Article:Leucocyte activation in erythema nodosum.[About severity of EN]

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Dear Group,As we all know, some of us have much more severe outbreaks of EN than others.This article explores why:Leucocyte activation in erythema nodosum. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve & db=pubmed & list_uids=10564331 & dopt=Abstract Clin Exp Dermatol. 1999 Sep;24(5):396-401.

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Leucocyte activation in erythema nodosum.Kunz M, Beutel S, Brocker E.Department of Dermatology, University of Wurzburg, Germany.As

a neutrophilic vascular reaction of small vessels in the subcutaneous

tissue and a neutrophilic inflammatory infiltrate are common

histopathological features found in initial erythema nodosum (EN)

lesions, we asked the question whether activated polymorphonuclear

neutrophils (PMN) might play a role in the pathogenesis of EN. We

analysed the production of reactive oxygen intermediates (ROI) as a

marker for activated neutrophils in the peripheral blood of patients

suffering from EN (n = 10) and healthy volunteers (n = 10). FACS

analysis of dihydrorhodamine 123-stained PMN was used to detect ROI

production due to respiratory burst activity. Patients suffering from

EN had a fourfold higher percentage of preactivated ('primed')

ROI-producing PMN compared with healthy volunteers. Activation of PMN

with formylated methionyl-leucyl-phenylalanine and phorbol 12-myristate

13-acetate led to an increase of ROI production per cell but had no

influence on the percentage of activated cells. The percentage of

ROI-producing cells in patients with EN correlated with the clinical

severity. From these data, we conclude that ROI might play a role in

the pathogenesis of EN. ROI might exert their effects by oxidative

tissue damage and by promoting tissue inflammation.PMID: 10564331 [PubMed - indexed for MEDLINE]