Guest guest Posted April 11, 2001 Report Share Posted April 11, 2001 I was asked by the North American Representative for DMPS to forward thefollowing to the list regarding recent misinformation circulating about DMPS.Best regards Wayne Obie> Wayne-> Thank you for forwarding the email to me concerning DMPS. Unfortunatelythis> appears to be a case of a little knowledge.....> All the facts in regard to the Canadian arsenic poisoning cases are not> presented here. Since the information is confidential I am not at libertyto> reveal everything, however this is what I can tell you:> The poisonings in Canada were ACUTE cases - not chronic. There wasdifficulty> in determining each persons exact exposure since they did not all receivean> equal dose of arsenic. The use of DMPS was to prevent the known effects of> arsenic which is increased risk of cancer. Arsenic itself can cause skin> reactions. The physician in charge did not arbitrarily search theliterature> and decide to use DMPS. He is an experienced toxicologist and has usedDMPS> in the past. Everyone was aware of the potential side effects. It has notyet> been determined if DMPS caused the rashes. By the way , all of the> Canadians recovered.>> The person (or persons) that poisoned the coffee machine has not been> discovered , this means this situation could happen again. I asked the> physician what he would do if this situation presented itself again. He> indicated he would still use DMPS but would also institute other measures.He> has used DMPS in the past without incident.>> Acute metal poisonings can cause a lot of symptoms and effects that arenot> seen in chronic cases. So one should be careful when trying to extrapolate> information from acute poisoning situations when evaluating a chronic> poisoning.>> There was a severe mercury poisoning incidence last year in Peru which> involved about 50 children (as well as adults). DMPS was used in theseacute> poisoning cases without incident and everyone recovered.>> There is the potential for side effects from any drug (and even fromnatural> remedies when used in therapeutic application). Even the list members of> autism/mercury and dental at have seen this - case inpoint - a> young mother chelating her 3 yr. old with DMSA at a dose of 50mg/kg/bwevery> four hours. (This dose is not recommended by the manufacturer.) Child> developed an itchy rash and she wondered what to do. The responses werethat> this was mercury coming out. Maybe it was -- but this is also a commonside> effect of DMSA.>> It is interesting to note that when someone gets a rash from DMSA people> attribute this to the metal coming through the skin and thinks this is agood> thing, but if it happens with DMPS, immediately the drug is to blame. I> wonder if there is a DMSA backfire web site? In my many conversationswith> board certified toxicologists - their preference is DMPS over DMSA. People> believe that DMSA is less toxic than DMPS. Not according to Ellenhorn's> Medical Toxicology, second edition.>> These drugs are similar in that they are both next generation moleculesfrom> BAL (British anti-lewisite). DMSA is only FDA approved for use in children> with lead poisoning with blood lead levels of 45 ug/dl or greater.Starting> doses are listed in the PDR as 10mg/kg or 350mg/m2 every eight hours.> Initialization of therapy at higher doses is not recommended.(Manufacturer> information as it appears in the Physician's Desk Reference.) Also - ifit> is compounded it is not FDA approved. Only the brand name Chemet is FDA> approved. Drugs that are compounded are not approved by the FDA.>> Unfortunately there is a lot of misinformation among the lay public about> DMPS (and even among doctors). As of this date (April 2001) DMPS is notFDA> approved in the United States or Canada or any individual state. Itappears> on the FDA's list of chemicals that may be used in compounding. This in no> way infers that it is FDA approved. It was included on the list as aresult> of the recommendation of professional pharmacy associations and individual> pharmacists. Unfortunately, there were persons that claimed this meant FDA> approval and were disseminating this inaccurate information. There havealso> been persons claiming individual responsibility for getting DMPS on theFDA's> list of compounds.>> As for high copper levels and DMPS - DMPS does bind to copper. Many timesin> post challenge urine results copper is seen in elevated levels. Copper> complexes with mercury and is retained in the kidney. DMPS clears thekidney> first of metals.> Also - Oral administration is the preferred route - even in acutepoisonings> with metal. Unfortunately - most physicians do not know this because ofthe> early information that was being put out there about it. Also, DMPS doesnot> crossover the blood brain barrier as has been demonstrated with other> chelators.>> For anyone who believes they are metal toxic or may need to take either of> these drugs, they should consult and be under the care of a competent> physician (MD DO) who is thoroughly familiar with these compounds and the> literature. (PhD's are not licensed to practice medicine or prescribedrugs)> These are powerful drugs - that was the intention - so that they couldsave> lives and reduce human suffering. Either can exacerbate the symptoms ofmetal> poisoning.>> DMSA is strictly an oral preparation. DMPS can be given orally, by IM orIV> ( the preferred route is oral) The administration by other means is not> recommended by the manufacturers as their is no data on their use oreffect> when made into suppositories or topical creams. Since both are dithiols -> once in solution they oxidize when exposed to air . DMPS oxidizes when> exposed to air or is buffered to a pH of 7 or greater. DMPS should not be> given by the IV drip method nor should it be mixed with anything. DMSA> manufacturer recommends a 4 week lapse after the last dose before another> chelator is administered. Neither drug should be mixed with otherchelators.>> I have family members and friends who have taken oral doses of DMPS up to> 1000mg at one time as a challenge dose ( based upon body weight asreported> in the literature) with no side effects in spite of spilling high levelsof> various metals in the urine (mercury, lead, arsenic) .>> Literally thousands of does of DMPS have been administered to people> throughout the US and Canada - most without incident. I recently spokewith a> lady who firmly believes that DMPS saved her life. She did not do wellwith> DMSA.>> Drugs affect everyone differently. The "pre" dosing test of injecting DMPS> under the skin in no way can predict who might react to it. DMPS insolution> is very acidic and any acidic solution (even diluted) is going to causesome> type of reaction. If they try to buffer it with saline it will oxidize the> DMPS and who knows what this will cause. There is no data.>> Generally, in persons who have asthma of an allergic nature - cautionshould> be used in these persons who plan to use DMPS. Also if there is a known> sensitivity to DMPS or its salts.>> I hope this information has been of value to you and clarified yourquestions.> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 15, 2001 Report Share Posted April 15, 2001 Does anyone know where one can get oral DMPS? Thanks. Vicky _________________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2001 Report Share Posted April 16, 2001 In a message dated 4/15/01 9:33:11 PM Central Daylight Time, vidyawattie@... writes: << Does anyone know where one can get oral DMPS? Thanks. Vicky >> You need an RX from your doctor but then I think most compounding pharmacies would carry it. If not, perhaps that's a good question for the DMPS rep Wayne posted about. Gaylen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2001 Report Share Posted April 17, 2001 To Ray and others: I forwarded your comments and received the following response. Sincerely Wayne Obie DMPS > Dear Wayne - > I received the email you forwarded regarding Ray's comments about Heyl > making a statement concerning not pursuing DMPS in the US. > > Heyl/Heyltex has made no such statement. This is totally false. > > As for Jana - we are well aware of her website and the fact that she > apparently has used information from our monograph without our permission. > It would appear that she has taken some of the information out of context. > > DMPS is not FDA approved in the US or Canada and this is stamped on the > front of every monograph I send out to a physician or pharmacist. > > Since establishing the Learndmps@hotmail address I have yet to receive > email. My interpretation of this is that these people are not interested in > the scientific information, but prefer instead, to spread inaccuracies and > rumors. They did not appear to be at all interested in the scientific > information I forwarded to you previously. I think this is unfortunate. > While science is not perfect - it does attempt to look at all sides of an > issue. > > As for the Canadian arsenic poisoning cases - it remains under medical > investigation. No conclusions have yet been drawn. Acute arsenic poisoning > is not that common so there is not much data from the scientific standpoint. > > Pam Floener > US and Canadian Representative > Heyl/Heyltex > > _________________________________________________________________ > Get your FREE download of MSN Explorer at http://explorer.msn.com > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 25, 2001 Report Share Posted June 25, 2001 > Can you purchase DMPS somewhere without having to have a prescription I don't believe you can do this in the United States. >(kinda > like getting the DMSA from VRP) Quote Link to comment Share on other sites More sharing options...
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