Type MS - treatment.

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Hi all.

How many types of MS doctors know today? - one or none!?

What do they treat?

If any of you have the doctor who give recomendation (supplements,

medication,...) relay on your symptoms, let me know, please.

That information from American Neurological Association (2005-09-23)

About NMO, that may be the first example of a novel class of

autoimmune channelopathy disorders.

" Researchers have identified a molecular suspect in a disorder

similar to multiple sclerosis (MS) that attacks the optic nerve and

spinal cord, according to a report presented at the 130th annual

meeting of the American Neurological Association in San Diego. The

protein, called aquaporin-4, is a channel protein that allows water

to move in and out of cells

For some time, scientists have understood that multiple sclerosis is

not so much a single disease, but a category of disorders with

similar damage to different parts of the nervous system. Recently,

progress has been made in teasing out a particular syndrome called

neuromyelitis optica (NMO), in which the body mistakenly mounts an

immune attack against the optic nerve and spinal cord.

Last year, Dr.Lennon and her colleagues at Mayo, along with

collaborators in Japan, were able to detect a particular antibody

that occurrs in most people with NMO, but not in patients

with " classical " MS.

This is particularly important for clinicians because specific

treatment recommendations to help prevent blindness and other later

symptoms, including paralysis, differ for NMO and MS .

Water channel proteins, which were the subject of the 2003 Nobel

Prize in Chemistry, have not been implicated in many pathological

disorders, and never in an autoimmune neurological context.

Traditionally considered a severe variant of multiple sclerosis

(MS), and commonly misdiagnosed (and inappropriately treated) as MS,

NMO is confidently distinguishable from MS when this autoantibody is

detected.

Neuromyelitis optica (NMO) selectively affects optic nerves and

spinal cord, and is considered a severe variant of multiple

sclerosis (MS). It is frequently misdiagnosed as MS, but prognosis

and optimal treatments differ.

We recently described an NMO-specific IgG in the serum of 73% of

patients with NMO, and in 58% of patients with Asian

optic-spinal MS. In patients with new onset transverse myelitis or

optic neuritis, seropositivity predicts relapse

or future development of NMO. Patients with classical MS are

seronegative...

NMO may be the first example of a novel class of autoimmune

channelopathy.