Antimony chelation

[Guest guest]

Didn't I read on this list that SAMe should be used to chelate antimony?

My son is on DMSA/ALA therapy, 3 days on, 4 days off, every 3 hours. Can

SAMe be added in to this mix or should I postpone that for when he is

off the DMSA/ALA?

Thank you,

[Guest guest]

> Didn't I read on this list that SAMe should be used to chelate

antimony?

> My son is on DMSA/ALA therapy, 3 days on, 4 days off, every 3 hours.

Can

> SAMe be added in to this mix or should I postpone that for when he

is

> off the DMSA/ALA?

> Thank you,

>

,

While S-adenosylmethionine (sAMe) will probably bind antimony, both

DMSA and ALA have much greater affinity for antimony than sAMe. Since

you're already giving DMSA and ALA, you don't need to add anything

extra to remove antimony.

You may want to look into possible household sources of antimony, such

as carpet (antimony-based flame-retardants), tobacco smoke, and

possibly even antimony in your water supply. If the antimony is still

coming in, you will not see a decline in urine/blood/hair antimony

with treatment (makes sense).

Hope this helps,

Jim Laidler

[Guest guest]

> While S-adenosylmethionine (sAMe) will probably bind antimony, both

> DMSA and ALA have much greater affinity for antimony than sAMe.

Since

> you're already giving DMSA and ALA, you don't need to add anything

> extra to remove antimony.

This certainly is the opposite of what I've heard and seen. More

information, especially in the form of clinical experience or reports

would be well appreciated.

A

[Guest guest]

Antimony: I have also seen no literature reports of DMSA or ALA

chelating antimony, I have heard no clinical reports, I wouldn't expect

it from basic chemistry, and indeed I depend on Dr. Amy Holmes'

statements that DMSA does not work for antimony but SAMe does. Andy

Cutler

Antimony & DMSA

1: Res Commun Chem Pathol Pharmacol 1981 May;32(2):355-63

Structural requirements for chelate antidotal efficacy in acute

antimony(III) intoxication.

Basinger MA, MM

The LD50 for i.p. potassium antimonyl tartrate was determined to be 54.6

mg/kg in mice, with a 95% confidence range of 48.4 to 61.7 mg/kg. An

examination of the antidotal efficacy of a number of different

structural types of chelating agents showed that very few types were

able to act as antidotes when potassium antimonyl tartrate was

administered i.p. to mice at a level of 120 mg/kg. The most effective

antidotes, by a substantial margin, were the water soluble vicinal

dithiols: 2,3-dimercaptosuccinic acid and sodium

2.3-dimercaptopropane-1-sulfonate, with the first of these being

significantly better than the second. Appreciably less effective, but

still useful, was D-penicillamine. At this level of administration of

antimony(III), BAL is not an effective antidote. Among other chelating

agents which were also not effective at this level of antimony(III) are

tartaric acid, EDTA, cysteine, sodium diethyldithiocarbamate and

potassium dithiooxalate.

Bernie

[Guest guest]

SAMe chelates antimony. S

From: Coldren [mailto: corvids@...]To:

autism treatment@...: Mon, 2 Sep 2002 22:14:42 -0600Subject:

[ ] antimony as a chelatorIf TMG chelates antimony, is it unsafe

for my antimony toxic child to use it daily? We have been using it for my 21

month old, and have seen gains in speech. I was worried that, if it is

chelating her nonstop, she should get to have a rest, so I took her off it for a

week. She lost all her speech gains and remained nonverbal until several days

back on TMG. A week into TMG and she is still way behind where she had been.

Her Great Smokies' hair test showed her to be 93 times the upper reference range

for antimony, so she has a LOT to get rid of. Do I have to decide between her

ability to speak and her health? Is there something I am not considering? I

would LOVE to hear from anyone who has any relevant experience.Thanks,

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