XMRV -ME/CFS & non-Hodgkin's lymphoma

[Guest guest]

http://bit.ly/eQTcKd

THE NICEGUIDELINES BLOG

Doctor Speedy and ME in search of medical honesty

November 2010

Highly increased incidence of

non-Hodgkin's lymphoma in ME/CFS

By Dr. Snyderman, an oncologist with Chronic

Lymphocytic Leukemia and ME/CFS:

XMRV has recently been identified in patients with

prostatecancer and Chronic Fatigue Syndrome (CFS).

CFS patients have an increased incidence of

lymphoproliferative malignancy compared to the normal

population.

While the incidence rate of non-Hodgkin's lymphoma is 0.02%

in the United States, nearly 5% of CFS patients developed the

disease.

A patient with CFS and CLL with adverse prognostic factors

was shown to have XMRV in plasma and CLL cells. Within the

first 100 days of treatment with AZT and raltegravir, he

showed multiple benefits simultaneous with disappearance of

infectious XMRV.

These findings suggest that XMRV is etiological for both the

CLL and CFS and that virus-direct treatment was beneficial in

this patient.

Further CLL patients should be studied especially as CLL has

been statistically associated with an increased risk for other

neoplasia.

Questions to be answered are what neoplasms are associated

with XMRV, will existing antiretrovirals have antineoplastic

activity in these neoplasms and what is the optimal

combination of antiretroviral drugs.

See abstract:

http://bit.ly/htLV2y