Guest guest Posted October 26, 2005 Report Share Posted October 26, 2005 The Germanstudy gave 3 mg!! not a larger amount.Only patients who were chronic and had a EDSS greater 5 were included.The time was only 10 days.30% showed improvement of some symptoms,not comparabel with the inteferons which show slowing progression in 30%,but this 30% was not significant,because the number of patients with 30 was so small.The german LDN study,which was not a real study was negativ. [low dose naltrexone] LDN and exaserbation >>> >>> >>> Hi Kim, >>> >>> When I had an exaserbation (attack) I upped my dose to 25mg for a >> week and it completely dissappeared. I know it is HDN but it worked >> better than steroids. I wasn't jumpy or jittery and I didn't feel like >> I needed to eat constantly. >>> >>> I had started naltrexone at 25mg because I didn't know of a >> compounding pharmacy in my area and I hadn't found the group yet. The >> 25mg worked for me because I was in a three month long exaserbation. >> The 25mg wiped out all the damage done by that exaserbation. >>> >>> I hope this works for you too. >>> >>> >>> >>> Hope all is well, >>> >> >> >> >> >> >> >> >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 26, 2005 Report Share Posted October 26, 2005 Hi FM2, You are correct in regards to the dosage. My apologies, I remembered incorrectly. Listed below is the notes from the LDN conference this year, in regards to the German study. It is important to read through (as I should have re-read before my last comments). ********************** Notes from conference regarding German LDN study: Dr Mir from Germany ran a double blind randomized trial. 60 patients, 30 on LDN, 30 on placebo, 3mg LDN TAKEN AT 9AM (no typo) .. for 10 days .. Patients were PPMS or SPMS .. Did a pre and post neurological exam and question sheet .. Now this is interesting .. the test showed that LDN did not significantly help STATISTICALLY .. however .. when you look at it closer .. one third of the patients were 'responders' ie. they responded within about 7 days ... a doctor from Ireland backed him up there .. Dr P Crowley said that the LDN website is misleading because it implies everyone will respond but in his practice only about one third of people seem to respond .. Dr Gluck clarified .. It is a bonus if you are a responder ie get improvement .. the numbers on the website include those that don't progress .. that is the cream .. the improvements are the sprinkles .. Also interesting .. although .. the trial concluded no statistical change when Dr Mir asked Docs .. 82% of docs could SEE the improvements and 72% of patients could feel them .. so there was a change .. just ones that the parameters of the trial did not pick up .. Dr Gluck pointed out it was remarkable the effects and results of the 10 day trial because LDN was taken at 9AM .. he asked that next time Dr Mir give LDN at night .. it was given in the AM to avoid sleepless nights and 3mg to avoid .. spasticity .. Dr Mir showed that although LDN works it can still fail a clinical trial .. that was an eye opener .. there are no many different parameters .. that is why it convinced me me need a large scale double blind placebo for like 300 people for 12 months that no one can dispute .. but you know .. It could even fail that depending on the parameters .. It was just fascinating .. the test in Germany ended April 2005 I think. [low dose naltrexone] LDN and exaserbation >>>> >>>> >>>> Hi Kim, >>>> >>>> When I had an exaserbation (attack) I upped my dose to 25mg for a >>> week and it completely dissappeared. I know it is HDN but it worked >>> better than steroids. I wasn't jumpy or jittery and I didn't feel like >>> I needed to eat constantly. >>>> >>>> I had started naltrexone at 25mg because I didn't know of a >>> compounding pharmacy in my area and I hadn't found the group yet. The >>> 25mg worked for me because I was in a three month long exaserbation. >>> The 25mg wiped out all the damage done by that exaserbation. >>>> >>>> I hope this works for you too. >>>> >>>> >>>> >>>> Hope all is well, >>>> >>> >>> >>> >>> >>> >>> >>> >>> >>> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 13, 2010 Report Share Posted July 13, 2010 Canukgirl I would be interested in the answer to that question as well. Charlotte Quote Link to comment Share on other sites More sharing options...
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