RE: Depression, bacteria, serotonin

[Guest guest]

Thanks Jane, this is interesting. I have lupus, an autoimmune inflammatory condition. Depression is part of any exacerbation in my case. It's nice to see research being done in this area. Jane Gurin wrote: Bacteria, Serotonin, and Depression: A Possible New Approach to Treating Mood Disorders April 30, 2007 Norman Sussman, MD, DFAPA Editor, Primary Psychiatry and Psychiatry Weekly, Professor of Psychiatry, New York University School of Medicine There is growing interest in a suspected cause of some cases of depression: infection and inflammatory response. New research findings that add to our understanding of the interrelationship of immunology and depression, and the reasons that some currently used antidepressants work, may fundamentally change the way that mood disorders and drug therapies are conceptualized. There are several unambiguous examples of psychiatric illness being the result of an inflammatory or immune reaction. Considerable evidence already exists about the Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), a disorder in which Streptoccal infection triggers an

autoimmune response. The antibodies that form against the invading bacteria mistakenly recognize and “attack” certain parts of the brain, causing psychiatric symptoms. Another notable example of immune-mediated depression is the response of some patients to treatment with Interferon á, who become profoundly depressed and suicidal. Interestingly, onset of depressive symptoms has been shown to be prevented by treatment with antidepressants that work on the serotonin system. The involvement of immune activation and depressive-like “sickness behavior” symptoms has been suspected for many years. Evidence specifically suggests that patients with major depression exhibit changes in cytokine activity and inflammation. Immune-mediated psychological and neuroendocrine changes were observed following vaccination with live attenuated rubella virus. A subgroup of vulnerable subjects showed a significant virus-induced increase in depressed mood up to 10 weeks

following their vaccination. In a related animal study, the investigators also showed that immune activation with a variety of immune challenges induced a “depressive-like syndrome in rodents: anhedonia, anorexia, body weight loess, and reduced exploratory, and social behavior.” Chronic treatment with TCAs or SSRIs attenuated many of the behavioral effects. A team of English investigators have, for the first time, shown a possible link between administration of a vaccine, peripheral immune activation, psychological and behavioral changes, and the brain serotonin system. The researchers used antigens derived from the bacterium Mycobacterium vaccae, a generally benign and ubiquitous agent found in dirt. After vaccination, they found that the subsequent immune activation was temporally associated with increases in serotonin metabolism within the ventromedial prefrontal cortex. Treatment with the vaccine seemed to alter behavior in

mice similarly as is typically seen with antidepressants. This research was initiated following observations that human cancer patients being treated with the bacteria Mycobacterium vaccae unexpectedly reported increases in their quality of life. The identification of serotonin neurons in the dorsal raphe nucleus that are uniquely responsive to peripheral immune activation raises the possibility that one day there will be a vaccine designed to modulate the immune response which in turn will the prevent the onset or attenuate the symptoms of major depression and other psychiatric disorders. Ahhh...imagining that irresistible "new car" smell?Check out new cars at Yahoo! Autos.

Ahhh...imagining that irresistible "new car" smell? Check out

new cars at Yahoo! Autos.

[Guest guest]

Jane,

There really is something to this. I’ve had psoriatic

arthritis for many years and also a history of strep

infections. I’ve been on daily anti-inflammatory meds for about 7 years

and the rheumatologist has wanted me to go on methotrexate

or a similar disease modifying drug because of my worsening condition.

Before Christmas I was given an antibiotic for an infection and

noticed an improvement in my joints. I had this hazy recollection that I’d

previously heard about long-term low dose antibiotic use for the treatment of

rheumatoid type arthritis conditions, so I did some research. I came across Dr

Brown’s rheumatoid arthritis protocol that recommended the very class of

antibiotic I had been taking for the infection (tetracycline), so I asked the

MD for a longer term prescription.

I have improved to such a degree that I haven’t needed anti-inflammatories or pain killers for the past two months. I

absolutely couldn’t go longer than 24 hours previously. I’m now better

than I was when medicated and just keep getting better. I’m back to

surfing and have much more energy, so naturally my mood is a whole lot better

as well. At the rate I’m improving I imagine that I’ll now longer

have this disease by year’s end, which is an amazing thought.

So the infection connection is a genuine one I would say!

Mark Darling

Depression, bacteria, serotonin

Bacteria,

Serotonin, and Depression: A Possible New

Approach to Treating Mood Disorders

April 30, 2007

Norman Sussman, MD, DFAPA

Editor, Primary Psychiatry and Psychiatry Weekly, Professor of

Psychiatry, New York University School of Medicine

There is growing interest in a suspected cause of some cases of

depression: infection and inflammatory response. New research findings that add

to our understanding of the interrelationship of immunology and depression, and

the reasons that some currently used antidepressants work, may fundamentally

change the way that mood disorders and drug therapies are conceptualized.

There are several unambiguous examples of psychiatric illness being the

result of an inflammatory or immune reaction. Considerable evidence

already exists about the Pediatric Autoimmune Neuropsychiatric Disorders

Associated with Streptococcal Infections (PANDAS), a disorder in which

Streptoccal infection triggers an autoimmune response. The antibodies that form

against the invading bacteria mistakenly recognize and “attack”

certain parts of the brain, causing psychiatric symptoms.

Another notable example of immune-mediated depression is the response

of some patients to treatment with Interferon á, who become profoundly

depressed and suicidal. Interestingly, onset of depressive symptoms has been

shown to be prevented by treatment with antidepressants that work on the

serotonin system.

The involvement of immune activation and depressive-like

“sickness behavior” symptoms has been suspected for many years.

Evidence specifically suggests that patients with major depression exhibit

changes in cytokine activity and inflammation. Immune-mediated psychological

and neuroendocrine changes were observed following vaccination with live

attenuated rubella virus. A subgroup of vulnerable subjects showed a

significant virus-induced increase in depressed mood up to 10 weeks following

their vaccination. In a related animal study, the investigators also showed

that immune activation with a variety of immune challenges induced a

“depressive-like syndrome in rodents: anhedonia, anorexia, body weight

loess, and reduced exploratory, and social behavior.” Chronic treatment

with TCAs or SSRIs attenuated many of the behavioral effects.

A team of English investigators have, for the first

time, shown a possible link between administration of a vaccine, peripheral

immune activation, psychological and behavioral changes, and the brain serotonin

system. The researchers used antigens derived from

the bacterium Mycobacterium vaccae, a generally benign and ubiquitous agent

found in dirt. After vaccination, they found that the subsequent immune

activation was temporally associated with increases in serotonin metabolism

within the ventromedial prefrontal cortex. Treatment with the vaccine seemed to

alter behavior in mice similarly as is typically seen with antidepressants.

This research was initiated following observations that human cancer patients

being treated with the bacteria Mycobacterium vaccae unexpectedly reported

increases in their quality of life.

The identification of serotonin neurons in the dorsal raphe nucleus

that are uniquely responsive to peripheral immune activation raises the possibility

that one day there will be a vaccine designed to modulate the immune response

which in turn will the prevent the onset or attenuate the symptoms of major

depression and other psychiatric disorders.

 

Ahhh...imagining that

irresistible " new car " smell?

Check out new

cars at Yahoo! Autos.

[Guest guest]

Hi mark

Thanks for the post. I've been given a similar diagnosis so I might try running it past my GP.

Mark

RE: Depression, bacteria, serotonin

Jane,

There really is something to this. I’ve had psoriatic arthritis for many years and also a history of strep infections. I’ve been on daily anti-inflammatory meds for about 7 years and the rheumatologist has wanted me to go on methotrexate or a similar disease modifying drug because of my worsening condition.

Before Christmas I was given an antibiotic for an infection and noticed an improvement in my joints. I had this hazy recollection that I’d previously heard about long-term low dose antibiotic use for the treatment of rheumatoid type arthritis conditions, so I did some research. I came across Dr Brown’s rheumatoid arthritis protocol that recommended the very class of antibiotic I had been taking for the infection (tetracycline), so I asked the MD for a longer term prescription.

I have improved to such a degree that I haven’t needed anti-inflammatories or pain killers for the past two months. I absolutely couldn’t go longer than 24 hours previously. I’m now better than I was when medicated and just keep getting better. I’m back to surfing and have much more energy, so naturally my mood is a whole lot better as well. At the rate I’m improving I imagine that I’ll now longer have this disease by year’s end, which is an amazing thought.

So the infection connection is a genuine one I would say!

Mark Darling

-----Original Message-----From: braintrainer [mailto:braintrainer ] On Behalf Of Jane GurinSent: Wednesday, 2 May 2007 4:28 AMTo: braintrainer Subject: Depression, bacteria, serotonin

Bacteria, Serotonin, and Depression: A Possible New Approach to Treating Mood Disorders

April 30, 2007

Norman Sussman, MD, DFAPA

Editor, Primary Psychiatry and Psychiatry Weekly, Professor of Psychiatry, New York University School of Medicine

There is growing interest in a suspected cause of some cases of depression: infection and inflammatory response. New research findings that add to our understanding of the interrelationship of immunology and depression, and the reasons that some currently used antidepressants work, may fundamentally change the way that mood disorders and drug therapies are conceptualized.

There are several unambiguous examples of psychiatric illness being the result of an inflammatory or immune reaction. Considerable evidence already exists about the Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), a disorder in which Streptoccal infection triggers an autoimmune response. The antibodies that form against the invading bacteria mistakenly recognize and “attack” certain parts of the brain, causing psychiatric symptoms.

Another notable example of immune-mediated depression is the response of some patients to treatment with Interferon á, who become profoundly depressed and suicidal. Interestingly, onset of depressive symptoms has been shown to be prevented by treatment with antidepressants that work on the serotonin system.

The involvement of immune activation and depressive-like “sickness behavior” symptoms has been suspected for many years. Evidence specifically suggests that patients with major depression exhibit changes in cytokine activity and inflammation. Immune-mediated psychological and neuroendocrine changes were observed following vaccination with live attenuated rubella virus. A subgroup of vulnerable subjects showed a significant virus-induced increase in depressed mood up to 10 weeks following their vaccination. In a related animal study, the investigators also showed that immune activation with a variety of immune challenges induced a “depressive-like syndrome in rodents: anhedonia, anorexia, body weight loess, and reduced exploratory, and social behavior.” Chronic treatment with TCAs or SSRIs attenuated many of the behavioral effects.

A team of English investigators have, for the first time, shown a possible link between administration of a vaccine, peripheral immune activation, psychological and behavioral changes, and the brain serotonin system. The researchers used antigens derived from the bacterium Mycobacterium vaccae, a generally benign and ubiquitous agent found in dirt. After vaccination, they found that the subsequent immune activation was temporally associated with increases in serotonin metabolism within the ventromedial prefrontal cortex. Treatment with the vaccine seemed to alter behavior in mice similarly as is typically seen with antidepressants. This research was initiated following observations that human cancer patients being treated with the bacteria Mycobacterium vaccae unexpectedly reported increases in their quality of life.

The identification of serotonin neurons in the dorsal raphe nucleus that are uniquely responsive to peripheral immune activation raises the possibility that one day there will be a vaccine designed to modulate the immune response which in turn will the prevent the onset or attenuate the symptoms of major depression and other psychiatric disorders.

Ahhh...imagining that irresistible "new car" smell?Check out new cars at Yahoo! Autos.

[Guest guest]

Glyn,

I've read similar stuff and my son has autistic behaviour, so this is

all very interesting.

So how's the grand old duke of York? I hear they've built a " new " York

somewhere ... don't know what that's all about ... ha ha ha!

Mark

Re: Depression, bacteria, serotonin

Just to add to the mix, a few weeks ago I read an article in discover

magazine reporting a link between autism, the immune system and

inflammation.

Have a look at:

http://discovermagazine.com/2007/apr/autism-it2019s-not-just-in-the-head

Glyn Blackett

York, England

[Guest guest]

Mark,

Google “brown rheumatoid arthritis” to get more info or check

this link from Dr Mercola’s site that also

includes dietary considerations:

http://www.mercola.com/2000/aug/27/rheumatoid_arthritis.htm

The tetracycline that is supposed to work best is Minomycine.

Mark

Re:

Depression, bacteria, serotonin

Hi mark

Thanks for the post. I've been given a similar diagnosis so

I might try running it past my GP.

Mark

Depression, bacteria, serotonin

Bacteria,

Serotonin, and Depression: A Possible New

Approach to Treating Mood Disorders

April 30, 2007

Norman Sussman,

MD, DFAPA

Editor, Primary

Psychiatry and Psychiatry

Weekly, Professor of Psychiatry, New York University School of

Medicine

There is growing

interest in a suspected cause of some cases of depression: infection and

inflammatory response. New research findings that add to our understanding of

the interrelationship of immunology and depression, and the reasons that some

currently used antidepressants work, may fundamentally change the way that mood

disorders and drug therapies are conceptualized.

There are several

unambiguous examples of psychiatric illness being the result of an inflammatory

or immune reaction. Considerable evidence already exists about the

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal

Infections (PANDAS), a disorder in which Streptoccal infection triggers an

autoimmune response. The antibodies that form against the invading bacteria

mistakenly recognize and “attack” certain parts of the brain,

causing psychiatric symptoms.

Another notable

example of immune-mediated depression is the response of some patients to

treatment with Interferon á, who become profoundly depressed and suicidal.

Interestingly, onset of depressive symptoms has been shown to be prevented by

treatment with antidepressants that work on the serotonin system.

The involvement of

immune activation and depressive-like “sickness behavior” symptoms

has been suspected for many years. Evidence specifically suggests that patients

with major depression exhibit changes in cytokine activity and inflammation.

Immune-mediated psychological and neuroendocrine changes were observed

following vaccination with live attenuated rubella virus. A subgroup of

vulnerable subjects showed a significant virus-induced increase in depressed

mood up to 10 weeks following their vaccination. In a related animal study, the

investigators also showed that immune activation with a variety of immune

challenges induced a “depressive-like syndrome in rodents: anhedonia,

anorexia, body weight loess, and reduced exploratory, and social

behavior.” Chronic treatment with TCAs or SSRIs attenuated many of the

behavioral effects.

A team of English

investigators have, for the first time, shown a possible link between

administration of a vaccine, peripheral immune activation, psychological and

behavioral changes, and the brain serotonin system.

The researchers used antigens derived from the bacterium Mycobacterium vaccae,

a generally benign and ubiquitous agent found in dirt. After vaccination, they

found that the subsequent immune activation was temporally associated with

increases in serotonin metabolism within the ventromedial prefrontal cortex. Treatment

with the vaccine seemed to alter behavior in mice similarly as is typically

seen with antidepressants. This research was initiated following observations

that human cancer patients being treated with the bacteria Mycobacterium vaccae

unexpectedly reported increases in their quality of life.

The identification

of serotonin neurons in the dorsal raphe nucleus that are uniquely responsive

to peripheral immune activation raises the possibility that one day there will

be a vaccine designed to modulate the immune response which in turn will the

prevent the onset or attenuate the symptoms of major depression and other

psychiatric disorders.

Ahhh...imagining

that irresistible " new car " smell?

Check out new

cars at Yahoo! Autos.

[Guest guest]

Thank you .Very much appreciated.

Mark

RE: Depression, bacteria, serotonin

Jane,

There really is something to this. I’ve had psoriatic arthritis for many years and also a history of strep infections. I’ve been on daily anti-inflammatory meds for about 7 years and the rheumatologist has wanted me to go on methotrexate or a similar disease modifying drug because of my worsening condition.

Before Christmas I was given an antibiotic for an infection and noticed an improvement in my joints. I had this hazy recollection that I’d previously heard about long-term low dose antibiotic use for the treatment of rheumatoid type arthritis conditions, so I did some research. I came across Dr Brown’s rheumatoid arthritis protocol that recommended the very class of antibiotic I had been taking for the infection (tetracycline), so I asked the MD for a longer term prescription.

I have improved to such a degree that I haven’t needed anti-inflammatories or pain killers for the past two months. I absolutely couldn’t go longer than 24 hours previously. I’m now better than I was when medicated and just keep getting better. I’m back to surfing and have much more energy, so naturally my mood is a whole lot better as well. At the rate I’m improving I imagine that I’ll now longer have this disease by year’s end, which is an amazing thought.

So the infection connection is a genuine one I would say!

Mark Darling

-----Original Message-----From: braintrainer [mailto:braintrainer ] On Behalf Of Jane GurinSent: Wednesday, 2 May 2007 4:28 AMTo: braintrainer Subject: Depression, bacteria, serotonin

Bacteria, Serotonin, and Depression: A Possible New Approach to Treating Mood Disorders

April 30, 2007

Norman Sussman, MD, DFAPA

Editor, Primary Psychiatry and Psychiatry Weekly, Professor of Psychiatry, New York University School of Medicine

There is growing interest in a suspected cause of some cases of depression: infection and inflammatory response. New research findings that add to our understanding of the interrelationship of immunology and depression, and the reasons that some currently used antidepressants work, may fundamentally change the way that mood disorders and drug therapies are conceptualized.

There are several unambiguous examples of psychiatric illness being the result of an inflammatory or immune reaction. Considerable evidence already exists about the Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), a disorder in which Streptoccal infection triggers an autoimmune response. The antibodies that form against the invading bacteria mistakenly recognize and “attack” certain parts of the brain, causing psychiatric symptoms.

Another notable example of immune-mediated depression is the response of some patients to treatment with Interferon á, who become profoundly depressed and suicidal. Interestingly, onset of depressive symptoms has been shown to be prevented by treatment with antidepressants that work on the serotonin system.

The involvement of immune activation and depressive-like “sickness behavior” symptoms has been suspected for many years. Evidence specifically suggests that patients with major depression exhibit changes in cytokine activity and inflammation. Immune-mediated psychological and neuroendocrine changes were observed following vaccination with live attenuated rubella virus. A subgroup of vulnerable subjects showed a significant virus-induced increase in depressed mood up to 10 weeks following their vaccination. In a related animal study, the investigators also showed that immune activation with a variety of immune challenges induced a “depressive-like syndrome in rodents: anhedonia, anorexia, body weight loess, and reduced exploratory, and social behavior.” Chronic treatment with TCAs or SSRIs attenuated many of the behavioral effects.

A team of English investigators have, for the first time, shown a possible link between administration of a vaccine, peripheral immune activation, psychological and behavioral changes, and the brain serotonin system. The researchers used antigens derived from the bacterium Mycobacterium vaccae, a generally benign and ubiquitous agent found in dirt. After vaccination, they found that the subsequent immune activation was temporally associated with increases in serotonin metabolism within the ventromedial prefrontal cortex. Treatment with the vaccine seemed to alter behavior in mice similarly as is typically seen with antidepressants. This research was initiated following observations that human cancer patients being treated with the bacteria Mycobacterium vaccae unexpectedly reported increases in their quality of life.

The identification of serotonin neurons in the dorsal raphe nucleus that are uniquely responsive to peripheral immune activation raises the possibility that one day there will be a vaccine designed to modulate the immune response which in turn will the prevent the onset or attenuate the symptoms of major depression and other psychiatric disorders.

Ahhh...imagining that irresistible "new car" smell?Check out new cars at Yahoo! Autos.

[Guest guest]

Thank you .Very much appreciated.

Mark

RE: Depression, bacteria, serotonin

Jane,

There really is something to this. I’ve had psoriatic arthritis for many years and also a history of strep infections. I’ve been on daily anti-inflammatory meds for about 7 years and the rheumatologist has wanted me to go on methotrexate or a similar disease modifying drug because of my worsening condition.

Before Christmas I was given an antibiotic for an infection and noticed an improvement in my joints. I had this hazy recollection that I’d previously heard about long-term low dose antibiotic use for the treatment of rheumatoid type arthritis conditions, so I did some research. I came across Dr Brown’s rheumatoid arthritis protocol that recommended the very class of antibiotic I had been taking for the infection (tetracycline), so I asked the MD for a longer term prescription.

I have improved to such a degree that I haven’t needed anti-inflammatories or pain killers for the past two months. I absolutely couldn’t go longer than 24 hours previously. I’m now better than I was when medicated and just keep getting better. I’m back to surfing and have much more energy, so naturally my mood is a whole lot better as well. At the rate I’m improving I imagine that I’ll now longer have this disease by year’s end, which is an amazing thought.

So the infection connection is a genuine one I would say!

Mark Darling

-----Original Message-----From: braintrainer [mailto:braintrainer ] On Behalf Of Jane GurinSent: Wednesday, 2 May 2007 4:28 AMTo: braintrainer Subject: Depression, bacteria, serotonin

Bacteria, Serotonin, and Depression: A Possible New Approach to Treating Mood Disorders

April 30, 2007

Norman Sussman, MD, DFAPA

Editor, Primary Psychiatry and Psychiatry Weekly, Professor of Psychiatry, New York University School of Medicine

There is growing interest in a suspected cause of some cases of depression: infection and inflammatory response. New research findings that add to our understanding of the interrelationship of immunology and depression, and the reasons that some currently used antidepressants work, may fundamentally change the way that mood disorders and drug therapies are conceptualized.

There are several unambiguous examples of psychiatric illness being the result of an inflammatory or immune reaction. Considerable evidence already exists about the Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), a disorder in which Streptoccal infection triggers an autoimmune response. The antibodies that form against the invading bacteria mistakenly recognize and “attack” certain parts of the brain, causing psychiatric symptoms.

Another notable example of immune-mediated depression is the response of some patients to treatment with Interferon á, who become profoundly depressed and suicidal. Interestingly, onset of depressive symptoms has been shown to be prevented by treatment with antidepressants that work on the serotonin system.

The involvement of immune activation and depressive-like “sickness behavior” symptoms has been suspected for many years. Evidence specifically suggests that patients with major depression exhibit changes in cytokine activity and inflammation. Immune-mediated psychological and neuroendocrine changes were observed following vaccination with live attenuated rubella virus. A subgroup of vulnerable subjects showed a significant virus-induced increase in depressed mood up to 10 weeks following their vaccination. In a related animal study, the investigators also showed that immune activation with a variety of immune challenges induced a “depressive-like syndrome in rodents: anhedonia, anorexia, body weight loess, and reduced exploratory, and social behavior.” Chronic treatment with TCAs or SSRIs attenuated many of the behavioral effects.

A team of English investigators have, for the first time, shown a possible link between administration of a vaccine, peripheral immune activation, psychological and behavioral changes, and the brain serotonin system. The researchers used antigens derived from the bacterium Mycobacterium vaccae, a generally benign and ubiquitous agent found in dirt. After vaccination, they found that the subsequent immune activation was temporally associated with increases in serotonin metabolism within the ventromedial prefrontal cortex. Treatment with the vaccine seemed to alter behavior in mice similarly as is typically seen with antidepressants. This research was initiated following observations that human cancer patients being treated with the bacteria Mycobacterium vaccae unexpectedly reported increases in their quality of life.

The identification of serotonin neurons in the dorsal raphe nucleus that are uniquely responsive to peripheral immune activation raises the possibility that one day there will be a vaccine designed to modulate the immune response which in turn will the prevent the onset or attenuate the symptoms of major depression and other psychiatric disorders.

Ahhh...imagining that irresistible "new car" smell?Check out new cars at Yahoo! Autos.

[Guest guest]

Hi Kim,

To be honest, I’m really not sure. Evidence of the infection

would appear to vanish from time to time, but I’m not convinced that it

was really gone … perhaps just lying dormant. I had blood tests several

years ago to confirm the presence of the strep

infection, but I’m not sure which tests were done. This isn’t very

helpful is it?

Mark

Depression, bacteria, serotonin

Bacteria,

Serotonin, and Depression: A Possible New

Approach to Treating Mood Disorders

April 30, 2007

Norman Sussman, MD, DFAPA

Editor, Primary Psychiatry and Psychiatry Weekly, Professor of

Psychiatry, New York University School

of Medicine

There is growing interest in a suspected cause of some

cases of depression: infection and inflammatory response. New research findings

that add to our understanding of the interrelationship of immunology and

depression, and the reasons that some currently used antidepressants work, may

fundamentally change the way that mood disorders and drug therapies are

conceptualized.

There are several unambiguous examples of psychiatric illness being the

result of an inflammatory or immune reaction. Considerable evidence

already exists about the Pediatric Autoimmune Neuropsychiatric Disorders

Associated with Streptococcal Infections (PANDAS), a disorder in which

Streptoccal infection triggers an autoimmune response. The antibodies that form

against the invading bacteria mistakenly recognize and “attack”

certain parts of the brain, causing psychiatric symptoms.

Another notable example of immune-mediated depression is the response

of some patients to treatment with Interferon á, who become profoundly

depressed and suicidal. Interestingly, onset of depressive symptoms has been

shown to be prevented by treatment with antidepressants that work on the

serotonin system.

The involvement of immune activation and depressive-like

“sickness behavior” symptoms has been suspected for many years.

Evidence specifically suggests that patients with major depression exhibit

changes in cytokine activity and inflammation. Immune-mediated psychological

and neuroendocrine changes were observed following vaccination with live

attenuated rubella virus. A subgroup of vulnerable subjects showed a

significant virus-induced increase in depressed mood up to 10 weeks following

their vaccination. In a related animal study, the investigators also showed

that immune activation with a variety of immune challenges induced a

“depressive-like syndrome in rodents: anhedonia, anorexia, body weight

loess, and reduced exploratory, and social behavior.” Chronic treatment

with TCAs or SSRIs attenuated many of the behavioral effects.

A team of English investigators have, for the first

time, shown a possible link between administration of a vaccine, peripheral

immune activation, psychological and behavioral changes, and the brain

serotonin system. The researchers used antigens

derived from the bacterium Mycobacterium vaccae, a generally benign and

ubiquitous agent found in dirt. After vaccination, they found that the

subsequent immune activation was temporally associated with increases in

serotonin metabolism within the ventromedial prefrontal cortex. Treatment with

the vaccine seemed to alter behavior in mice similarly as is typically seen

with antidepressants. This research was initiated following observations that

human cancer patients being treated with the bacteria Mycobacterium vaccae

unexpectedly reported increases in their quality of life.

The identification of serotonin neurons in the dorsal raphe nucleus

that are uniquely responsive to peripheral immune activation raises the

possibility that one day there will be a vaccine designed to modulate the

immune response which in turn will the prevent the onset or attenuate the

symptoms of major depression and other psychiatric disorders.

Ahhh...imagining that irresistible " new car " smell?

Check out new

cars at Yahoo! Autos.

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[Guest guest]

Dear Mark.

Your experience with Long term low doses treatments, are the proof the bugs are there.

As the Tetracycline's has not other action in low doses and long term applications.

What is VERY IMPORTANT is to remember that you are also killing the normal bacterial life on the bowels

that are of huge importance to produce vitamins as well as to have the first alarm level of the Immune response " Fine Tuned " for other infections, as the greatest immune training space is placed along the bowels. So, this bad bacterial environment we create with long term antibiotic treatment's have to be restored , with the Bio products that you can get with milk products or the ones ready made for that use sold by Pharmacists.

Any of those are good enough to restore normal bacterial environment in 2 weeks of treatment. ( Is really not a " Treatment " as is only food),

The second step is to get a vaccine of wide spectrum that might cover as much as possible all species of Strepto. So that you will produce your own antibodies and then wont need to use antibiotics anymore.

There are many Blood tests to check the presence of low levels of this bugs. and the values of this Tests

are in direct relation to the " quantity " of this bugs present on your system. The danger of this bugs, is that they have a molecular structure, that is similar to our tissues, so that our immune system produces antibodies to

match that molecular structure, that at the same time is similar to your tissues, so this ends with the attack of

your antibodies your own tissues, might be brain, heart , articulations or kidneys. That is why is good to go

ahead with antibiotics till you finish this bugs. Then do the vaccines treatments.

I have some experience with this issues, so if you want to back channel about this don't hesitate to write me.

Good luck and I am very glad that you have such improvement.

Blessings

Hi Kim,

To be honest, I'm really not sure. Evidence of the infection would appear to vanish from time to time, but I'm not convinced that it was really gone … perhaps just lying dormant. I had blood tests several years ago to confirm the presence of the strep infection, but I'm not sure which tests were done. This isn't very helpful is it?

Mark

RE: Depression, bacteria, serotonin

Hi Mark, I just read your response. I am wondering if you were suffering from a strep infection all of this time or from recurring strep infections. Did you ever get a strep titer blood test done? I have read a lot about strep b/c at one time we thought my son had PANDAS and strep is pretty insidious.

KimGlacier Biofeedback <voyager@...

> wrote:

Mark,

This is wonderful! I'm so happy for your improvement. Thanks for sharing your story!

Jill

From:

braintrainer [mailto:braintrainer ] On Behalf Of Mark Darling

Sent: Tuesday, May 08, 2007 12:35 AMTo: braintrainer Subject:

RE: Depression, bacteria, serotonin

Jane,

There really is something to this. I've had psoriatic arthritis for many years and also a history of strep

infections. I've been on daily anti-inflammatory meds for about 7 years and the rheumatologist has wanted me to go on methotrexate or a similar disease modifying drug because of my worsening condition.

Before Christmas I was given an antibiotic for an infection and noticed an improvement in my joints. I had this hazy recollection that I'd previously heard about long-term low dose antibiotic use for the treatment of rheumatoid type arthritis conditions, so I did some research. I came across Dr Brown's rheumatoid arthritis protocol that recommended the very class of antibiotic I had been taking for the infection (tetracycline), so I asked the MD for a longer term prescription.

I have improved to such a degree that I haven't needed anti-inflammatories or pain killers for the past two months. I absolutely couldn't go longer than 24 hours previously. I'm now better than I was when medicated and just keep getting better. I'm back to surfing and have much more energy, so naturally my mood is a whole lot better as well. At the rate I'm improving I imagine that I'll now longer have this disease by year's end, which is an amazing thought.

So the infection connection is a genuine one I would say!

Mark Darling

-----Original Message-----From: braintrainer

[mailto:braintrainer ] On Behalf Of Jane GurinSent: Wednesday, 2 May 2007 4:28 AM

To: braintrainer Subject: Depression, bacteria, serotonin

Bacteria, Serotonin, and Depression: A Possible New Approach to Treating Mood Disorders

April 30, 2007

Norman Sussman, MD, DFAPA

Editor, Primary Psychiatry and

Psychiatry Weekly, Professor of Psychiatry, New York University School of Medicine

There is growing interest in a suspected cause of some cases of depression: infection and inflammatory response. New research findings that add to our understanding of the interrelationship of immunology and depression, and the reasons that some currently used antidepressants work, may fundamentally change the way that mood disorders and drug therapies are conceptualized.

There are several unambiguous examples of psychiatric illness being the result of an inflammatory or immune reaction. Considerable evidence already exists about the Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), a disorder in which Streptoccal infection triggers an autoimmune response. The antibodies that form against the invading bacteria mistakenly recognize and "attack" certain parts of the brain, causing psychiatric symptoms.

Another notable example of immune-mediated depression is the response of some patients to treatment with Interferon �, who become profoundly depressed and suicidal. Interestingly, onset of depressive symptoms has been shown to be prevented by treatment with antidepressants that work on the serotonin system.

The involvement of immune activation and depressive-like "sickness behavior" symptoms has been suspected for many years. Evidence specifically suggests that patients with major depression exhibit changes in cytokine activity and inflammation. Immune-mediated psychological and neuroendocrine changes were observed following vaccination with live attenuated rubella virus. A subgroup of vulnerable subjects showed a significant virus-induced increase in depressed mood up to 10 weeks following their vaccination. In a related animal study, the investigators also showed that immune activation with a variety of immune challenges induced a "depressive-like syndrome in rodents: anhedonia, anorexia, body weight loess, and reduced exploratory, and social behavior." Chronic treatment with TCAs or SSRIs attenuated many of the behavioral effects.

A team of English investigators have, for the first time, shown a possible link between administration of a vaccine, peripheral immune activation, psychological and behavioral changes, and the brain serotonin system.

The researchers used antigens derived from the bacterium Mycobacterium vaccae, a generally benign and ubiquitous agent found in dirt. After vaccination, they found that the subsequent immune activation was temporally associated with increases in serotonin metabolism within the ventromedial prefrontal cortex. Treatment with the vaccine seemed to alter behavior in mice similarly as is typically seen with antidepressants. This research was initiated following observations that human cancer patients being treated with the bacteria Mycobacterium vaccae unexpectedly reported increases in their quality of life.

The identification of serotonin neurons in the dorsal raphe nucleus that are uniquely responsive to peripheral immune activation raises the possibility that one day there will be a vaccine designed to modulate the immune response which in turn will the prevent the onset or attenuate the symptoms of major depression and other psychiatric disorders.

Ahhh...imagining that irresistible " new car " smell?Check out

new cars at Yahoo! Autos.

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[Guest guest]

,

Thanks so much for your suggestions. I have been using the

following probiotic regularly: http://www.miessence.com/WhatsNew/Offers.aspx.

It is supposed to be the world’s only certified organic probiotic

with added vitamins and minerals. I may contact you backchannel when I get the

chance.

Thanks again.

Mark

Depression, bacteria, serotonin

Bacteria, Serotonin, and Depression: A Possible New Approach to Treating Mood Disorders

April 30, 2007

Norman Sussman, MD, DFAPA

Editor, Primary Psychiatry and Psychiatry Weekly, Professor of

Psychiatry, New York University School of Medicine

There is growing interest in a suspected cause of some

cases of depression: infection and inflammatory response. New research findings

that add to our understanding of the interrelationship of immunology and

depression, and the reasons that some currently used antidepressants work, may

fundamentally change the way that mood disorders and drug therapies are

conceptualized.

There are several unambiguous examples of psychiatric

illness being the result of an inflammatory or immune reaction.

Considerable evidence already exists about the Pediatric Autoimmune

Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), a

disorder in which Streptoccal infection triggers an autoimmune response. The

antibodies that form against the invading bacteria mistakenly recognize and

" attack " certain parts of the brain, causing psychiatric symptoms.

Another notable example of immune-mediated depression

is the response of some patients to treatment with Interferon �, who become

profoundly depressed and suicidal. Interestingly, onset of depressive symptoms

has been shown to be prevented by treatment with antidepressants that work on

the serotonin system.

The involvement of immune activation and

depressive-like " sickness behavior " symptoms has been suspected for

many years. Evidence specifically suggests that patients with major depression

exhibit changes in cytokine activity and inflammation. Immune-mediated

psychological and neuroendocrine changes were observed following vaccination

with live attenuated rubella virus. A subgroup of vulnerable subjects showed a

significant virus-induced increase in depressed mood up to 10 weeks following

their vaccination. In a related animal study, the investigators also showed

that immune activation with a variety of immune challenges induced a

" depressive-like syndrome in rodents: anhedonia, anorexia, body weight

loess, and reduced exploratory, and social behavior. " Chronic treatment

with TCAs or SSRIs attenuated many of the behavioral effects.

A team of English investigators have, for the first

time, shown a possible link between administration of a vaccine, peripheral

immune activation, psychological and behavioral changes, and the brain

serotonin system. The researchers used antigens

derived from the bacterium Mycobacterium vaccae, a generally benign and

ubiquitous agent found in dirt. After vaccination, they found that the

subsequent immune activation was temporally associated with increases in

serotonin metabolism within the ventromedial prefrontal cortex. Treatment with the

vaccine seemed to alter behavior in mice similarly as is typically seen with

antidepressants. This research was initiated following observations that human

cancer patients being treated with the bacteria Mycobacterium vaccae

unexpectedly reported increases in their quality of life.

The identification of serotonin neurons in the dorsal

raphe nucleus that are uniquely responsive to peripheral immune activation

raises the possibility that one day there will be a vaccine designed to

modulate the immune response which in turn will the prevent the onset or

attenuate the symptoms of major depression and other psychiatric disorders.

Ahhh...imagining that irresistible " new car "

smell?

Check out new cars

at Yahoo! Autos.

--

No virus found in this incoming message.

Checked by AVG Free Edition.

Version: 7.5.446 / Virus Database: 269.6.2/785 - Release Date: 5/2/2007 2:16 PM

--

No virus found in this outgoing message.

Checked by AVG Free Edition.

Version: 7.5.446 / Virus Database: 269.6.2/785 - Release Date: 5/2/2007 2:16 PM

Park yourself in front of a world of choices in

alternative vehicles.

Visit

the Yahoo! Auto Green Center.

�

Never

miss an email again!

Yahoo! Toolbar alerts you the instant new Mail arrives. Check it out.

--

Dr.

Rocatti, M.D.

qdssystems@...

http://www.qeeg.com.ar

QDS Systems

Biosignal Research Tools

[Guest guest]

Cool Mark!

Please do that. There are some suggestions I want to tell you about surfing, sun exposure & Tetracycline's and joint issues, all in a whole very connected. You are welcome to write at any time. You need just a little push

to fine tune all that you have done so far , in great success and intuition. You KNOW how it feels when this

ATB works and the bugs drops and your joints get better as your general conditions. Clinical Facts can never be less important that lab findings. And lab finding can be very tricky with false positive and false negative. SPECIALLY with this nasty bug. If they have developed a stealth mode then, better to be empirical in the approach, as you have done so well.

The best for you and your dear ones.

,

Thanks so much for your suggestions. I have been using the following probiotic regularly:

http://www.miessence.com/WhatsNew/Offers.aspx. It is supposed to be the world's only certified organic probiotic with added vitamins and minerals. I may contact you backchannel when I get the chance.

Thanks again.

Mark

RE: Depression, bacteria, serotonin

Hi Mark, I just read your response. I am wondering if you were suffering from a strep infection all of this time or from recurring strep infections. Did you ever get a strep titer blood test done? I have read a lot about strep b/c at one time we thought my son had PANDAS and strep is pretty insidious.

KimGlacier Biofeedback <

voyager@... > wrote:

Mark,

This is wonderful! I'm so happy for your improvement. Thanks for sharing your story!

Jill

From:

braintrainer [mailto:

braintrainer ] On Behalf Of Mark DarlingSent: Tuesday, May 08, 2007 12:35 AM

To: braintrainer Subject:

RE: Depression, bacteria, serotonin

Jane,

There really is something to this. I've had psoriatic arthritis for many years and also a history of strep infections. I've been on daily anti-inflammatory meds for about 7 years and the rheumatologist has wanted me to go on methotrexate or a similar disease modifying drug because of my worsening condition.

Before Christmas I was given an antibiotic for an infection and noticed an improvement in my joints. I had this hazy recollection that I'd previously heard about long-term low dose antibiotic use for the treatment of rheumatoid type arthritis conditions, so I did some research. I came across Dr Brown's rheumatoid arthritis protocol that recommended the very class of antibiotic I had been taking for the infection (tetracycline), so I asked the MD for a longer term prescription.

I have improved to such a degree that I haven't needed anti-inflammatories or pain killers for the past two months. I absolutely couldn't go longer than 24 hours previously. I'm now better than I was when medicated and just keep getting better. I'm back to surfing and have much more energy, so naturally my mood is a whole lot better as well. At the rate I'm improving I imagine that I'll now longer have this disease by year's end, which is an amazing thought.

So the infection connection is a genuine one I would say!

Mark Darling

-----Original Message-----From:

braintrainer [mailto:braintrainer ]

On Behalf Of Jane GurinSent: Wednesday, 2 May 2007 4:28 AM To:

braintrainer Subject: Depression, bacteria, serotonin

Bacteria, Serotonin, and Depression: A Possible New Approach to Treating Mood Disorders

April 30, 2007

Norman Sussman, MD, DFAPA

Editor, Primary Psychiatry and

Psychiatry Weekly, Professor of Psychiatry, New York University School of Medicine

There is growing interest in a suspected cause of some cases of depression: infection and inflammatory response. New research findings that add to our understanding of the interrelationship of immunology and depression, and the reasons that some currently used antidepressants work, may fundamentally change the way that mood disorders and drug therapies are conceptualized.

There are several unambiguous examples of psychiatric illness being the result of an inflammatory or immune reaction. Considerable evidence already exists about the Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), a disorder in which Streptoccal infection triggers an autoimmune response. The antibodies that form against the invading bacteria mistakenly recognize and " attack " certain parts of the brain, causing psychiatric symptoms.

Another notable example of immune-mediated depression is the response of some patients to treatment with Interferon �, who become profoundly depressed and suicidal. Interestingly, onset of depressive symptoms has been shown to be prevented by treatment with antidepressants that work on the serotonin system.

The involvement of immune activation and depressive-like " sickness behavior " symptoms has been suspected for many years. Evidence specifically suggests that patients with major depression exhibit changes in cytokine activity and inflammation. Immune-mediated psychological and neuroendocrine changes were observed following vaccination with live attenuated rubella virus. A subgroup of vulnerable subjects showed a significant virus-induced increase in depressed mood up to 10 weeks following their vaccination. In a related animal study, the investigators also showed that immune activation with a variety of immune challenges induced a " depressive-like syndrome in rodents: anhedonia, anorexia, body weight loess, and reduced exploratory, and social behavior. " Chronic treatment with TCAs or SSRIs attenuated many of the behavioral effects.

A team of English investigators have, for the first time, shown a possible link between administration of a vaccine, peripheral immune activation, psychological and behavioral changes, and the brain serotonin system. The researchers used antigens derived from the bacterium Mycobacterium vaccae, a generally benign and ubiquitous agent found in dirt. After vaccination, they found that the subsequent immune activation was temporally associated with increases in serotonin metabolism within the ventromedial prefrontal cortex. Treatment with the vaccine seemed to alter behavior in mice similarly as is typically seen with antidepressants. This research was initiated following observations that human cancer patients being treated with the bacteria Mycobacterium vaccae unexpectedly reported increases in their quality of life.

The identification of serotonin neurons in the dorsal raphe nucleus that are uniquely responsive to peripheral immune activation raises the possibility that one day there will be a vaccine designed to modulate the immune response which in turn will the prevent the onset or attenuate the symptoms of major depression and other psychiatric disorders.

Ahhh...imagining that irresistible " new car " smell?Check out

new cars at Yahoo! Autos.

--No virus found in this incoming message.Checked by AVG Free Edition.Version: 7.5.446 / Virus Database: 269.6.2

/785 - Release Date: 5/2/2007 2:16 PM

--No virus found in this outgoing message.Checked by AVG Free Edition.Version: 7.5.446 / Virus Database: 269.6.2

/785 - Release Date: 5/2/2007 2:16 PM

Park yourself in front of a world of choices in alternative vehicles.

Visit the Yahoo! Auto Green Center.

�

Never miss an email again!Yahoo! Toolbar alerts you the instant new Mail arrives. Check it out.

-- Dr. Rocatti, M.D.qdssystems@...

http://www.qeeg.com.ar QDS SystemsBiosignal Research Tools

-- Dr. Rocatti, M.D.qdssystems@... http://www.qeeg.com.ar QDS SystemsBiosignal Research Tools