XMRV, closely related to PERV in Human Population -new Risk Xenotransplantation?

[Guest guest]

Thanks to

Warman

Who wrote, among other things:

*....Although the author seems unaware of the

European positives he does seem to be carefully

considering the transplantations and should they be

screening for XMRV....*

~jvr

````

http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3089.2010.00607_14.x/pdf

Wiley Online Library

Xenotransplantation

OFFICIAL JOURNAL OF THE

INTERNATIONAL XENOTRANSPLANTATION

ASSOCIATION

Xenotransplantation, Volume 18, Issue

1, Article first published online: 22 FEB 2011

Xenotransplantation 2011: 18: 56–72

Printed in Singapore. All rights reserved

doi: 10.1111/j.1399-3089.2010.00607.x

© 2011 Wiley & Sons A/S.

XENOTRANSPLANTATION

Berlin Symposium on Xenotransplantation

A mouse virus, XMRV, closely

related to porcine endogenous

retroviruses in the human

population- a new risk for

xenotransplantation?

J. Denner

Koch Institute, Berlin, Germany

There is a need to carefully consider the potential

infectious risks associated with xenotransplantation.

Whereas known viruses can easily be eliminated

from donor pigs by designated pathogen free

breeding of the animals, this is not possible for

porcine endogenous retroviruses (PERVs) integrated

into the genome of all pigs and unknown viruses.

PERVs infect human cells in vitro and may

theoretically like many retroviruses induce

immunodeficiencies and/or tumours.

Recently a xenotropic murine leukaemia virusrelated

virus (XMRV), a gammaretrovirus that is closely

related to murine leukaemia viruses as well as to

PERV, has been detected in human patients with

prostate carcinoma, chronic fatigue syndrome (CFS)

and also in a small percentage of clinically healthy

individuals.

Whereas several studies showed a broad distribution

of XMRV in the USA, similar studies in Europe failed

to detect this virus in the human population (for

review see 1).

These results clearly indicate that XMRV is not

causally associated with prostate carcinoma and CFS.

Either the virus is common in the USA (may be there

are specific populations of rodents releasing this

virus) and not in Europe, or it is a laboratory

contamination.

If XMRV is indeed circulating in the human

population, it has important implications for

xenotransplantation.

A test should be developed to discriminate between

PERV and XMRV and the potential for recombination

between the two viruses should be investigated.

Recombination between the human tropic PERV-A

and the ecotropic PERV-C has been described and

recombinant PERV-A/C was characterized by

increased replication titers.

Whether XMRV and PERV recombine remains unclear,

however co-packaging and pseudotyping between

PERV and murine retroviruses have been described.

This raises new questions:

Should the xenotransplant recipient be pre-screened

for XMRV to avoid recombination?

What measures can be taken when XMRV infection is

detected in such a screen?

However, before dealing with these specific details,

it is necessary to address the important broad

questions concerning the distribution of XMRV and

its impact on human health.

Reference

1. Denner J. Detection of a gammaretrovirus, XMRV,

in the human population: Open questions and

implications for xenotransplantation. Retrovirology

2010; 7: 16.

[Guest guest]

Hi EveryOne,

A fair number of people with ME/CFS also are hypothyroid. I have often wondered

about the possibility of viruses from pigs getting into natural thyroid hormone

tablets made from desiccate porcine thyroid. As far as I know the process used

is freeze drying which probably does not kill viruses. Any thoughts?

Peace, Love and Harmony,

Bev

>

>

> Thanks to

>

> Warman

>

> Who wrote, among other things:

>

> *....Although the author seems unaware of the

> European positives he does seem to be carefully

> considering the transplantations and should they be

> screening for XMRV....*

>

>

> ~jvr