Fwd: [lymeinfo] [sci] Treatment of Chronic Neuropathic Pain in ...Late-Stage Lyme

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Dermatology

International Journal for Clinical and Investigative

Dermatology

Vol. 211, No. 2, 2005   

Medline Abstract (ID 16088158)

Pharmacology and Treatment

Gabapentin for the Symptomatic Treatment of Chronic

Neuropathic Pain in Patients with Late-Stage Lyme

Borreliosis: A Pilot Study

S. Weissenbacher, J. Ring, H. Hofmann

Department of Dermatology and Allergy Biederstein,

Technical University of Munich, Munich, Germany

Dermatology 2005;211:123-127 (DOI: 10.1159/000086441)

Key Words

Lyme borreliosis

Gabapentin

Neuropathic pain

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Abstract

Background: Chronic neuropathic pain occurs in 10-15% of

patients with neuroborreliosis and is difficult to treat.

Objective: We evaluated the effect of gabapentin

monotherapy on residual pain in patients with

neuroborreliosis after intravenous ceftriaxone treatment.

Methods: Ten patients with neuroborreliosis and a

long-lasting history of neurologic symptoms were treated

with gabapentin, starting with 300 mg/day. Doses were

raised over a period of 4-12 weeks to the individually

effective and tolerated maximum dose (500-1,200 mg).

Treatment was maintained until pain disappeared and then

gradually reduced in dose over weeks. If symptoms recurred,

the doses were raised again. Therapy was maintained over an

average of 1-2 years.

Results: Pain quality and pain quantity were evaluated

using the McGill pain questionnaire and a visual analogue

scale. There was an improvement of 'crawling' and 'burning'

pain sensations, neck and radiating lumbar pain in 9/10

(90%) patients as well as a positive effect on mood,

general feeling of health and quality of sleep in 5/10

(50%) patients. The average dose leading to a clear-cut

pain reduction was 700 mg.

Conclusions: In an open pilot study (10 patients),

gabapentin monotherapy which has to our knowledge not been

published as treatment of chronic neuropathic pain in

patients with late Lyme borreliosis is efficacious in

treating pain associated with neuroborreliosis and can thus

improve quality of life in these patients.

Copyright © 2005 S. Karger AG, Basel

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Author Contacts

Prof. Dr. H. Hofmann

Department of Dermatology and Allergy Biederstein

Biedersteinerstrasse 29

DE-80802 München (Germany)

Tel. +49 89 4140 3181, Fax +49 89 4140 3581, E-Mail

H.Hofmann@...

Article Information

Received: August 6, 2004

Accepted: October 8, 2004

Number of Print Pages : 5

Number of Figures : 1, Number of Tables : 1, Number of

References : 30

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PUBMED ID:

16088158

1: Dermatology. 2005;211(2):123-7

PMID: 16088158 [PubMed - in process]

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Hi, What's good for lyme may be good for MS??

ine

Note: forwarded message attached.

__________________________________________________