an XMRV containing prostate xenograft derived

cell line 221 Rv1 even though the two cell lines had

been maintained in the same culture facility for only a

few days.*

The translation for a non-medical person is this:

XMRV is highly infectious and spreads easily.

How about this for scary?

*Provirus integration into the genome is not random,

and occurs preferentially at transcription start sites,

CpG islands, DNase-hypersensitive sites and gene

dense regions, suggesting that provirus integration

may influence transcription in the host cell.*

For those of you keeping score at home, the CpG

islands are responsible for methylation. Is any of this

starting to sound familiar? And the transcription start

sites of genes? Pretty damned important.

I know there are those who question the role of

viruses in conditions like autism and state correctly

that a well-functioning immune system will deal with

any such pathogens.

I agree.

The problem is that we don't know the immune status

of people in the population. For example, the

discovery of XMRV itself was preceded by the finding

that men with the most aggressive forms of prostate

cancer had a deficiency in their RNasel gene, lowering

the amount of an anti-viral defense enzyme their body

produced.

How widely is that RNasel mutation spread throughout

the population? Do you know the RNasel status of

your genes? Of your children? And that's just what

we know about.

And can toxic chemicals and heavy metals interfere

with your body's immune system response to

pathogens, regardless of your genetic make-up?

You betcha.

The closest example I can make is that of what

happened to the native population in the Americas

when Europeans crossed the ocean.

A natural barrier was breached and the native

population had no immunity to our pathogens. Some

experts speculate that the diesases Europeans brough

to the New World killed 90% of the native population.

While we have shared the Earth with mice and other

creatures from the dawn of history, we haven't been

culturing their cells, then injecting those cells into our

bloodstream.

We have breached a natural barrier and we need to

ask the question of what consequences have been

wrought from this decision.

In the conclusion the authors write:

*Thus laboratories handling or culturing human

xenografts should monitor for the presence of MLV,

and should consider monitoring personnel for viral

antigens or antibodies to them.

Laboratories working with xenograft cultures should

have full knowledge and understanding of the

potential biological and biohazardous risks and should

not distribute or publish their findings without full

disclosure of the virus status of their

xenograft-derived materials.*

I've heard some commentators lament what it will

take for the medical authorities to deal with this issue

seriously.

They've noted with the despair the finding of XMRV in

men with prostate cancer, those with chronic fatigue

syndrome/ME and children with autism and how it has

failed to provoke action.

They've said to me:

" These people have no problem screwing over the old

men, those with CFS/ME, and even the children. "

With this recent finding regarding the dangers of

XMLV and XMRV transmission in labs, the question

becomes,

*Will these same medical authorities screw the very

people who work for them?*

Kent Heckenlively is a Contributing Editor to Age of

Autism

July 21, 2011

I really appreciate you putting it in way that make it easier for me to

understand. Thank you.

I don't want to assume anything but would like to repost, may I?

In a message dated 7/19/2011 6:17:13 P.M. Pacific Daylight Time,

j.van.roijen@... writes: