XMRV -we must not forget the Lessons of History

[Guest guest]

http://www.ukunote.com/?p=10011

Light of Sience

High degree of vigilance:

a possible new with the

HIV virus less dangerous

January 1, 2011

There are two previously known retroviruses can

infect humans and cause serious diseases: HIV

(AIDS virus) and HTLV (human T cell leukemia virus,

can cause T-cell lymphoma and T cell leukemia).

In recent years, also found a third infected human

retrovirus: XMRV (heterophile murine leukemia

virus-related virus), this virus may be associated

with prostate cancer and chronic fatigue syndrome

(CFS) related.

As might be suspected XMRV is a new virus HIV as

dangerous, XMRV's found in the international

scientific community quickly caught a huge

response.

Twenty years, the research surrounding HIV, the

international community has formed a large strength

of the professional scientific research team.

XMRV and HIV belong to the retrovirus, the past

year, specializing in HIV, which had the world's top

research institutions have the relevant research into

the XMRV become the main force of XMRV, related

research progress has been very rapid.

This year in September, the U.S. National Institutes

of Health (NIH) has organized a first international

XMRV seminar attracted 11 countries around the

world-renowned research institutions in 57 of 225

international delegates.

NIH's Dean (Francis ) personally

presided over the seminar and keynote speech, which

is rare in the history of the hospital, which is XMRV

has been unprecedented global attention as an

example.

XMRV first discovered in 2006 in men suffering from

prostate cancer tissue samples. Speculate as XMRV

virus and HIV, may be transmitted through blood

transfusion or exchange of body fluids.

July 2009, the United States invited by the NIH

Cancer Institute held a joint meeting internal and

external experts to discuss the XMRV infection on

public health.

In the October 8, 2009 the United States " Science

(Science) " A study published in the journal, the first

report of chronic fatigue syndrome (CFS) and the

potential relevance XMRV virus .

In this study, we found XMRV diagnosed in 67% of

CFS patients detected in the blood, but only 3.7% in

the blood cells of healthy individuals detected XMRV

of DNA.

Thesis of the article published in this study further

found that up to 98% of CFS patients, the virus can

be detected.

U.S. Department of Health and Human Services

(HHS) published the article of the month immediately

announced: HHS will support the assessment of

blood supply XMRV the potential risks of research

and development of standardized XMRV detection

method.

To this end, HHS has also established a special

inter-departmental " blood XMRV research group " , the

coordination of action.

As speculated XMRV and chronic fatigue syndrome

(CFS) may exist between the contact and may spread

through blood transfusion, blood transfusion in many

countries in Europe and America later authorities

have announced emergency measures, has been

indefinitely postponed or prohibited diagnosis

individual donations for the CFS.

Canada in early April this year announced a ban on

world's first blood donation in patients with CFS. In a

very short time since the countries have announced

the ban, including New Zealand, Australia, the

United States, United Kingdom.

U.S. Food and Drug Administration (FDA), NIH and

Harvard Medical School on August 23, 2010 in the

" U.S. National Academy of Sciences (PNAS) "

published on the joint, the results support the above

" Science " magazine reports.

Although they found that not XMRV, but slightly

different sequence of another murine leukemia

virus-related virus PMV, but they belong in the

classification of hepatitis C retrovirus.

United States of leading experts in anti-retroviral

Coffin ( Coffin) Professor, XMRV in the general

population of the infection may be more worthy of

attention.

Previous study healthy people XMRV infection was

3.7%, if the data can be extended to the United

States, means that the United States alone, there

are nearly 1000 million people carry the pathogenic

potential of retroviruses.

As with HIV, XMRV cause illness or death in the past

few years or decades may be in a dormant state.

These have been infected but not disease may have

spread the virus's ability, but their blood can not

limits. How to control such sources of infection, is a

more serious challenge. There is an urgent need for

energy is simple, rapid and accurate method to

detect XMRV.

U.S. NIH, FDA, Center for Disease Control and

Prevention (CDC) to take prompt action, the United

Abbott and other world-class diagnostic products

company, go all out for XMRV related diagnostic

method.

Sensitive trade surplus has been the development of

nucleic acid detection method, quantitative detection

of DNA or XMRV plasma RNA, under laboratory

conditions have been reported up to 100% accuracy

and no false positive or false negative.

XMRV has been established to the sensitive cell line

proliferation, the level of detection in single-copy

replication XMRV, and large-scale production XMRV

virus particles as antigen detection.

In addition, serological methods have been

established (such as ELISA, Western Blot, etc.) and

immunohistochemistry methods.

The next step is to shade a variety of representative

samples with reference material assembled into a

series of packages (panel), multiple testing in

multiple laboratories to test the platform

comparative analysis of the panel to determine the

standardized procedures of various detection

methods and various quality control indicators, for

eventual FDA approval, to meet the market demand.

Before and after 1984, the pathogen of AIDS in

humans and possible transmission route in some

preliminary results, the relevant administrative

departments to move slowly, leaving many countries

(including France, the United States, Germany and

other developed countries ), have appeared in the

tragic spread of AIDS through blood transfusion.

XMRV current research and found the beginning of

the HIV situation is similar. As XMR discovered not

long, the current study is far from adequate, the

results of different laboratories are sometimes

inconsistent or even conflicting.

The source of the virus and pathogenic mechanisms

are not yet established, it is with prostate cancer

and surviving the causal relationship between CFS

controversial.

But we must not forget the lessons of history must

not repeat the discovery of HIV at the beginning of

human mistakes. Must take timely and decisive

measures to prevent the manufacture of our hands

by another AIDS epidemic. With the progress of the

study may also have taken measures to require

appropriate adjustments.

XMRV momentum from the current study to see

estimated in a year or two will be able to draw

definitive conclusions.

If the XMRV really new pathogens, and humans will

be able to find effective prevention and control

methods.

CFS in the global average of 0.4% -1% incidence in

theory should also apply to China, which has never

been of great importance to CFS research. China is a

populous country, it must immediately take the

necessary action.

~~~~

[Guest guest]

re: XMRV -we must not forget

the Lessons of History

Because of a terrible brainfog [awoke at 23.00

o'clock - and started directly with reading my post],

I missed a serious flaw in the article:

*XMRV -we must not

forget the Lessons of History*

[Help ME Circle, 2 January 2001, Co-Cure:

http://bit.ly/eLzim9 ]

Thanks to s, who draw my attention

to this:

" Although they found that not XMRV, but slightly

different sequence of another murine leukemia

virus-related virus PMV, but they belong in the

classification of hepatitis C retrovirus. "

I don't believe this statement is accurate:

XMRV does not belong to the

classification of hepatitis C;

it is a Human GammaRetroVirus.